Ncoa2 nuclear receptor coactivator 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ncoa2provided by RGD
Full Name: nuclear receptor coactivator 2provided by RGD
Primary source: RGD:620108
See related: Ensembl:ENSRNOG00000007975 AllianceGenome:RGD:620108
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tif2; Grip1; GRIP-1
Summary: Enables DNA polymerase binding activity; PDZ domain binding activity; and nuclear receptor binding activity. Involved in several processes, including male gonad development; positive regulation of female receptivity; and positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including dendritic spine; postsynaptic density; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 104.1), Kidney (RPKM 98.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q11

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (10618712..10852776)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (5835642..6069693)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (5466544..5696540)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest that alterations of histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus and the inability of Ncoa2 and Crebbp to respond to estradiol in the middle-aged anterior hypothalamus partially contribute to the decline of GnRH neuron activation and estradiol target gene expression changes that occur in females along with reproductive aging.
Title: Alterations of estradiol-induced histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus of middle-aged female rats.
Binding of the N-terminal region of TIF2 to the AF1 domain of the glucocorticoid receptor changes both its conformation and transcriptional activity.
Title: Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations.
SRC-2 from brain interacts with ER and PR in a subtype-specific manner, which may contribute to the functional differences of these steroid receptor subtypes in brain.
Title: Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors.
In seminiferous tubules of mature rat testis TIF2 was expressed predominantly in Sertoli cells. In the epididymis, SRC-1 and TIF2 immunoreactivities were localized in nuclei of epithelial cells.
Title: Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis.
GR ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9
Title: Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables aryl hydrocarbon receptor binding	IEA Inferred from Electronic Annotation more info
enables aryl hydrocarbon receptor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear glucocorticoid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear retinoic acid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear retinoid X receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear thyroid hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to Thyroglobulin triiodothyronine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to Thyroglobulin triiodothyronine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in locomotor rhythm	IEA Inferred from Electronic Annotation more info
involved_in locomotor rhythm	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of female receptivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucocorticoid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to progesterone	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor coactivator 2

Names: NCoA-2; glucocorticoid receptor interacting protein 1; transcriptional intermediary factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031822.3 → NP_114010.2 nuclear receptor coactivator 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

F1MA61

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

10618712..10852776

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237744.5 → XP_006237806.1 nuclear receptor coactivator 2 isoform X1

See identical proteins and their annotated locations for XP_006237806.1

UniProtKB/Swiss-Prot

Q9WUI9

UniProtKB/TrEMBL

F1MA61

Conserved Domains (9) summary

cd00130
Location:123 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:970 → 1361

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18950
Location:28 → 91

bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

pfam07469
Location:1281 → 1338

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:1071 → 1115

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:636 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:268 → 378

PAS_11; PAS domain

pfam16279
Location:731 → 816

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:463 → 587

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_039110853.2 → XP_038966781.1 nuclear receptor coactivator 2 isoform X2

UniProtKB/Swiss-Prot

Q9WUI9

UniProtKB/TrEMBL

A0A8I6AJ68

Related

ENSRNOP00000093156.1

Conserved Domains (9) summary

cd00130
Location:123 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:901 → 1292

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18950
Location:28 → 91

bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

pfam07469
Location:1212 → 1269

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:1002 → 1046

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:636 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:268 → 378

PAS_11; PAS domain

pfam16279
Location:731 → 816

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:463 → 587

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_039110852.2 → XP_038966780.1 nuclear receptor coactivator 2 isoform X1

UniProtKB/Swiss-Prot

Q9WUI9

UniProtKB/TrEMBL

F1MA61

Conserved Domains (9) summary

cd00130
Location:123 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:970 → 1361

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18950
Location:28 → 91

bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

pfam07469
Location:1281 → 1338

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:1071 → 1115

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:636 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:268 → 378

PAS_11; PAS domain

pfam16279
Location:731 → 816

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:463 → 587

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_017593660.3 → XP_017449149.1 nuclear receptor coactivator 2 isoform X1

UniProtKB/Swiss-Prot

Q9WUI9

UniProtKB/TrEMBL

F1MA61

Conserved Domains (9) summary

cd00130
Location:123 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:970 → 1361

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18950
Location:28 → 91

bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

pfam07469
Location:1281 → 1338

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:1071 → 1115

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:636 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:268 → 378

PAS_11; PAS domain

pfam16279
Location:731 → 816

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:463 → 587

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_063288486.1 → XP_063144556.1 nuclear receptor coactivator 2 isoform X1

UniProtKB/TrEMBL

F1MA61
XM_063288485.1 → XP_063144555.1 nuclear receptor coactivator 2 isoform X1

UniProtKB/TrEMBL

F1MA61
XM_063288483.1 → XP_063144553.1 nuclear receptor coactivator 2 isoform X1

UniProtKB/TrEMBL

F1MA61
XM_063288484.1 → XP_063144554.1 nuclear receptor coactivator 2 isoform X1

UniProtKB/TrEMBL

F1MA61
XM_006237747.5 → XP_006237809.1 nuclear receptor coactivator 2 isoform X1

See identical proteins and their annotated locations for XP_006237809.1

UniProtKB/Swiss-Prot

Q9WUI9

UniProtKB/TrEMBL

F1MA61

Conserved Domains (9) summary

cd00130
Location:123 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:970 → 1361

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18950
Location:28 → 91

bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

pfam07469
Location:1281 → 1338

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:1071 → 1115

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:636 → 709

SRC-1; Steroid receptor coactivator

pfam14598
Location:268 → 378

PAS_11; PAS domain

pfam16279
Location:731 → 816

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:463 → 587

NCOA_u2; Unstructured region on nuclear receptor coactivator protein