U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MCHR2 melanin concentrating hormone receptor 2 [ Homo sapiens (human) ]

Gene ID: 84539, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
MCHR2provided by HGNC
Official Full Name
melanin concentrating hormone receptor 2provided by HGNC
Primary source
HGNC:HGNC:20867
See related
Ensembl:ENSG00000152034 MIM:606111; AllianceGenome:HGNC:20867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLT; MCH2; MCH2R; GPR145; GPRv17; MCH-2R; MCH-R2; MCHR-2
Summary
Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 3.0) and testis (RPKM 2.4) See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MCHR2 in Genome Data Viewer
Location:
6q16.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (99918519..99994223, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (101091896..101168099, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (100366395..100442099, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene thiosulfate sulfurtransferase like domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:100023517-100023714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24863 Neighboring gene CCNC and PRDM13 intergenic region DNase I hypersensitve site DHS6S1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:100051429-100052268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:100061850-100062398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17423 Neighboring gene ribosomal protein S3 pseudogene 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:100097329-100097949 Neighboring gene PR/SET domain 13 Neighboring gene Sharpr-MPRA regulatory region 7231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:100271711-100272281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:100379521-100380020 Neighboring gene MCHR2 antisense RNA 1 Neighboring gene tetratricopeptide repeat domain 22 pseudogene Neighboring gene nucleophosmin 1 pseudogene 38

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DNA sequencing and copy number variation analysis of MCHR2 in a cohort of Prader Willi like (PWL) patients. Geets E, et al. Obes Res Clin Pract, 2018 Mar-Apr. PMID 29066024
  2. Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2. Fischer J, et al. Exp Dermatol, 2017 Jun. PMID 27306922
  3. Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2. Chen X, et al. Bioorg Med Chem Lett, 2012 Jan 1. PMID 22123324
  4. Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics. Yuan C, et al. Indian J Exp Biol, 2009 Nov. PMID 20099459
  5. A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder. Abou Jamra R, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jun 5. PMID 19927306

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results are in line with some previously performed studies suggesting that MCHR2 is not a major contributor to human obesity and the Prader Willi Syndrome phenotype
    Title: DNA sequencing and copy number variation analysis of MCHR2 in a cohort of Prader Willi like (PWL) patients.
  2. evidence for the involvement of duplications in MCHR2 in alopecia areata pathogenesis in a Central European cohort
    Title: Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2.
  3. This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression.
    Title: Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.
  4. Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2
    Title: Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.
  5. construction of the CHO cell line and the research of MCHR2 molecular characteristics have established a good experimental basis for the further research about the function of MCHR2 gene
    Title: Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics.
  6. MCHR2 positively mediates the regulation of melanin-concentrating hormone during preadipocyte differentiation and is involved in energy balance regulation without affecting preadipocyte proliferation.
    Title: Melanin-concentrating hormone receptor 2 affects 3T3-L1 preadipocyte differentiation.
  7. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder.
  9. MCHR2 is not a major contributor to polygenic obesity
    Title: Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.
  10. results of molecular simulations of MCHR2 in the free and hormone-bound forms provide suggestions on the amino acids responsible for the transfer of the structural changes from the agonist binding site to the G-protein coupling domains
    Title: Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
melanin-concentrating hormone receptor 2
Names
G protein-coupled receptor slt
G-protein coupled receptor 145
MCH receptor 2
melanin-concentrating hormone 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040179.2 → NP_001035269.1  melanin-concentrating hormone receptor 2

    See identical proteins and their annotated locations for NP_001035269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK123634, AL590725
    Consensus CDS
    CCDS5044.1
    UniProtKB/Swiss-Prot
    B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8
    Related
    ENSP00000281806.2, ENST00000281806.7
    Conserved Domains (1) summary
    cd15339
    Location:35 → 317
    7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_032503.3 → NP_115892.2  melanin-concentrating hormone receptor 2

    See identical proteins and their annotated locations for NP_115892.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK123634, AL590725
    Consensus CDS
    CCDS5044.1
    UniProtKB/Swiss-Prot
    B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8
    Related
    ENSP00000358214.1, ENST00000369212.2
    Conserved Domains (1) summary
    cd15339
    Location:35 → 317
    7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    99918519..99994223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446571.2 → XP_024302339.1  melanin-concentrating hormone receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8
    Conserved Domains (1) summary
    cd15339
    Location:35 → 317
    7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    101091896..101168099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356560.1 → XP_054212535.1  melanin-concentrating hormone receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969V1.1 GenPept UniProtKB/Swiss-Prot:Q969V1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous