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RFC5 replication factor C subunit 5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852383, updated on 13-Apr-2024

Summary

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Gene symbol
RFC5
Gene description
replication factor C subunit 5
Primary source
SGD:S000000291
Locus tag
YBR087W
See related
AllianceGenome:SGD:S000000291
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA clamp loader activity. Involved in leading strand elongation and sister chromatid cohesion. Part of chromosome. Orthologous to human RFC3 (replication factor C subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (423765..424829)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ist2p Neighboring gene proliferating cell nuclear antigen Neighboring gene uncharacterized protein Neighboring gene high-mobility group nucleosome-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of a 70 kb region on the right arm of yeast chromosome II. Mannhaupt G, et al. Yeast, 1994 Oct. PMID 7900426
  2. Allele-specific interactions between the yeast RFC1 and RFC5 genes suggest a basis for RFC subunit-subunit interactions. Beckwith W, et al. Mol Gen Genet, 2000 Nov. PMID 11129041
  3. Identification of the fifth subunit of Saccharomyces cerevisiae replication factor C. Gary SL, et al. Nucleic Acids Res, 1995 Dec 25. PMID 8559655, Free PMC Article
  4. Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast. Sugimoto K, et al. Proc Natl Acad Sci U S A, 1996 Jul 9. PMID 8692942, Free PMC Article
  5. The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1). Lengronne A, et al. Mol Cell, 2002 May. PMID 12049742

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel and critical role for the small RFC subunit Rfc5p promotes anti-establishment activities.
    Title: Rfc5p regulates alternate RFC complex functions in sister chromatid pairing reactions in budding yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA clamp unloading IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand elongation involved in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in leading strand elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ctf18 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor C complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DNA replication factor C complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of Elg1 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Elg1 RFC-like complex IEA
Inferred from Electronic Annotation
more info
  
part_of Elg1 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Rad17 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rad17 RFC-like complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rad17 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
replication factor C subunit 5
NP_009644.3
  • Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    423765..424829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178435.3 → NP_009644.3  TPA: replication factor C subunit 5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009644.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ88, P38251
    UniProtKB/TrEMBL
    A0A6A5Q146, A6ZL35, B3LN63, B5VE52, C7GJS2, D3UEI2, G2W995, N1P9F3
    Conserved Domains (2) summary
    COG0470
    Location:161 → 351
    HolB; DNA polymerase III, delta prime subunit [Replication, recombination and repair]
    PRK12402
    Location:3 → 243
    PRK12402; replication factor C small subunit 2; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38251.1

Gene LinkOut

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