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Tec tec protein tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 84492, updated on 11-Apr-2024

Summary

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Official Symbol
Tecprovided by RGD
Official Full Name
tec protein tyrosine kinaseprovided by RGD
Primary source
RGD:620973
See related
Ensembl:ENSRNOG00000002278 AllianceGenome:RGD:620973
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in tissue regeneration. Predicted to be located in cell-cell junction; cytoskeleton; and plasma membrane. Orthologous to human TEC (tec protein tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 121.4), Liver (RPKM 93.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (35706557..35815563)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (35352551..35461585)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (37918884..38027953)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SLAIN motif family, member 2 Neighboring gene glutathione peroxidase 4, pseudogene 3 Neighboring gene TXK tyrosine kinase Neighboring gene NIPA-like domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF. Li F, et al. Biochem Biophys Res Commun, 2011 Jan 7. PMID 21094130
  2. Identification and characterization of differentially expressed genes in the early response phase during liver regeneration. Xu W, et al. Biochem Biophys Res Commun, 2000 Nov 19. PMID 11097837
  3. Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets. Hamazaki Y, et al. Oncogene, 1998 May 28. PMID 9652744
  4. Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets. Laffargue M, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299487
  5. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Ohya K, et al. Proc Natl Acad Sci U S A, 1999 Oct 12. PMID 10518561, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
  
involved_in tissue regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Tec
Names
cytoplasmic tyrosine kinase, Dscr28C related
NP_445884.1
XP_038948440.1
XP_038948441.1
XP_038948442.1
XP_063129753.1
XP_063129754.1
XP_063129755.1
XP_063129756.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053432.1 → NP_445884.1  tyrosine-protein kinase Tec

    See identical proteins and their annotated locations for NP_445884.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166730
    UniProtKB/TrEMBL
    A0A8I5ZXG2, B2RYC7
    Related
    ENSRNOP00000003125.5, ENSRNOT00000003125.6
    Conserved Domains (4) summary
    cd10396
    Location:238 → 345
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:181 → 235
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:363 → 622
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    35706557..35815563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273685.1 → XP_063129755.1  tyrosine-protein kinase Tec isoform X1

    UniProtKB/TrEMBL
    A0A8I6A3K6

  2. XM_039092512.2 → XP_038948440.1  tyrosine-protein kinase Tec isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZXG2, B2RYC7
    Related
    ENSRNOP00000075313.1
    Conserved Domains (4) summary
    cd10396
    Location:238 → 345
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:181 → 235
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:363 → 622
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

  3. XM_063273683.1 → XP_063129753.1  tyrosine-protein kinase Tec isoform X1

    UniProtKB/TrEMBL
    A0A8I6A3K6

  4. XM_039092513.2 → XP_038948441.1  tyrosine-protein kinase Tec isoform X4

    Conserved Domains (4) summary
    cd10396
    Location:238 → 345
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:181 → 235
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cl21453
    Location:363 → 488
    PKc_like; Protein Kinases, catalytic domain

  5. XM_063273684.1 → XP_063129754.1  tyrosine-protein kinase Tec isoform X1

    UniProtKB/TrEMBL
    A0A8I6A3K6

  6. XM_063273686.1 → XP_063129756.1  tyrosine-protein kinase Tec isoform X3

  7. XM_039092514.2 → XP_038948442.1  tyrosine-protein kinase Tec isoform X5

    UniProtKB/TrEMBL
    Q9EQ78
    Conserved Domains (4) summary
    cd10396
    Location:156 → 263
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:99 → 153
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd05114
    Location:281 → 540
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
    cl17171
    Location:10 → 66
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

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