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IL17RC interleukin 17 receptor C [ Homo sapiens (human) ]

Gene ID: 84818, updated on 3-Apr-2024

Summary

Official Symbol
IL17RCprovided by HGNC
Official Full Name
interleukin 17 receptor Cprovided by HGNC
Primary source
HGNC:HGNC:18358
See related
Ensembl:ENSG00000163702 MIM:610925; AllianceGenome:HGNC:18358
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CANDF9; IL17RL; IL17-RL
Summary
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in prostate (RPKM 15.4), skin (RPKM 9.6) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See IL17RC in Genome Data Viewer
Location:
3p25.3; 3p25.3-p24.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (9917098..9933621)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (9909121..9925611)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9958782..9975305)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene jagunal homolog 1 Neighboring gene Sharpr-MPRA regulatory region 14744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9944736-9945405 Neighboring gene interleukin 17 receptor E Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14049 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9958035-9958574 Neighboring gene RNA, U6 small nuclear 882, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9970047-9970546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19413 Neighboring gene cysteine rich with EGF like domains 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9980935-9981732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9987356-9988018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9988681-9989342 Neighboring gene PRRT3 antisense RNA 1 Neighboring gene 3p25 PRRT3 Alu-mediated recombination region Neighboring gene proline rich transmembrane protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14052

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ95963, FLJ96005, MGC10763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables coreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables interleukin-17 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-17 receptor C
Names
IL-17 receptor C
IL-17RL
IL17F receptor
IL17Rhom
interleukin-17 receptor homolog
interleukin-17 receptor-like protein
zcytoR14

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029376.2 RefSeqGene

    Range
    5001..21524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1311

mRNA and Protein(s)

