PRE4 proteasome core particle subunit beta 7 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Gene symbol: PRE4
Gene description: proteasome core particle subunit beta 7
Primary source: SGD:S000001946
Locus tag: YFR050C
See related: AllianceGenome:SGD:S000001946
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable threonine-type endopeptidase activity. Involved in proteasomal ubiquitin-independent protein catabolic process; proteasome assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, beta-subunit complex. Orthologous to human PSMB4 (proteasome 20S subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (249066..249866, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction with the Assembly Chaperone Ump1 Promotes Incorporation of the beta7 Subunit into Half-Proteasome Precursor Complexes Driving Their Dimerization.
Title: Interaction with the Assembly Chaperone Ump1 Promotes Incorporation of the β7 Subunit into Half-Proteasome Precursor Complexes Driving Their Dimerization.
Blm10 and the 19 S activator with Pre4 have a partially redundant function in stabilizing nascent 20 S proteasomes and in promoting their activation
Title: The C-terminal extension of the beta7 subunit and activator complexes stabilize nascent 20 S proteasomes and promote their maturation.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasomal ubiquitin-independent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, beta-subunit complex	IDA Inferred from Direct Assay more info	PubMed
located_in proteasome storage granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: proteasome core particle subunit beta 7

NP_116708.1

Beta 7 subunit of the 20S proteasome

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

249066..249866 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180015.1 → NP_116708.1 TPA: proteasome core particle subunit beta 7 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116708.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTT3, E9P8Z8, P30657

UniProtKB/TrEMBL

A0A8H8ULD3, A7A290, B3LUR1, B5VI75, C7GYF3, C8Z7Y5, G2WDJ1, N1P6J5

Conserved Domains (1) summary

cd03760
Location:40 → 236

proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
3JCO_2.1
3JCO_9.1
3JCP_2.1
3JCP_9.1
3WXR_2.1
3WXR_N.1
4X6Z_2.1
4X6Z_N.1
5MP9_7.1
5MP9_n.1
5MPA_7.1
5MPA_n.1
5MPB_7.1
5MPB_n.1
5MPC_7.1
5MPC_n.1
5NIF_2.1
5NIF_N.1
5WVI_7.1
5WVI_a.1
5WVK_7.1
5WVK_a.1
6EF3_7.1
6J2C_7.1
6J2C_a.1
6J2N_7.1
6J2N_a.1
6J2Q_7.1
6J2Q_a.1
6J2X_7.1
6J2X_a.1
6J30_7.1
6J30_a.1
7LS5_2.1
7LS5_N.1
P30657.1