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Fads1 fatty acid desaturase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84575, updated on 2-May-2024

Summary

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Official Symbol
Fads1provided by RGD
Official Full Name
fatty acid desaturase 1provided by RGD
Primary source
RGD:621678
See related
Ensembl:ENSRNOG00000020480 AllianceGenome:RGD:621678
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables acyl-CoA delta5-desaturase activity. Involved in several processes, including response to isolation stress; response to vitamin A; and unsaturated fatty acid metabolic process. Located in nucleus. Biomarker of hypertension and obesity. Orthologous to human FADS1 (fatty acid desaturase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1280.8), Adrenal (RPKM 1205.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216252605..216267618)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206827724..206842734)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226234034..226249118)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene fatty acid desaturase 2 Neighboring gene uncharacterized LOC134483970 Neighboring gene S-formylglutathione hydrolase-like Neighboring gene transmembrane protein 258 Neighboring gene flap structure-specific endonuclease 1 Neighboring gene myelin regulatory factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Delta5 and Delta6 desaturases, SREBP-1, PPARalpha, and PGC-1. Rodriguez-Cruz M, et al. J Lipid Res, 2006 Mar. PMID 16333142
  2. Effects of fenofibrate and insulin on the biosynthesis of unsaturated fatty acids in streptozotocin diabetic rats. Montanaro MA, et al. Prostaglandins Leukot Essent Fatty Acids, 2005 Nov. PMID 16099631
  3. Desaturase activities in rat model of insulin resistance induced by a sucrose-rich diet. Brenner RR, et al. Lipids, 2003 Jul. PMID 14506836
  4. Desaturase activities are depleted before and after weaning in liver microsomes of spontaneously hypertensive rats. Savelli JL, et al. Prostaglandins Leukot Essent Fatty Acids, 2002 May-Jun. PMID 12144877
  5. Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity. Nishida S, et al. J Pineal Res, 2002 Jan. PMID 11841597

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that an imbalance of maternal micronutrients increases Delta5 desaturase activity but decreases mRNA levels, decreases Delta6 desaturase activity but not mRNA levels as compared to control.
    Title: Effect of maternal micronutrients (folic acid, vitamin B12) and omega 3 fatty acids on liver fatty acid desaturases and transport proteins in Wistar rats.
  2. Regulation of 5-desaturase expression is different in female vs. male liver (but not cerebral cortex) during n-3 fatty acid repletion.
    Title: Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion.
  3. support a significant role for reverse Delta5-desaturase as a natural antisense regulator of Delta5-desaturase
    Title: A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acyl-CoA delta5-desaturase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyl-CoA delta5-desaturase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA delta5-desaturase activity ISO
Inferred from Sequence Orthology
more info
  
enables linoleoyl-CoA desaturase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to isolation stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to sucrose IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to vitamin A IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in unsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within unsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in unsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
acyl-CoA (8-3)-desaturase
Names
D5D
delta(5) desaturase
delta(5) fatty acid desaturase
NP_445897.2
XP_006231137.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053445.2 → NP_445897.2  acyl-CoA (8-3)-desaturase

    See identical proteins and their annotated locations for NP_445897.2

    Status: PROVISIONAL

    Source sequence(s)
    AB052085
    UniProtKB/Swiss-Prot
    Q920R3, Q9EPV4
    UniProtKB/TrEMBL
    A6I010, H2BF30
    Related
    ENSRNOP00000027834.4, ENSRNOT00000027834.5
    Conserved Domains (2) summary
    PLN03198
    Location:13 → 435
    PLN03198; delta6-acyl-lipid desaturase; Provisional
    cd03506
    Location:165 → 415
    Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216252605..216267618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231075.5 → XP_006231137.1  acyl-CoA (8-3)-desaturase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYM0, H2BF30
    Related
    ENSRNOP00000083085.1
    Conserved Domains (3) summary
    PLN03199
    Location:12 → 466
    PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional
    cd03506
    Location:189 → 439
    Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
    pfam00173
    Location:21 → 96
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920R3.1 GenPept UniProtKB/Swiss-Prot:Q920R3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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