  1. NM_001203263.2NP_001190192.2  interleukin-17 receptor C isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the penultimate coding exon compared to variant 1, however, maintains the reading frame. This results in a shorter isoform (4) missing a protein segment in the C-terminal region compared to isoform 1.
    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS56240.1
    UniProtKB/TrEMBL
    A0A8Q3SJ19
    Related
    ENSP00000396064.1, ENST00000413608.2
    Conserved Domains (2) summary
    pfam08357
    Location:506653
    SEFIR; SEFIR domain
    pfam15037
    Location:71459
    IL17_R_N; Interleukin-17 receptor extracellular region
  2. NM_001203264.2NP_001190193.2  interleukin-17 receptor C isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks 2 in-frame coding exons (exon 12 and penultimate exon) compared to variant 1, resulting in a shorter isoform (5, also known as IL-17RCdelta12) missing 2 internal protein segments compared to isoform 1. It has been reported that isoforms lacking exon 12 lose the ability to bind cytokines, IL-17A and IL-17F (PMID:17911633).
    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS74898.1
    UniProtKB/TrEMBL
    A0A8Q3SIU5
    Related
    ENSP00000395315.3, ENST00000416074.6
    Conserved Domains (3) summary
    pfam08357
    Location:489636
    SEFIR; SEFIR domain
    pfam15037
    Location:71442
    IL17_R_N; Interleukin-17 receptor extracellular region
    pfam17243
    Location:632668
    POTRA_TamA_1; POTRA domain TamA domain 1
  3. NM_001203265.2NP_001190194.2  interleukin-17 receptor C isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks 2 in-frame coding exons (exons 7 and 12) compared to variant 1, resulting in a shorter isoform (6, also known as IL-17RCdelta7,12) missing 2 internal protein segments compared to isoform 1. It has been reported that isoforms lacking exon 12 lose the ability to bind cytokines, IL-17A and IL-17F (PMID:17911633).
    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS56241.1
    UniProtKB/TrEMBL
    A0A8Q3SIU5
    Related
    ENSP00000407894.1, ENST00000455057.5
    Conserved Domains (2) summary
    pfam08357
    Location:487634
    SEFIR; SEFIR domain
    pfam15037
    Location:71427
    IL17_R_N; Interleukin-17 receptor extracellular region
  4. NM_001367278.1NP_001354207.1  interleukin-17 receptor C isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS93201.1
    UniProtKB/TrEMBL
    A0A8Q3SIV5, A0A8Q3SJJ9
    Related
    ENSP00000512902.1, ENST00000696824.1
    Conserved Domains (2) summary
    pfam08357
    Location:493640
    SEFIR; SEFIR domain
    pfam15037
    Location:71446
    IL17_R_N; Interleukin-17 receptor extracellular region
  5. NM_001367279.1NP_001354208.1  interleukin-17 receptor C isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC018809
    UniProtKB/TrEMBL
    A0A8Q3WM30
    Conserved Domains (2) summary
    pfam08357
    Location:466613
    SEFIR; SEFIR domain
    pfam15037
    Location:71419
    IL17_R_N; Interleukin-17 receptor extracellular region
  6. NM_001367280.1NP_001354209.1  interleukin-17 receptor C isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS93202.1
    UniProtKB/TrEMBL
    A0A8Q3SJ19
    Related
    ENSP00000512897.1, ENST00000696816.1
    Conserved Domains (2) summary
    pfam08357
    Location:491638
    SEFIR; SEFIR domain
    pfam15037
    Location:71444
    IL17_R_N; Interleukin-17 receptor extracellular region
  7. NM_001410711.1NP_001397640.1  interleukin-17 receptor C isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS93203.1
    UniProtKB/TrEMBL
    A0A8Q3SJ01
    Related
    ENSP00000512904.1, ENST00000696826.1
  8. NM_032732.6NP_116121.3  interleukin-17 receptor C isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon (exon 7) compared to variant 1, resulting in a shorter isoform (3, also known as IL-17RCdelta7) missing an internal protein segment compared to isoform 1. It has been reported that isoform lacking exon 7 retains the ability to bind cytokines, IL-17A and IL-17F (PMID:17911633).
    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS2591.2
    UniProtKB/TrEMBL
    A0A8Q3SJ19
    Related
    ENSP00000373323.4, ENST00000383812.9
    Conserved Domains (2) summary
    pfam08357
    Location:504651
    SEFIR; SEFIR domain
    pfam15037
    Location:71444
    IL17_R_N; Interleukin-17 receptor extracellular region
  9. NM_153460.4NP_703190.2  interleukin-17 receptor C isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript containing all the coding exons, and encodes isoform 1 (also known as IL-17RCFL).
    Source sequence(s)
    AC018809, AF458065, AK096824, AK225650, AY358840, DC381087
    Consensus CDS
    CCDS46746.1
    UniProtKB/TrEMBL
    A0A8Q3SJ19
    Related
    ENSP00000384969.3, ENST00000403601.8
    Conserved Domains (2) summary
    pfam08357
    Location:519666
    SEFIR; SEFIR domain
    pfam15037
    Location:71459
    IL17_R_N; Interleukin-17 receptor extracellular region
  10. NM_153461.4NP_703191.2  interleukin-17 receptor C isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal coding exon compared to variant 1, resulting in a longer isoform (2) containing an additional protein segment compared to isoform 1.
    Source sequence(s)
    AC018809
    Consensus CDS
    CCDS2590.1
    UniProtKB/Swiss-Prot
    A8BWC1, A8BWC9, A8BWD5, E9PHG1, E9PHJ6, Q6UVY3, Q6UWD4, Q8NAC3, Q8NFS1, Q9BR97
    UniProtKB/TrEMBL
    A0A8Q3SJ19
    Related
    ENSP00000295981.3, ENST00000295981.7
    Conserved Domains (2) summary
    pfam08357
    Location:590737
    SEFIR; SEFIR domain
    pfam15037
    Location:142530
    IL17_R_N; Interleukin-17 receptor extracellular region

RNA

  1. NR_037807.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks exon 7 and is alternatively spliced in the mid-coding region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC018809
    Related
    ENST00000466046.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    9917098..9933621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007326.1XP_016862815.1  interleukin-17 receptor C isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SJ19
  2. XM_017007327.2XP_016862816.1  interleukin-17 receptor C isoform X2

    UniProtKB/TrEMBL
    A0A8Q3SJ19
  3. XM_017007329.2XP_016862818.1  interleukin-17 receptor C isoform X4

    UniProtKB/TrEMBL
    A0A8Q3SJ19
  4. XM_017007333.1XP_016862822.1  interleukin-17 receptor C isoform X8

