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COX4I2 cytochrome c oxidase subunit 4I2 [ Homo sapiens (human) ]

Gene ID: 84701, updated on 17-Mar-2024

Summary

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Official Symbol
COX4I2provided by HGNC
Official Full Name
cytochrome c oxidase subunit 4I2provided by HGNC
Primary source
HGNC:HGNC:16232
See related
Ensembl:ENSG00000131055 MIM:607976; AllianceGenome:HGNC:16232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COX4; COX4B; COX4-2; COX4L2; COXIV-2; dJ857M17.2
Summary
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 32.5), lung (RPKM 10.0) and 6 other tissues See more
Orthologs
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Genomic context

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Location:
20q11.21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (31637912..31645006)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33362179..33369276)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30225715..30232809)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30192859-30193529 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30193530-30194199 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30194246-30194824 Neighboring gene Sharpr-MPRA regulatory region 11771 Neighboring gene CRISPRi-validated cis-regulatory element chr20.845 Neighboring gene CRISPRi-validated cis-regulatory element chr20.846 Neighboring gene microRNA 3193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30206543-30207044 Neighboring gene inhibitor of DNA binding 1 Neighboring gene MPRA-validated peak4184 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30221506-30222006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30222007-30222507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12759 Neighboring gene MPRA-validated peak4185 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30249151-30249878 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:30251554-30252384 Neighboring gene uncharacterized LOC124904883 Neighboring gene VISTA enhancer hs2050 Neighboring gene BCL2 like 1 Neighboring gene BCL2L1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30285857-30286804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17693 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30300575-30301102 Neighboring gene Sharpr-MPRA regulatory region 251

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC. Li JP, et al. Cell Mol Biol Lett, 2022 Sep 5. PMID 36064310, Free PMC Article
  2. Transcription of mammalian cytochrome c oxidase subunit IV-2 is controlled by a novel conserved oxygen responsive element. Hüttemann M, et al. FEBS J, 2007 Nov. PMID 17937768
  3. Effects of hemin on apoptosis, suppression of cytochrome c oxidase gene expression, and bone-marrow toxicity induced by doxorubicin (adriamycin). Papadopoulou LC, et al. Biochem Pharmacol, 1996 Sep 13. PMID 8765469
  4. Isolation, subunit composition, and site of synthesis of human cytochrome c oxidase. Hare JF, et al. Biochemistry, 1980 May 13. PMID 6246917
  5. The interconversion between monomeric and dimeric bovine heart cytochrome c oxidase. Bolli R, et al. Biochimie, 1985 Jan. PMID 2986725

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HIF1A transcriptional regulation of COX4I2 impacts angiogenesis in pheochromocytoma.
    Title: HIF1A transcriptional regulation of COX4I2 impacts angiogenesis in pheochromocytoma.
  2. Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC.
    Title: Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC.
  3. Upregulation of COX4-2 via HIF-1alpha in Mitochondrial COX4-1 Deficiency.
    Title: Upregulation of COX4-2 via HIF-1α in Mitochondrial COX4-1 Deficiency.
  4. COX4I2 and PLAT were highly correlated with blood supply in adrenal pheochromocytoma which contribute to angiogenesis in adrenal pheochromocytoma, which could be used as biomarkers to better indicate tumor angiogenesis
    Title: From clinic to mechanism: Proteomics-based assessment of angiogenesis in adrenal pheochromocytoma.
  5. Identification of three transcription factors that bind a conserved responsive element of the COX4I2 gene, namely recombination signal sequence-binding protein Jkappa (RBPJ), coiled-coil-helix-coiled-coil-helix domain 2 (CHCHD2) and CXXC finger protein 5 (CXXC5).
    Title: Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  7. Mutation analysis of COX4I2 is warranted in patients with malabsorption due to exocrine pancreatic insufficiency and in patients with dyserythropoeitic anemia.
    Title: Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene.
  8. COX4I2 is regulated by a novel oxygen sensitive promoter element (5'-GGACGTTCCCACG-3') conserved in mammals. Gene activity is maximal at 4% oxygen. Lung cytochrome c oxidase (COX) is 2.5 fold more active compared to liver COX, which lacks COX4I2.
    Title: Transcription of mammalian cytochrome c oxidase subunit IV-2 is controlled by a novel conserved oxygen responsive element.
  9. COX4I2 is expressed in the highly oxygenated lung tissue. It is found in all cell types of the lung.
    Title: Mammalian subunit IV isoforms of cytochrome c oxidase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Pancreatic insufficiency-anemia-hyperostosis syndrome
MedGen: C2675184 OMIM: 612714 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytochrome-c oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in generation of precursor metabolites and energy NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex IV IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Names
COX IV-2
cytochrome c oxidase subunit IV-like 2
NP_115998.2
XP_005260636.1
XP_005260637.1
XP_005260638.1
XP_054180123.1
XP_054180124.1
XP_054180125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012180.1 RefSeqGene

    Range
    5025..12119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032609.3 → NP_115998.2  cytochrome c oxidase subunit 4 isoform 2, mitochondrial

    See identical proteins and their annotated locations for NP_115998.2

    Status: REVIEWED

    Source sequence(s)
    AL117381
    Consensus CDS
    CCDS13187.1
    UniProtKB/Swiss-Prot
    Q6GTF4, Q96KJ9, Q9H0Z4
    UniProtKB/TrEMBL
    H6SG14
    Related
    ENSP00000365243.3, ENST00000376075.4
    Conserved Domains (1) summary
    cd00922
    Location:39 → 164
    Cyt_c_Oxidase_IV; Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    31637912..31645006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260581.4 → XP_005260638.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl02792
    Location:40 → 126
    Cyt_c_Oxidase_IV; Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. XM_005260580.5 → XP_005260637.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl02792
    Location:32 → 125
    Cyt_c_Oxidase_IV; Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  3. XM_005260579.5 → XP_005260636.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam02936
    Location:45 → 175
    COX4; Cytochrome c oxidase subunit IV

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    33362179..33369276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324150.1 → XP_054180125.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X3

  2. XM_054324149.1 → XP_054180124.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

  3. XM_054324148.1 → XP_054180123.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96KJ9.2 GenPept UniProtKB/Swiss-Prot:Q96KJ9

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