Bicc1 BicC family RNA binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bicc1provided by MGI
Official Full Name: BicC family RNA binding protein 1provided by MGI
Primary source: MGI:MGI:1933388
See related: Ensembl:ENSMUSG00000014329 AllianceGenome:MGI:1933388
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: bpk; jcpk; Bic-C
Summary: Predicted to enable RNA binding activity. Acts upstream of or within determination of left/right symmetry; heart development; and kidney development. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; embryo mesenchyme; gonad; intraembryonic coelom; and sensory organ. Used to study autosomal dominant polycystic kidney disease; autosomal recessive polycystic kidney disease; cystic kidney disease; and visceral heterotaxy. Human ortholog(s) of this gene implicated in diffuse cystic renal dysplasia. Orthologous to human BICC1 (BicC family RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 21.7), ovary adult (RPKM 11.9) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B5.3; 10 36.75 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (70758660..70995581, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (70922830..71159690, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and Regulatory Network Analysis of BICC1 for Aged Sca-1-Positive Bone Narrow Mesenchymal Stem Cells.
Title: Expression and Regulatory Network Analysis of BICC1 for Aged Sca-1-Positive Bone Narrow Mesenchymal Stem Cells.
Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
Title: Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
Study finding that Bicc1 is required for normoglycemia implies that renal gluconeogenesis may be important to inhibit cyst formation.
Title: Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex.
Polymerization is a novel disease-relevant mechanism both to stabilize Bicc1 and to present associated mRNAs in specific silencing platforms.
Title: Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA.
discovered that loss of the Pkd1 gene product, polycystin-1 (PC1), whose mutation causes human autosomal dominant polycystic kidney disease (ADPKD), downregulates Bicc1 expression in vitro and in vivo
Title: Loss of polycystin-1 inhibits Bicc1 expression during mouse development.
identify Bicc1 as a genetic determinant of osteoblastogenesis and BMD and suggest that it does so by regulating Pkd2 transcript levels
Title: Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.
Bicc1 similarly induces silencing of the protein kinase inhibitor PKIalpha by miR-27a.
Title: Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.
Bicc1 is a novel regulator of osteoblastogenesis and bone mineral density (BMD)
Title: Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.
Bicc1 KH domains bind the 3' UTRs of AC6 and PKIa mRNAs and cognate miRNA precursors, whereas the SAM domain loads a silencing complex with AGO2. AC6 and PKIa protein levels increase in cystic Bicc1-/- mouse kidneys.
Title: Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.
lack of Bicc1 leads to disruption of normal cell-cell junctions.
Title: Loss of Bicc1 impairs tubulomorphogenesis of cultured IMCD cells by disrupting E-cadherin-based cell-cell adhesion.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Chemically induced (other) (2) 1 citation
Targeted (2) 1 citation
Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Markers

Bicc1 (e-PCR), detects polymorphism
- UniSTS:479075

Bicc1 (e-PCR), detects polymorphism
- UniSTS:275851

Bicc1 (e-PCR), detects polymorphism
- UniSTS:275852

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISA Inferred from Sequence Alignment more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein bicaudal C homolog 1

Names: bicaudal C homolog 1; juvenile congenital polycystic kidney disease; polycystic kidney mutation of BALB/c origin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347189.1 → NP_001334118.1 protein bicaudal C homolog 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC079680, AC087891, AK076154, BX637408, CX207788, CX237497

Consensus CDS

CCDS83710.1

UniProtKB/TrEMBL

G3X8S6

Related

ENSMUSP00000014473.6, ENSMUST00000014473.6

Conserved Domains (4) summary

cd09520
Location:875 → 933

SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily

cd22420
Location:48 → 128

KH-I_BICC1_rpt1; first type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins

cd22421
Location:133 → 202

KH-I_BICC1_rpt2; second type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins

cd22422
Location:286 → 351

KH-I_BICC1_rpt3; third type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
NM_031397.3 → NP_113574.1 protein bicaudal C homolog 1 isoform 1

See identical proteins and their annotated locations for NP_113574.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC079680, AC087891, AK076154, BM936635, BX637408, CX207788, CX237497

Consensus CDS

CCDS23915.1

UniProtKB/Swiss-Prot

Q6P6K3, Q8C286, Q99MQ1

Related

ENSMUSP00000123201.2, ENSMUST00000143791.8

Conserved Domains (3) summary

cd09520
Location:875 → 938

SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily

smart00454
Location:878 → 935

SAM; Sterile alpha motif

cd02394
Location:136 → 202

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

70758660..70995581 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156124.1 → XP_036012017.1 protein bicaudal C homolog 1 isoform X1

Conserved Domains (4) summary

cd09520
Location:874 → 937

SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily

cd22420
Location:48 → 128

KH-I_BICC1_rpt1; first type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins

cd22421
Location:133 → 202

KH-I_BICC1_rpt2; second type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins

cd22422
Location:286 → 351

KH-I_BICC1_rpt3; third type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins