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Socs2 suppressor of cytokine signaling 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84607, updated on 13-Apr-2024

Summary

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Official Symbol
Socs2provided by RGD
Official Full Name
suppressor of cytokine signaling 2provided by RGD
Primary source
RGD:69273
See related
Ensembl:ENSRNOG00000008965 AllianceGenome:RGD:69273
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cish2; Socs-2
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity; growth hormone receptor binding activity; and insulin-like growth factor receptor binding activity. Involved in aging and response to peptide hormone. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 354.2), Spleen (RPKM 119.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (31890564..31932092, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (30006360..30045161, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (36495496..36500878, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene death domain-containing protein CRADD-like Neighboring gene DnaJ heat shock protein family (Hsp40) member C30, pseudogene 1 Neighboring gene uncharacterized LOC134479866 Neighboring gene uncharacterized LOC134479868 Neighboring gene proteasome subunit alpha type-4-like Neighboring gene mitochondrial ribosomal protein L42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SOCS2 exacerbates myocardial injury induced by ischemia/reperfusion in diabetic mice and H9c2 cells through inhibiting the JAK-STAT-IGF-1 pathway. Sheng M, et al. Life Sci, 2017 Nov 1. PMID 28867579
  2. Enhanced expression of SOCS-2 in the rat hippocampus after transient forebrain ischemia. Choi JS, et al. J Neurotrauma, 2009 Nov. PMID 19469688
  3. Evolution of the androgen receptor pathway during progression of prostate cancer. Hendriksen PJ, et al. Cancer Res, 2006 May 15. PMID 16707422
  4. Methylated DNA collected by tampons--a new tool to detect endometrial cancer. Fiegl H, et al. Cancer Epidemiol Biomarkers Prev, 2004 May. PMID 15159323
  5. SOCS2 induces neurite outgrowth by regulation of epidermal growth factor receptor activation. Goldshmit Y, et al. J Biol Chem, 2004 Apr 16. PMID 14764607

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. research suggests that overexpressed SOCS2 might exacerbate myocardial ischemia/reperfusion injury in type 2 diabetes mellitus by inhibiting the expression of Insulin-like Growth Factor-1 via the Janus kinase-signal transducer and activator of transcription signaling pathway.
    Title: SOCS2 exacerbates myocardial injury induced by ischemia/reperfusion in diabetic mice and H9c2 cells through inhibiting the JAK-STAT-IGF-1 pathway.
  2. SOCS2 is a negative feed back regulator of growth hormone receptor. SOCS2 deletion in mice causes gigantism.
    Title: SOCS2 negatively regulates growth hormone action in vitro and in vivo.
  3. SOCS-2 may be involved in glial reactions, and possibly adult hippocampal neurogenesis during ischemic insults.
    Title: Enhanced expression of SOCS-2 in the rat hippocampus after transient forebrain ischemia.
  4. insulin can inhibit the mitogenic action of IGF-1 in mesangial cells by regulating STAT5/SOCS2 expression.
    Title: Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.
  5. Data show that althhough we observed OVX-related increases in SOCS2 and SOCS3 mRNA, SOCS2 and SOCS3 protein did not differ among groups.
    Title: Effect of ovariectomy on cardiac gene expression: inflammation and changes in SOCS gene expression.
  6. SOC-2 induced by GH may play an important role in suppressing collagen accumulation and mesenchymal cell proliferation induced by GH or GH-induced IGF-I
    Title: Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells.
  7. suppressor of cytokine signaling 2 is a direct signal transducer and activator of transcription 5b target in liver
    Title: In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver.
  8. SOCS-2 displays a relatively higher level of basal expression in the hippocampus than SOCS-1, and a mild, transient downregulation by 24 hr, supporting the hypothesis that seizure-induced gp130 cytokines play a direct neuromodulatory role in the brain.
    Title: Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines.
  9. Up-regulation of SOCS2 in neuronal progenitor cells derived from the adult SVZ may regulate erythropoietin enhanced neuronal differentiation.
    Title: Erythropoietin up-regulates SOCS2 in neuronal progenitor cells derived from SVZ of adult rat.
  10. SOCS-2 is a growth hormone-inducible, novel inhibitor of intestinal epithelial cell proliferation and intestinal growth.
    Title: Suppressor of cytokine signaling-2: a growth hormone-inducible inhibitor of intestinal epithelial cell proliferation.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth hormone receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables growth hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin-like growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in growth hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in lactation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lactation ISO
Inferred from Sequence Orthology
more info
  
involved_in mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
  
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
suppressor of cytokine signaling 2
Names
cytokine inducible SH2-containing protein 2
cytokine-inducible SH2 protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_058208.2 → NP_478115.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_478115.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    O88582
    UniProtKB/TrEMBL
    A6IG31, A6IG33
    Conserved Domains (2) summary
    cd10383
    Location:40 → 142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158 → 198
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    31890564..31932092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079991.2 → XP_038935919.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    A6IG31
    Conserved Domains (2) summary
    cd10383
    Location:40 → 142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158 → 197
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  2. XM_039079992.2 → XP_038935920.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    A6IG31
    Conserved Domains (2) summary
    cd10383
    Location:40 → 142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158 → 197
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  3. XM_039079993.2 → XP_038935921.1  suppressor of cytokine signaling 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AD64, A6IG31
    Related
    ENSRNOP00000089730.1
    Conserved Domains (2) summary
    cd10383
    Location:40 → 142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158 → 197
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  4. XM_017595137.3 → XP_017450626.1  suppressor of cytokine signaling 2 isoform X2

    UniProtKB/Swiss-Prot
    O88582
    UniProtKB/TrEMBL
    A6IG31, A6IG33
    Conserved Domains (2) summary
    cd10383
    Location:40 → 142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158 → 198
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  5. XM_063264346.1 → XP_063120416.1  suppressor of cytokine signaling 2 isoform X2

    UniProtKB/Swiss-Prot
    O88582
    UniProtKB/TrEMBL
    A6IG33

  6. XM_063264345.1 → XP_063120415.1  suppressor of cytokine signaling 2 isoform X2

    UniProtKB/Swiss-Prot
    O88582
    UniProtKB/TrEMBL
    A6IG33

  7. XM_063264347.1 → XP_063120417.1  suppressor of cytokine signaling 2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88582.1 GenPept UniProtKB/Swiss-Prot:O88582

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