cry2 cryptochrome circadian regulator 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cry2provided by ZNC
Official Full Name: cryptochrome circadian regulator 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-010426-6
See related: Ensembl:ENSDARG00000102403 AllianceGenome:ZFIN:ZDB-GENE-010426-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cry3; zcry3; fe16d07; wu:fe16d07
Summary: Predicted to enable DNA binding activity and FAD binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated; response to light stimulus; and response to temperature stimulus. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including brain; eye; inner ear; liver; and pleuroperitoneal region. Orthologous to human CRY2 (cryptochrome circadian regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (13847458..13871118, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (13751058..13774755, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of zebrafish cryptochrome2 and 4 expression in UV cone photoreceptors.
Title: Analysis of zebrafish cryptochrome2 and 4 expression in UV cone photoreceptors.
zCRY1a, and zCRY2a function in synchronizing cellular clocks
Title: The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish.
Data indicate that magnetic receptor magnetoreceptor (MagR) and cryptochrome cry2 exist as a single copy gene, whereas cry1 exists as multiple gene duplicates (cry1aa, cry1ab, cry1ba and cry1bb).
Title: Identification of zebrafish magnetoreceptor and cryptochrome homologs.

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General gene information

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Markers

fc35b07.x1 (e-PCR)
- UniSTS:193624

fe16d07.x1 (e-PCR)
- UniSTS:196243

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock by photoperiod	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within response to light stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to temperature stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info

General protein information

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Preferred Names: cryptochrome-2

Names: cryptochrome 3; cryptochrome circadian clock 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131786.2 → NP_571861.2 cryptochrome-2

See identical proteins and their annotated locations for NP_571861.2

Status: PROVISIONAL

Source sequence(s)

BC046088

UniProtKB/TrEMBL

A0A8M1PCY7, Q7ZU53

Related

ENSDARP00000134736.1, ENSDART00000160866.2

Conserved Domains (3) summary

COG0415
Location:5 → 491

PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]

pfam00875
Location:5 → 169

DNA_photolyase; DNA photolyase

pfam03441
Location:213 → 486

FAD_binding_7; FAD binding domain of DNA photolyase