bco1 beta-carotene oxygenase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bco1provided by ZNC
Official Full Name: beta-carotene oxygenase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010508-1
See related: Ensembl:ENSDARG00000104256 AllianceGenome:ZFIN:ZDB-GENE-010508-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bcdo; bcox; bcdo1; bcmo1; b-diox; bcmo1a
Summary: Enables beta-carotene 15,15'-dioxygenase activity. Acts upstream of or within eye photoreceptor cell differentiation and hindbrain development. Is expressed in gut; liver; neural crest; ovary; and xanthophore. Orthologous to human BCO1 (beta-carotene oxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (65272470..65290474)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (65048442..65066446)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables beta-carotene 15,15'-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-carotene 15,15'-dioxygenase activity	IDA Inferred from Direct Assay more info
enables beta-carotene 15,15'-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables carotenoid dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	NAS Non-traceable Author Statement more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carotene catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info
involved_in retinal metabolic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beta,beta-carotene 15,15'-dioxygenase

Names: beta-carotene 15, 15'-dioxygenase; beta-carotene 15,15'-monooxygenase 1a

NP_001315424.1

EC 1.13.11.63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328495.1 → NP_001315424.1 beta,beta-carotene 15,15'-dioxygenase

Status: VALIDATED

Source sequence(s)

CU682354, CU856172

UniProtKB/TrEMBL

A0A8M1PAC3, Q7ZTS0

Related

ENSDARP00000137596.1, ENSDART00000162471.2

Conserved Domains (1) summary

pfam03055
Location:10 → 513

RPE65; Retinal pigment epithelial membrane protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

65272470..65290474

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_131798.2: Suppressed sequence

Description

NM_131798.2: This RefSeq was removed because currently there is insufficient support for the transcript.