U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adcy7 adenylate cyclase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84420, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Adcy7provided by RGD
Official Full Name
adenylate cyclase 7provided by RGD
Primary source
RGD:619966
See related
Ensembl:ENSRNOG00000014776 AllianceGenome:RGD:619966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables adenylate cyclase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and maternal process involved in female pregnancy. Located in membrane. Orthologous to human ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 190.6), Lung (RPKM 141.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19p11
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (34913154..34972366, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (18740875..18798924, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (19702307..19762973, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483621 Neighboring gene uncharacterized LOC120098503 Neighboring gene bromodomain containing 7 Neighboring gene uncharacterized LOC134483299 Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene HEAT repeat containing 3 Neighboring gene uncharacterized LOC134483300

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Adenylyl cyclase isoforms in the vestibular periphery of the rat. Wackym PA, et al. Brain Res, 2000 Mar 24. PMID 10719090
  2. Changes in the expression of adenylyl cyclases in the rat uterus during the course of pregnancy. Suzuki Y, et al. Biol Reprod, 1997 Oct. PMID 9314580
  3. CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion. Alhaidan Y, et al. Front Endocrinol (Lausanne), 2021. PMID 34177802, Free PMC Article
  4. Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice. Duan B, et al. J Immunol, 2010 Jul 1. PMID 20505140, Free PMC Article
  5. Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons. Fan P, et al. Mol Pharmacol, 2009 Sep. PMID 19549762, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion.
    Title: CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ethanol ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lithium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in maternal process involved in female pregnancy IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of adaptive immune response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
adenylate cyclase type 7
Names
adenylyl cyclase 7
NP_445848.1
XP_017456870.1
XP_017456871.1
XP_017456872.1
XP_017456873.1
XP_017456877.1
XP_017456879.1
XP_017456880.1
XP_017456881.1
XP_017456882.1
XP_063134393.1
XP_063134394.1
XP_063134396.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053396.1 → NP_445848.1  adenylate cyclase type 7

    See identical proteins and their annotated locations for NP_445848.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6KDA2, F1LQT1
    Conserved Domains (3) summary
    pfam00211
    Location:891 → 1087
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:21 → 251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487 → 593
    DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    34913154..34972366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601393.3 → XP_017456882.1  adenylate cyclase type 7 isoform X1

    UniProtKB/TrEMBL
    A6KDA2, F1LQT1
    Conserved Domains (3) summary
    pfam00211
    Location:891 → 1087
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:21 → 251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487 → 593
    DUF1053; Domain of Unknown Function (DUF1053)

  2. XM_017601388.3 → XP_017456877.1  adenylate cyclase type 7 isoform X1

    UniProtKB/TrEMBL
    A6KDA2, F1LQT1
    Conserved Domains (3) summary
    pfam00211
    Location:891 → 1087
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:21 → 251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487 → 593
    DUF1053; Domain of Unknown Function (DUF1053)

  3. XM_063278323.1 → XP_063134393.1  adenylate cyclase type 7 isoform X1

    UniProtKB/TrEMBL
    A6KDA2, F1LQT1

  4. XM_017601391.3 → XP_017456880.1  adenylate cyclase type 7 isoform X1

    UniProtKB/TrEMBL
    A6KDA2, F1LQT1
    Conserved Domains (3) summary
    pfam00211
    Location:891 → 1087
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:21 → 251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487 → 593
    DUF1053; Domain of Unknown Function (DUF1053)

  5. XM_017601381.3 → XP_017456870.1  adenylate cyclase type 7 isoform X1

    UniProtKB/TrEMBL
    A6KDA2, F1LQT1
    Conserved Domains (3) summary
    pfam00211
    Location:891 → 1087
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:21 → 251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487 → 593
    DUF1053; Domain of Unknown Function (DUF1053)

  6. XM_017601382.3 → XP_017456871.1  adenylate cyclase type 7 isoform X1

    UniProtKB/TrEMBL
    A6KDA2, F1LQT1
    Related
    ENSRNOP00000020700.5
    Conserved Domains (3) summary
    pfam00211
    Location:891 → 1087
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:21 → 251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487 → 593
    DUF1053; Domain of Unknown Function (DUF1053)

  7. XM_017601384.3 → XP_017456873.1  adenylate cyclase type 7 isoform X1

    UniProtKB/TrEMBL
    A6KDA2, F1LQT1
    Conserved Domains (3) summary
    pfam00211
    Location:891 → 1087
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:21 → 251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487 → 593
    DUF1053; Domain of Unknown Function (DUF1053)

  8. XM_017601383.3 → XP_017456872.1  adenylate cyclase type 7 isoform X1

    UniProtKB/TrEMBL
    A6KDA2, F1LQT1
    Conserved Domains (3) summary
    pfam00211
    Location:891 → 1087
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:21 → 251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487 → 593
    DUF1053; Domain of Unknown Function (DUF1053)

  9. XM_017601390.3 → XP_017456879.1  adenylate cyclase type 7 isoform X1

    UniProtKB/TrEMBL
    A6KDA2, F1LQT1
    Conserved Domains (3) summary
    pfam00211
    Location:891 → 1087
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:21 → 251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487 → 593
    DUF1053; Domain of Unknown Function (DUF1053)

  10. XM_017601392.3 → XP_017456881.1  adenylate cyclase type 7 isoform X1

    UniProtKB/TrEMBL
    A6KDA2, F1LQT1
    Conserved Domains (3) summary
    pfam00211
    Location:891 → 1087
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:21 → 251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487 → 593
    DUF1053; Domain of Unknown Function (DUF1053)

  11. XM_063278324.1 → XP_063134394.1  adenylate cyclase type 7 isoform X2

  12. XM_063278326.1 → XP_063134396.1  adenylate cyclase type 7 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous