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POL12 DNA-directed DNA polymerase alpha subunit POL12 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852245, updated on 13-Apr-2024

Summary

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Gene symbol
POL12
Gene description
DNA-directed DNA polymerase alpha subunit POL12
Primary source
SGD:S000000131
Locus tag
YBL035C
See related
AllianceGenome:SGD:S000000131
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA-directed DNA polymerase activity. Involved in DNA replication initiation and telomere capping. Located in nuclear envelope. Part of alpha DNA polymerase:primase complex. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (151493..153610, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Apl3p Neighboring gene uncharacterized protein Neighboring gene Stu1p Neighboring gene GTP cyclohydrolase II

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Foiani M, et al. Mol Cell Biol, 1994 Feb. PMID 8289832, Free PMC Article
  2. Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase alpha-primase B subunit. Foiani M, et al. Mol Cell Biol, 1995 Feb. PMID 7823954, Free PMC Article
  3. 3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases. Klinge S, et al. EMBO J, 2009 Jul 8. PMID 19494830, Free PMC Article
  4. Phosphorylation of the DNA polymerase alpha-primase B subunit is dependent on its association with the p180 polypeptide. Ferrari M, et al. J Biol Chem, 1996 Apr 12. PMID 8621497
  5. Purification and characterization of the 180- and 86-kilodalton subunits of the Saccharomyces cerevisiae DNA primase-DNA polymerase protein complex. The 180-kilodalton subunit has both DNA polymerase and 3'----5'-exonuclease activities. Brooke RG, et al. J Biol Chem, 1991 Feb 15. PMID 1704371

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere capping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere capping IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed DNA polymerase alpha subunit POL12
NP_009518.1
  • B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    151493..153610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178275.1 → NP_009518.1  TPA: DNA-directed DNA polymerase alpha subunit POL12 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009518.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPW4, P38121
    UniProtKB/TrEMBL
    A0A8H4F983, A6ZKR2, G2W8X3, N1PAX6
    Conserved Domains (1) summary
    COG5214
    Location:9 → 705
    POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38121.1

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