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PTPN5 protein tyrosine phosphatase non-receptor type 5 [ Homo sapiens (human) ]

Gene ID: 84867, updated on 5-Mar-2024

Summary

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Official Symbol
PTPN5provided by HGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 5provided by HGNC
Primary source
HGNC:HGNC:9657
See related
Ensembl:ENSG00000110786 MIM:176879; AllianceGenome:HGNC:9657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STEP; STEP61; PTPSTEP
Summary
Enables phosphotyrosine residue binding activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be integral component of membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 11.0), testis (RPKM 0.9) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See PTPN5 in Genome Data Viewer
Location:
11p15.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18727928..18792721, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18825966..18890761, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18749475..18814268, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak1228 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18690003-18690504 Neighboring gene SRSF3 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18720033-18720534 Neighboring gene IGSF22 antisense RNA 1 Neighboring gene transmembrane protein 86A Neighboring gene immunoglobulin superfamily member 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:18770656-18771538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18783056-18783556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18783557-18784057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18792057-18792558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18792559-18793058 Neighboring gene Sharpr-MPRA regulatory region 5421 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:18819993-18821192 Neighboring gene MAS related GPR family member X8, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4514 Neighboring gene MAS related GPR family member X7, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism. Chatterjee M, et al. Behav Brain Res, 2020 Aug 5. PMID 32461127, Free PMC Article
  2. Striatal-enriched Tyrosine Protein Phosphatase (STEP) in the Mechanisms of Depressive Disorders. Kulikova E, et al. Curr Protein Pept Sci, 2017 Aug 30. PMID 28699511
  3. Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase. Chen YL, et al. Biochem Pharmacol, 2017 Aug 15. PMID 28528695
  4. Striatal-enriched phosphatase 61 inhibited the nociceptive plasticity in spinal cord dorsal horn of rats. Suo ZW, et al. Neuroscience, 2017 Jun 3. PMID 28389375
  5. Missense Variant in MAPK Inactivator PTPN5 Is Associated with Decreased Severity of Post-Burn Hypertrophic Scarring. Sood RF, et al. PLoS One, 2016. PMID 26872063, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology.
    Title: Tyrosine phosphatase STEP(61) in human dementia and in animal models with amyloid and tau pathology.
  2. Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism.
    Title: Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism.
  3. PTPN5 promotes follicle-stimulating hormone secretion through regulating intracellular calcium homeostasis.
    Title: PTPN5 promotes follicle-stimulating hormone secretion through regulating intracellular calcium homeostasis.
  4. that STEP61 is the molecular brake that is lost following KCC2-dependent disinhibition and that the decrease in STEP61 activity drives the potentiation of excitatory GluN2B NMDAR responses in rodent and human models of pathological pain
    Title: Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing.
  5. validated the functional importance of an identified interaction network by characterizing a distinct novel interaction between PTPN5 and Mob1a.
    Title: A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
  6. This current study demonstrated that spinal STEP61 regulated LTP of C fiber-evoked field potentials, one of the extensively studied cellular models of central sensitization.
    Title: Striatal-enriched phosphatase 61 inhibited the nociceptive plasticity in spinal cord dorsal horn of rats.
  7. a dual role for PSD-95 in stabilizing synaptic NMDARs by binding directly to GluN2B but also by promoting synaptic exclusion and degradation of the negative regulator STEP61.
    Title: PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61.
  8. STEP is involved in the mechanism of depressive disorders and it is a promising molecular target for atypical antidepressant drugs of new generation. (Review)
    Title: Striatal-enriched Tyrosine Protein Phosphatase (STEP) in the Mechanisms of Depressive Disorders.
  9. Data suggest that PP5/PTPN5 is overexpressed in liver samples from patients with hepatocellular carcinoma (HCC); overexpression of PP5/PTPN5 appears to correlate with tumor burden/stage. Inhibition of PP5/PTPN5 suppresses proliferation and promotes apoptosis of HCC cells; inhibition of PP5/PTPN5 involves activation of AMPK.
    Title: Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase.
  10. A rare missense variant in the PTPN5 gene (rs56234898; minor allele frequency 1.5%) was significantly associated with decreased severity of Post-Burn Hypertrophic Scarring(P = 1.3x10-6).
    Title: Missense Variant in MAPK Inactivator PTPN5 Is Associated with Decreased Severity of Post-Burn Hypertrophic Scarring.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14427

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphotyrosine residue binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 5
Names
neural-specific protein-tyrosine phosphatase
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
protein-tyrosine phosphatase striatum-enriched
striatal-enriched protein tyrosine phosphatase
striatum-enriched protein-tyrosine phosphatase
NP_001035059.1
NP_001265165.1
NP_001265167.1
NP_001265168.1
NP_008837.1
NP_116170.3
XP_016873923.1
XP_016873924.1
XP_016873925.1
XP_016873926.1
XP_016873927.1
XP_016873928.1
XP_054226212.1
XP_054226213.1
XP_054226214.1
XP_054226215.1
XP_054226216.1
XP_054226217.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039970.2 → NP_001035059.1  tyrosine-protein phosphatase non-receptor type 5 isoform b

