Slc7a8 solute carrier family 7 member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc7a8provided by RGD
Official Full Name: solute carrier family 7 member 8provided by RGD
Primary source: RGD:619904
See related: Ensembl:ENSRNOG00000014311 AllianceGenome:RGD:619904
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lat2; Lat4
Summary: Predicted to enable several functions, including neutral amino acid transmembrane transporter activity; peptide antigen binding activity; and thyroid hormone transmembrane transporter activity. Predicted to be involved in amino acid transport and thyroid hormone transport. Predicted to act upstream of or within L-amino acid transport. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and microvillus membrane. Orthologous to human SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 179.0), Adrenal (RPKM 148.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32153016..32212715, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28183013..28242717, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33369245..33428942, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of the present study suggested that SLC7A8 may serve a critical role in blood pressure control through regulating LDOPA uptake in renal epithelial cells of the proximal tubule.
Title: Increased SLC7A8 expression mediates L-DOPA uptake by renal tubular epithelial cells.
Data suggest that glucose deprivation sensitivity (model for ischemia) of LAT1 expression in retinal capillary endothelial cells is transcriptionally regulated, and cis-elements within LAT1 promoter region from -162 bp to -155 bp mediate this regulation.
Title: Up-regulation of L-type amino acid transporter 1 (LAT1) in cultured rat retinal capillary endothelial cells in response to glucose deprivation.
Reduced delivery of Arg due to enhanced y+ LAT2-mediated exchange of extracellular Gln for intracellular Arg may contribute to the decrease of nitric oxide/cyclic GMP pathway activity evoked in the brain by hyperammonemia.
Title: Hyperammonemia increases the expression and activity of the glutamine/arginine transporter y+ LAT2 in rat cerebral cortex: implications for the nitric oxide/cGMP pathway.
Differences in L-DOPA handling between SHR and WKY cells may result from over-expression of LAT1 and LAT2 transporters in the former.
Title: Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells.
Overexpression of renal LAT2 might contribute to enhanced L-DOPA uptake and precedes the onset of hypertension.
Title: Organ-specific overexpression of renal LAT2 and enhanced tubular L-DOPA uptake precede the onset of hypertension.
LAT1 and its subunit 4F2hc are highly expressed in the early stage of new bone formation and may have an important role in providing cells with neutral amino acids, including several essential amino acids, at that stage.
Title: Expression of amino acid transporter LAT1 and 4F2hc in the healing process after the implantation of a tooth ash and plaster of Paris mixture.

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General gene information

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Markers

RH124773 (e-PCR)
- UniSTS:161595

RH128326 (e-PCR)
- UniSTS:211634

D15Wox10 (e-PCR)
- UniSTS:518610

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-leucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables glycine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables thyroid hormone transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thyroid hormone transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-alanine import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in L-leucine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-leucine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in glycine transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in organic cation transport	IEA Inferred from Electronic Annotation more info
involved_in proline transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in tryptophan transport	ISO Inferred from Sequence Orthology more info
involved_in valine transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: large neutral amino acids transporter small subunit 2

Names: L-type amino acid transporter 2; cationic amino acid transporter y+ system; solute carrier family 7 (amino acid transporter light chain, L system), member 8; solute carrier family 7 (cationic amino acid transporter, y+ system), member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.