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Plcb2 phospholipase C, beta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85240, updated on 13-Apr-2024

Summary

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Official Symbol
Plcb2provided by RGD
Official Full Name
phospholipase C, beta 2provided by RGD
Primary source
RGD:621004
See related
Ensembl:ENSRNOG00000058337 AllianceGenome:RGD:621004
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables G-protein beta/gamma-subunit complex binding activity; phosphatidylinositol phospholipase C activity; and phospholipid binding activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste and phospholipase C-activating G protein-coupled receptor signaling pathway. Located in Golgi apparatus; cytosol; and plasma membrane. Part of G-protein beta/gamma-subunit complex. Orthologous to human PLCB2 (phospholipase C beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 78.5), Lung (RPKM 46.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plcb2 in Genome Data Viewer
Location:
3q35
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126134925..126158303, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (105683676..105704384, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (110497760..110517563, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene ankyrin repeat domain 63 Neighboring gene uncharacterized LOC102548045 Neighboring gene InaF motif containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PKC-betaII is downregulated in the premature ovarian failure SD rat model.
    Title: PKC-βII is downregulated in the premature ovarian failure SD rat model.
  2. levels of Galphaq, Galpha11, PLCbeta-1, and PLC-beta2 proteins, as determined by western blotting, are significantly higher in vascular smooth muscle cells exposed to high glucose than in control cells.
    Title: Role of vasoactive peptides in high glucose-induced increased expression of Gαq/11 proteins and associated signaling in vascular smooth muscle cells.
  3. High glucose increases the expression of Gq/11alpha and PLC-beta proteins and associated signaling in vascular smooth muscle cells.
    Title: High glucose increases the expression of Gq/11alpha and PLC-beta proteins and associated signaling in vascular smooth muscle cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein beta/gamma-subunit complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phospholipase C activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of bitter taste IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of bitter taste ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of G-protein beta/gamma-subunit complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal dense core vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Names
PKC beta II
PLC-beta-2
phosphoinositide phospholipase C-beta-2
NP_445930.1
XP_038961925.1
XP_063140803.1
XP_063140804.1
XP_063140805.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053478.2 → NP_445930.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

    See identical proteins and their annotated locations for NP_445930.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    O89040
    UniProtKB/TrEMBL
    A0A0G2JZ43
    Related
    ENSRNOP00000070903.2, ENSRNOT00000078037.2
    Conserved Domains (8) summary
    cd00275
    Location:685 → 806
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 653
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    PLN02222
    Location:219 → 804
    PLN02222; phosphoinositide phospholipase C 2
    COG4942
    Location:827 → 1072
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd13361
    Location:17 → 144
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:976 → 1151
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:220 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl11531
    Location:1040 → 1119
    DUF904; Protein of unknown function (DUF904)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    126134925..126158303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284733.1 → XP_063140803.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

  2. XM_063284734.1 → XP_063140804.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

  3. XM_063284735.1 → XP_063140805.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

  4. XM_039105997.1 → XP_038961925.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

    Conserved Domains (3) summary
    cd16209
    Location:149 → 299
    EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
    pfam17787
    Location:12 → 141
    PH_14; PH domain
    cl14615
    Location:311 → 441
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RNA

  1. XR_001837051.2 RNA Sequence

  2. XR_010064706.1 RNA Sequence

  3. XR_005501996.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89040.1 GenPept UniProtKB/Swiss-Prot:O89040

Gene LinkOut

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Chemical Information
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Research Materials
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