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TAF5 chromatin modification protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 852497, updated on 13-Apr-2024

Summary

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Gene symbol
TAF5
Gene description
chromatin modification protein
Primary source
SGD:S000000402
Locus tag
YBR198C
See related
AllianceGenome:SGD:S000000402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TAF90
Summary
Enables chromatin binding activity; molecular adaptor activity; and ubiquitin binding activity. Involved in chromatin organization; histone acetylation; and transcription by RNA polymerase II. Part of SAGA complex; SLIK (SAGA-like) complex; and transcription factor TFIID complex. Orthologous to several human genes including TAF5 (TATA-box binding protein associated factor 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (616127..618523, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene putative mannosyltransferase Neighboring gene phosphatidylinositol-3-phosphate-binding protein BEM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a transcriptional activation domain in yeast repressor activator protein 1 (Rap1) using an altered DNA-binding specificity variant. Johnson AN, et al. J Biol Chem, 2017 Apr 7. PMID 28196871, Free PMC Article
  2. Mapping key functional sites within yeast TFIID. Leurent C, et al. EMBO J, 2004 Feb 25. PMID 14765106, Free PMC Article
  3. Yeast TAF(II)90 is required for cell-cycle progression through G2/M but not for general transcription activation. Apone LM, et al. Genes Dev, 1996 Sep 15. PMID 8824595
  4. Nucleotide sequence analysis of an 11.7 kb fragment of yeast chromosome II including BEM1, a new gene of the WD-40 repeat family and a new member of the KRE2/MNT1 family. Mallet L, et al. Yeast, 1994 Jun. PMID 7975899
  5. Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly. Romier C, et al. J Mol Biol, 2007 May 18. PMID 17397863

See all (143) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of primary metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SLIK (SAGA-like) complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chromatin modification protein
NP_009757.1
  • Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    616127..618523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178546.1 → NP_009757.1  TPA: chromatin modification protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009757.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQJ4, P38129
    UniProtKB/TrEMBL
    A0A6A5Q1B1, B3LMW2, B5VEE8, C7GKF9, D3UEU4, G2W9K1
    Conserved Domains (4) summary
    smart00667
    Location:55 → 88
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:458 → 722
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:470 → 523
    7WD40; WD40 repeat [structural motif]
    pfam04494
    Location:149 → 275
    TFIID_NTD2; WD40 associated region in TFIID subunit, NTD2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6T9I_D.1
6T9K_D.1
P38129.1

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