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TAL1 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851068, updated on 13-Apr-2024

Summary

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Gene symbol
TAL1
Gene description
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1
Primary source
SGD:S000004346
Locus tag
YLR354C
See related
AllianceGenome:SGD:S000004346
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables transaldolase activity. Involved in pentose-phosphate shunt. Located in nucleus. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder. Orthologous to human TALDO1 (transaldolase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (836350..837357, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Lug1p Neighboring gene Bud8p Neighboring gene ketol-acid reductoisomerase Neighboring gene Atg33p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heterologous expression of transaldolase gene Tal from Saccharomyces cerevisiae in Fusarium oxysporum for enhanced bioethanol production. Fan JX, et al. Appl Biochem Biotechnol, 2011 Aug. PMID 21394668
  2. Purification and properties of yeast transaldolase. HORECKER BL, et al. J Biol Chem, 1955 Feb. PMID 14353883
  3. Mechanism of action of transaldolase. I. Crystalization and properties of yeast enzyme. VENKATARAMAN R, et al. J Biol Chem, 1961 Jul. PMID 13780711
  4. Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase. Miosga T, et al. Yeast, 1993 Nov. PMID 8109173
  5. Molecular analysis of the structural gene for yeast transaldolase. Schaaff I, et al. Eur J Biochem, 1990 Mar 30. PMID 2185015

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transaldolase TAL1 paralogue NQM1 and the transcription factor VHR1 interact haploproficiently and affect yeast stationary phase survival.
    Title: A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance.
  2. characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
    Title: Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transaldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transaldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transaldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1
NP_013458.1
  • Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; TAL1 has a paralog, NQM1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    836350..837357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182243.1 → NP_013458.1  TPA: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013458.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYZ2, P15019
    UniProtKB/TrEMBL
    A0A6A5PS27, A7A1N2, B3RHM3, B5VNP4, C7GRX9, C8ZDW1, G2WJH2, N1NZP0
    Conserved Domains (1) summary
    TIGR00874
    Location:14 → 333
    talAB; transaldolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15019.4

Gene LinkOut

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