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Gtf2a2 general transcription factor 2A subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83828, updated on 13-Apr-2024

Summary

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Official Symbol
Gtf2a2provided by RGD
Official Full Name
general transcription factor 2A subunit 2provided by RGD
Primary source
RGD:620720
See related
Ensembl:ENSRNOG00000056701 AllianceGenome:RGD:620720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including RNA polymerase II general transcription initiation factor activity; TBP-class protein binding activity; and protein dimerization activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cell junction and nucleoplasm. Predicted to be part of transcription factor TFIIA complex and transcription factor TFIID complex. Orthologous to human GTF2A2 (general transcription factor IIA subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 354.3), Muscle (RPKM 304.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (79542682..79556484)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (70662447..70675576)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (76422341..76435587)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094198 Neighboring gene BCL2 interacting protein 2 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene selenoprotein K, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The concept of compensation in cognitive aging: the case of prose processing in adulthood. Dixon RA, et al. Int J Aging Hum Dev, 1992-1993. PMID 1302244
  2. Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription. Ozer J, et al. Genes Dev, 1994 Oct 1. PMID 7958899
  3. Transcription factor IIA mutations show activator-specific defects and reveal a IIA function distinct from stimulation of TBP-DNA binding. Ozer J, et al. J Biol Chem, 1996 May 10. PMID 8626665
  4. Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription. Sun X, et al. Genes Dev, 1994 Oct 1. PMID 7958900
  5. Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription. DeJong J, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7724559, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC188808

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIA complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIA complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription initiation factor IIA subunit 2
Names
TFIIA-gamma
general transcription factor IIA subunit 2
general transcription factor IIa 2
general transcription factor IIa, 2 (12kD subunit)
general transcription factor2A subunit 2
transcription initiation factor IIA gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412186.1 → NP_001399115.1  transcription initiation factor IIA subunit 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    O08950
    UniProtKB/TrEMBL
    A6KEU8
    Related
    ENSRNOP00000068825.1, ENSRNOT00000085496.2

  2. NM_053345.2 → NP_445797.1  transcription initiation factor IIA subunit 2

    See identical proteins and their annotated locations for NP_445797.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    O08950
    UniProtKB/TrEMBL
    A6KEU8, A6KEU9
    Related
    ENSRNOP00000071778.2, ENSRNOT00000084148.2
    Conserved Domains (1) summary
    COG5123
    Location:3 → 103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

RNA

  1. NR_178067.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    79542682..79556484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266219.1 → XP_063122289.1  transcription initiation factor IIA subunit 2 isoform X1

  2. XM_063266221.1 → XP_063122291.1  transcription initiation factor IIA subunit 2 isoform X3

    UniProtKB/TrEMBL
    B5DEM4

  3. XM_063266222.1 → XP_063122292.1  transcription initiation factor IIA subunit 2 isoform X3

    UniProtKB/TrEMBL
    B5DEM4

  4. XM_063266220.1 → XP_063122290.1  transcription initiation factor IIA subunit 2 isoform X1

  5. XM_039082206.2 → XP_038938134.1  transcription initiation factor IIA subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    O08950
    UniProtKB/TrEMBL
    A6KEU8, A6KEU9
    Conserved Domains (1) summary
    COG5123
    Location:3 → 103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08950.1 GenPept UniProtKB/Swiss-Prot:O08950

Gene LinkOut

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