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Kpna2 karyopherin subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85245, updated on 11-Apr-2024

Summary

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Official Symbol
Kpna2provided by RGD
Official Full Name
karyopherin subunit alpha 2provided by RGD
Primary source
RGD:621419
See related
Ensembl:ENSRNOG00000015329 AllianceGenome:RGD:621419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
importin
Summary
Predicted to enable several functions, including histone deacetylase binding activity; nuclear import signal receptor activity; and nuclear localization sequence binding activity. Involved in regulation of transcription by glucose. Predicted to be located in cytoplasmic stress granule and cytosol. Predicted to be active in glutamatergic synapse and nucleoplasm. Predicted to be extrinsic component of postsynaptic specialization membrane. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1121.7), Thymus (RPKM 682.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (92433678..92445841, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91933951..91946115, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (95200029..95212111, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene survival of motor neuron-related-splicing factor 30-like Neighboring gene uncharacterized LOC108352149 Neighboring gene transfer RNA arginine (anticodon CCG) 2 Neighboring gene similar to human chromosome 17 open reading frame 58

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Upregulated Expression of Karyopherin α2 is Involved in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats. Xu Z, et al. Cell Mol Neurobiol, 2016 Jul. PMID 26340948
  2. A karyopherin alpha2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells. Cassany A, et al. Traffic, 2004 Jan. PMID 14675421
  3. Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation. Cai Y, et al. Dig Dis Sci, 2016 Mar. PMID 26526450
  4. The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function. Cattaruzzi G, et al. Nucleic Acids Res, 2007. PMID 17324944, Free PMC Article
  5. Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells. Guillemain G, et al. Biochem J, 2002 May 15. PMID 11988093, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Karyopherin alpha2 co-localized well with active caspase-3 in neurons, indicating its potential role in neuronal apoptosis
    Title: Upregulated Expression of Karyopherin α2 is Involved in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats.
  2. KPNA2-facilitated p65 nuclear translocation promotes NF-kappaB activation and inflammation in acute pancreatitis.
    Title: Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation.
  3. Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells
    Title: Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells.
  4. Data show that extracellular glucose regulates a nuclear transport pathway by increasing the nuclear efflux and shuttling of karyopherin alpha2 in cells in which glucose can stimulate the transcription of sugar-responsive genes.
    Title: A karyopherin alpha2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC108637

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NLS-bearing protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynapse to nucleus signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by glucose IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in host cell IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
importin subunit alpha-1
Names
importin subunit alpha-2
karyopherin (importin) alpha 2
karyopherin alpha 2
nuclear import protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270802.1 → NP_001257731.1  importin subunit alpha-1

    See identical proteins and their annotated locations for NP_001257731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC089787, FM083931, FM115539
    UniProtKB/TrEMBL
    A6HK66, F7F4Z2, Q6P6T9, Q9Z0N9
    Conserved Domains (3) summary
    COG5064
    Location:12 → 528
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:457 → 494
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:288 → 320
    ARM; armadillo repeat [structural motif]

  2. NM_053483.2 → NP_445935.2  importin subunit alpha-1

    See identical proteins and their annotated locations for NP_445935.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC089787, FM083931
    UniProtKB/TrEMBL
    A6HK66, F7F4Z2, Q6P6T9, Q9Z0N9
    Related
    ENSRNOP00000020795.3, ENSRNOT00000020795.7
    Conserved Domains (3) summary
    COG5064
    Location:12 → 528
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:457 → 494
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:288 → 320
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    92433678..92445841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270000.1 → XP_063126070.1  importin subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A6HK66, F7F4Z2, Q6P6T9
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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