    See identical proteins and their annotated locations for NP_001035059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AK127312, AL832541, BC046435
    Consensus CDS
    CCDS41626.1
    UniProtKB/TrEMBL
    B7Z2F8
    Conserved Domains (2) summary
    smart00194
    Location:267 → 520
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:293 → 520
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_001278236.1 → NP_001265165.1  tyrosine-protein phosphatase non-receptor type 5 isoform b

    See identical proteins and their annotated locations for NP_001265165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. Variants 3 and 4 encode the same isoform b.
    Source sequence(s)
    AK127312, AL832541, BC046435
    Consensus CDS
    CCDS41626.1
    UniProtKB/TrEMBL
    B7Z2F8
    Related
    ENSP00000379473.1, ENST00000396170.5
    Conserved Domains (2) summary
    smart00194
    Location:267 → 520
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:293 → 520
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  3. NM_001278238.2 → NP_001265167.1  tyrosine-protein phosphatase non-receptor type 5 isoform c

    See identical proteins and their annotated locations for NP_001265167.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon in the 5' region which causes translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-teminus, compared to isoform a.
    Source sequence(s)
    AK127312, AK295604, AL832541, BC046435
    Consensus CDS
    CCDS60746.1
    UniProtKB/TrEMBL
    B7Z2F8
    Related
    ENSP00000379471.1, ENST00000396168.1
    Conserved Domains (2) summary
    smart00194
    Location:275 → 528
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:301 → 528
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  4. NM_001278239.2 → NP_001265168.1  tyrosine-protein phosphatase non-receptor type 5 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an internal exon in the 5' region which causes translation initiation at a downstream start codon, and also has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (d) has a shorter N-terminus and lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AK294673, AL832541, BC046435, BC064807
    UniProtKB/TrEMBL
    B7Z2F8
    Conserved Domains (2) summary
    smart00194
    Location:243 → 496
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:269 → 496
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  5. NM_006906.2 → NP_008837.1  tyrosine-protein phosphatase non-receptor type 5 isoform a

    See identical proteins and their annotated locations for NP_008837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same longest isoform (a).
    Source sequence(s)
    AL832541, BC046435, BC064807
    Consensus CDS
    CCDS7845.1
    UniProtKB/Swiss-Prot
    B3KXG7, B7Z386, B7ZAF5, D3DQY7, P54829, Q6P1Z2, Q8N2A1, Q8NDP8
    UniProtKB/TrEMBL
    Q86TL6
    Related
    ENSP00000351342.2, ENST00000358540.7
    Conserved Domains (1) summary
    smart00194
    Location:299 → 552
    PTPc; Protein tyrosine phosphatase, catalytic domain

  6. NM_032781.4 → NP_116170.3  tyrosine-protein phosphatase non-receptor type 5 isoform a

    See identical proteins and their annotated locations for NP_116170.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform a.
    Source sequence(s)
    AK127312, BC046435, BC064807
    Consensus CDS
    CCDS7845.1
    UniProtKB/Swiss-Prot
    B3KXG7, B7Z386, B7ZAF5, D3DQY7, P54829, Q6P1Z2, Q8N2A1, Q8NDP8
    UniProtKB/TrEMBL
    Q86TL6
    Conserved Domains (1) summary
    smart00194
    Location:299 → 552
    PTPc; Protein tyrosine phosphatase, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    18727928..18792721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018439.2 → XP_016873928.1  tyrosine-protein phosphatase non-receptor type 5 isoform X5

  2. XM_017018436.2 → XP_016873925.1  tyrosine-protein phosphatase non-receptor type 5 isoform X2

  3. XM_017018435.3 → XP_016873924.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

  4. XM_017018437.2 → XP_016873926.1  tyrosine-protein phosphatase non-receptor type 5 isoform X3

  5. XM_017018434.3 → XP_016873923.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

  6. XM_017018438.3 → XP_016873927.1  tyrosine-protein phosphatase non-receptor type 5 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    18825966..18890761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370242.1 → XP_054226217.1  tyrosine-protein phosphatase non-receptor type 5 isoform X5

  2. XM_054370239.1 → XP_054226214.1  tyrosine-protein phosphatase non-receptor type 5 isoform X2

  3. XM_054370238.1 → XP_054226213.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

  4. XM_054370240.1 → XP_054226215.1  tyrosine-protein phosphatase non-receptor type 5 isoform X3

  5. XM_054370237.1 → XP_054226212.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

  6. XM_054370241.1 → XP_054226216.1  tyrosine-protein phosphatase non-receptor type 5 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54829.4 GenPept UniProtKB/Swiss-Prot:P54829

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