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RPN5 proteasome regulatory particle lid subunit RPN5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851408, updated on 5-May-2024

Summary

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Gene symbol
RPN5
Gene description
proteasome regulatory particle lid subunit RPN5
Primary source
SGD:S000002306
Locus tag
YDL147W
See related
AllianceGenome:SGD:S000002306
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NAS5
Summary
Involved in protein deneddylation. Located in proteasome storage granule. Part of COP9 signalosome and proteasome regulatory particle, lid subcomplex. Used to study cancer. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (190924..192261)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene autophagy protein ATG9 Neighboring gene snoRNA-binding rRNA-processing protein NOP14 Neighboring gene Ldb17p Neighboring gene coatomer subunit alpha

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NMR (1)H, (13)C, (15)N backbone and side chain resonance assignment of the N-terminal domain of yeast proteasome lid subunit Rpn5. Zhang W, et al. Biomol NMR Assign, 2019 Apr. PMID 30229448
  2. Solution structure of the N-terminal domain of proteasome lid subunit Rpn5. Zhang W, et al. Biochem Biophys Res Commun, 2018 Sep 26. PMID 30177392
  3. Solution structure of yeast Rpn9: insights into proteasome lid assembly. Hu Y, et al. J Biol Chem, 2015 Mar 13. PMID 25631053, Free PMC Article
  4. Small epitope-linker modules for PCR-based C-terminal tagging in Saccharomyces cerevisiae. Funakoshi M, et al. Yeast, 2009 Mar. PMID 19243080, Free PMC Article
  5. The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome. Isono E, et al. Mol Biol Cell, 2007 Feb. PMID 17135287, Free PMC Article

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of proteasome lid subunit Rpn5 solution structure
    Title: Solution structure of the N-terminal domain of proteasome lid subunit Rpn5.
  2. Data demonstrate that, in Saccharomyces cerevisiae, Rpn5 plays dual roles by stabilizing 26S proteasome and COP9 signalosome structures independently.
    Title: Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deneddylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, lid subcomplex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IEA
Inferred from Electronic Annotation
more info
  
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome regulatory particle lid subunit RPN5
NP_010134.1
  • Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    190924..192261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180207.1 → NP_010134.1  TPA: proteasome regulatory particle lid subunit RPN5 [Saccharomyces cerevisiae S288C]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRK1, Q12250
    UniProtKB/TrEMBL
    A0A6A5PYX7, A6ZXI0, B5VFC1, C7GKZ8, C8Z6F5, G2WC14, N1P956
    Conserved Domains (1) summary
    COG5071
    Location:5 → 445
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3JCK_B.1
3JCO_P.1
3JCP_P.1
5MPB_P.1
5MPC_P.1
5MPD_P.1
5MPE_P.1
5WVI_P.1
5WVK_P.1
6J2C_P.1
6J2N_P.1
6J2Q_P.1
6J2X_P.1
6J30_P.1
Q12250.3

Gene LinkOut

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