Slc34a2 solute carrier family 34 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc34a2provided by RGD
Official Full Name: solute carrier family 34 member 2provided by RGD
Primary source: RGD:620889
See related: Ensembl:ENSRNOG00000004626 AllianceGenome:RGD:620889
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein domain specific binding activity. Involved in several processes, including response to estradiol; response to fructose; and sodium-dependent phosphate transport. Located in apical plasma membrane; brush border membrane; and microvillus membrane. Human ortholog(s) of this gene implicated in pulmonary alveolar microlithiasis. Orthologous to human SLC34A2 (solute carrier family 34 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1945.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (62123313..62153020, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (57910931..57930236, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (60257211..60276516, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality.
Title: Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality.
This is the first evidence of an active Si transport protein in mammals and points towards an important role for Si in vertebrates and explains interactions between dietary phosphate and silicon.
Title: Identification of a mammalian silicon transporter.
that NHERF1 associates with NaPi-2b in enterocytes and regulates NaPi-2b adaptation.
Title: NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli.
NaPi-IIb is upregulated in the kidney in response to the active excretion of phosphate in HP diet-fed rats
Title: High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis.
Dexamethasone and cyclic AMP regulate sodium phosphate cotransporter (NaPi-IIb and Pit-1) mRNA and phosphate uptake in rat alveolar type II epithelial cells.
Title: Dexamethasone and cyclic AMP regulate sodium phosphate cotransporter (NaPi-IIb and Pit-1) mRNA and phosphate uptake in rat alveolar type II epithelial cells.
Intestinal NaPiIIb is the only phosphate transporter that can play a significant role in membrane transport of arsenate.
Title: Role of rat sodium/phosphate cotransporters in the cell membrane transport of arsenate.
The expression of NaPi-IIa and NaPi-IIb seem regulated by phosphate in a manner consistent with their playing a role in transcellular P(i) flux during mineralization.
Title: Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate.
NaPi-IIb (Slc34a2) is most probably involved in the reabsorption of P(i) from primary hepatic bile and thus might play an important role in the regulation of biliary P(i) concentration.
Title: Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver.

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General gene information

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Markers

RH127919 (e-PCR)
- UniSTS:211229

RH133883 (e-PCR)
- UniSTS:217166

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphate ion binding	IEA Inferred from Electronic Annotation more info
enables phosphate ion binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium ion binding	IEA Inferred from Electronic Annotation more info
enables sodium ion binding	ISO Inferred from Sequence Orthology more info
enables sodium:phosphate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:phosphate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:phosphate symporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:phosphate symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in intracellular phosphate ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular phosphate ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphate ion transport	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transport	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to fructose	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium-dependent phosphate transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium-dependent phosphate transport protein 2B

Names: Na(+)-dependent phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; naPi-2b; rNaPi IIb; sodium-phosphate transport protein 2B; sodium/phosphate cotransporter 2B; solute carrier family 34 (sodium phosphate), member 2; solute carrier family 34 (type II sodium/phosphate contransporter), member 2; solute carrier family 34 (type II sodium/phosphate cotransporter), member 2; type IIb sodium-phosphate transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053380.2 → NP_445832.1 sodium-dependent phosphate transport protein 2B

See identical proteins and their annotated locations for NP_445832.1

Status: PROVISIONAL

Source sequence(s)

BC070898

UniProtKB/Swiss-Prot

Q8VI55, Q9JJ09

UniProtKB/TrEMBL

A0A8I5ZXN1, A6IJG4

Related

ENSRNOP00000083766.1, ENSRNOT00000111481.1

Conserved Domains (1) summary

TIGR01013
Location:105 → 604

2a58; Phosphate:Na+ Symporter (PNaS) Family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

62123313..62153020 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273681.1 → XP_063129751.1 sodium-dependent phosphate transport protein 2B isoform X1

UniProtKB/Swiss-Prot

Q8VI55, Q9JJ09

UniProtKB/TrEMBL

A6IJG4