    UniProtKB/TrEMBL
    A0A8Q3SIU5
  5. XM_017007336.2XP_016862825.1  interleukin-17 receptor C isoform X12

    UniProtKB/TrEMBL
    A0A8Q3SIU5
  6. XM_017007328.1XP_016862817.1  interleukin-17 receptor C isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SJJ9
  7. XM_017007330.1XP_016862819.1  interleukin-17 receptor C isoform X5

    UniProtKB/TrEMBL
    A0A8Q3SJJ9
  8. XM_017007331.1XP_016862820.1  interleukin-17 receptor C isoform X6

    UniProtKB/TrEMBL
    A0A8Q3SJ19
  9. XM_017007332.1XP_016862821.1  interleukin-17 receptor C isoform X7

    UniProtKB/TrEMBL
    A0A8Q3SJ19
  10. XM_024453793.2XP_024309561.1  interleukin-17 receptor C isoform X10

    UniProtKB/TrEMBL
    A0A8Q3SJ19
    Conserved Domains (2) summary
    pfam08357
    Location:562709
    SEFIR; SEFIR domain
    pfam15037
    Location:142515
    IL17_R_N; Interleukin-17 receptor extracellular region
  11. XM_047449066.1XP_047305022.1  interleukin-17 receptor C isoform X13

  12. XM_017007339.2XP_016862828.1  interleukin-17 receptor C isoform X16

    UniProtKB/TrEMBL
    A0A8Q3SIU5
  13. XM_017007335.1XP_016862824.1  interleukin-17 receptor C isoform X11

    UniProtKB/TrEMBL
    A0A8Q3SJ19
  14. XM_017007338.2XP_016862827.1  interleukin-17 receptor C isoform X15

    UniProtKB/TrEMBL
    A0A8Q3SJ19
  15. XM_024453794.1XP_024309562.1  interleukin-17 receptor C isoform X17

    UniProtKB/TrEMBL
    A0A8Q3SIU5
    Conserved Domains (2) summary
    pfam08357
    Location:545692
    SEFIR; SEFIR domain
    pfam15037
    Location:142485
    IL17_R_N; Interleukin-17 receptor extracellular region
  16. XM_017007334.1XP_016862823.1  interleukin-17 receptor C isoform X9

    UniProtKB/TrEMBL
    A0A8Q3WM30
  17. XM_017007337.1XP_016862826.1  interleukin-17 receptor C isoform X14

    UniProtKB/TrEMBL
    A0A8Q3WM30
  18. XM_047449067.1XP_047305023.1  interleukin-17 receptor C isoform X19

  19. XM_017007340.2XP_016862829.1  interleukin-17 receptor C isoform X18

    UniProtKB/TrEMBL
    A0A8Q3SJ19
  20. XM_047449068.1XP_047305024.1  interleukin-17 receptor C isoform X20

  21. XM_047449070.1XP_047305026.1  interleukin-17 receptor C isoform X23

  22. XM_047449069.1XP_047305025.1  interleukin-17 receptor C isoform X21

  23. XM_017007341.2XP_016862830.1  interleukin-17 receptor C isoform X22

    UniProtKB/TrEMBL
    A0A8Q3SJ19
  24. XM_047449071.1XP_047305027.1  interleukin-17 receptor C isoform X26

  25. XM_017007345.2XP_016862834.1  interleukin-17 receptor C isoform X27

    UniProtKB/TrEMBL
    A0A8Q3SJ19
  26. XM_047449072.1XP_047305028.1  interleukin-17 receptor C isoform X28

  27. XM_047449075.1XP_047305031.1  interleukin-17 receptor C isoform X32

  28. XM_017007348.2XP_016862837.1  interleukin-17 receptor C isoform X33

    UniProtKB/TrEMBL
    A0A8Q3SIU5
  29. XM_017007342.1XP_016862831.1  interleukin-17 receptor C isoform X24

    UniProtKB/TrEMBL
    A0A8Q3WM30
  30. XM_017007343.1XP_016862832.1  interleukin-17 receptor C isoform X25

    UniProtKB/TrEMBL
    A0A8Q3WM30
  31. XM_047449073.1XP_047305029.1  interleukin-17 receptor C isoform X29

  32. XM_017007347.1XP_016862836.1  interleukin-17 receptor C isoform X30

    UniProtKB/TrEMBL
    A0A8Q3WM30
  33. XM_047449077.1XP_047305033.1  interleukin-17 receptor C isoform X34

    UniProtKB/TrEMBL
    C9JSZ3
    Related
    ENSP00000414609.2, ENST00000438091.6
  34. XM_047449074.1XP_047305030.1  interleukin-17 receptor C isoform X31

  35. XM_047449079.1XP_047305035.1  interleukin-17 receptor C isoform X36

  36. XM_047449080.1XP_047305036.1  interleukin-17 receptor C isoform X37

  37. XM_047449078.1XP_047305034.1  interleukin-17 receptor C isoform X35

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    9909121..9925611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348098.1XP_054204073.1  interleukin-17 receptor C isoform X1

  2. XM_054348099.1XP_054204074.1  interleukin-17 receptor C isoform X2

  3. XM_054348101.1XP_054204076.1  interleukin-17 receptor C isoform X4

  4. XM_054348105.1XP_054204080.1  interleukin-17 receptor C isoform X8

  5. XM_054348109.1XP_054204084.1  interleukin-17 receptor C isoform X12

  6. XM_054348100.1XP_054204075.1  interleukin-17 receptor C isoform X3

  7. XM_054348102.1XP_054204077.1  interleukin-17 receptor C isoform X5

  8. XM_054348103.1XP_054204078.1  interleukin-17 receptor C isoform X6

  9. XM_054348104.1XP_054204079.1  interleukin-17 receptor C isoform X7

  10. XM_054348107.1XP_054204082.1  interleukin-17 receptor C isoform X10

  11. XM_054348110.1XP_054204085.1  interleukin-17 receptor C isoform X13

  12. XM_054348113.1XP_054204088.1  interleukin-17 receptor C isoform X16

  13. XM_054348108.1XP_054204083.1  interleukin-17 receptor C isoform X11

  14. XM_054348112.1XP_054204087.1  interleukin-17 receptor C isoform X15

  15. XM_054348114.1XP_054204089.1  interleukin-17 receptor C isoform X17

  16. XM_054348106.1XP_054204081.1  interleukin-17 receptor C isoform X9

  17. XM_054348111.1XP_054204086.1  interleukin-17 receptor C isoform X14

  18. XM_054348116.1XP_054204091.1  interleukin-17 receptor C isoform X19

  19. XM_054348115.1XP_054204090.1  interleukin-17 receptor C isoform X18

  20. XM_054348117.1XP_054204092.1  interleukin-17 receptor C isoform X20

  21. XM_054348120.1XP_054204095.1  interleukin-17 receptor C isoform X23

  22. XM_054348118.1XP_054204093.1  interleukin-17 receptor C isoform X21

  23. XM_054348119.1XP_054204094.1  interleukin-17 receptor C isoform X22

  24. XM_054348123.1XP_054204098.1  interleukin-17 receptor C isoform X26

  25. XM_054348124.1XP_054204099.1  interleukin-17 receptor C isoform X27

  26. XM_054348125.1XP_054204100.1  interleukin-17 receptor C isoform X28

  27. XM_054348129.1XP_054204104.1  interleukin-17 receptor C isoform X32

  28. XM_054348130.1XP_054204105.1  interleukin-17 receptor C isoform X33

  29. XM_054348121.1XP_054204096.1  interleukin-17 receptor C isoform X24

  30. XM_054348122.1XP_054204097.1  interleukin-17 receptor C isoform X25

  31. XM_054348126.1XP_054204101.1  interleukin-17 receptor C isoform X29

  32. XM_054348127.1XP_054204102.1  interleukin-17 receptor C isoform X30

  33. XM_054348131.1XP_054204106.1  interleukin-17 receptor C isoform X34

  34. XM_054348128.1XP_054204103.1  interleukin-17 receptor C isoform X31

  35. XM_054348133.1XP_054204108.1  interleukin-17 receptor C isoform X36

  36. XM_054348134.1XP_054204109.1  interleukin-17 receptor C isoform X37

  37. XM_054348132.1XP_054204107.1  interleukin-17 receptor C isoform X35

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153462.1: Suppressed sequence

    Description
    NM_153462.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_153463.1: Suppressed sequence

    Description
    NM_153463.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.