Thbd thrombomodulin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Thbdprovided by RGD
Official Full Name: thrombomodulinprovided by RGD
Primary source: RGD:621299
See related: Ensembl:ENSRNOG00000004687 AllianceGenome:RGD:621299
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Involved in response to X-ray; response to cAMP; and response to lipopolysaccharide. Located in apicolateral plasma membrane; extracellular space; and vacuolar membrane. Used to study acute kidney failure. Biomarker of adult respiratory distress syndrome; hypertension; ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (156316526..156320178, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (135863366..135867018, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (142748673..142752325, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that Thbd increases in male rat with aneurysmal subarachnoid hemorrhage.
Title: Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage.
Cellular and soluble levels of thrombomodulin are modified by cold stress in healthy rats, possibly via catecholamines and HSF1.
Title: Changes in cardiac thrombomodulin and heat shock transcription factor 1 expression and peripheral thrombomodulin and catecholamines during hypothermia in rats.
The expression of thrombomodulin and endothelial protein C receptor mRNAs of rats after paraquat intoxication is increased, and can significantly be decreased after administered with Na-DMPS.
Title: [Expression of thrombomodulin, endothelial protein C receptor in lung tissue of acute paraquat poisoned rats and intervention of sodium dimercaptopropane sulfonate].
Data show that bladder wall distension leads to PDGF receptor activation and identify thrombomodulin as an Akt and Fra-1 target in smooth muscle cells.
Title: An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration.
Activated protein C could augment the anti-coagulation and anti-inflammatory activity by up-regulating endothelial cell protein C receptor and thrombomodulin expression, thus attenuating the severity of severe acute pancreatis.
Title: Activated protein C improves the severity of severe acute pancreatitis via up-regulating the expressions of endothelial cell protein C receptor and thrombomodulin.
Intestinal irradiation up-regulates PAR-1 and causes a dose-dependent, sustained deficiency of microvascular Thrombomodulin that is independently associated with the severity of radiation toxicity.
Title: Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis.
Rapid atrial pacing acutely downregulated the gene expression of thrombomodulin and TFPI in rat atrial endocardium, thereby inducing local coagulation imbalance on the internal surface of the atrial cavity
Title: Thrombomodulin and tissue factor pathway inhibitor in endocardium of rapidly paced rat atria.
Decreased thrombomodulin expression in sinusoidal endothelial cells of LPS-treated rats may result in intrasinusoidal microthrombus formation and subsequent liver dysfunction during sepsis.
Title: Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats -- a possible mechanism of intrasinusoidal microthrombus formation and liver dysfunction.
TM was localized on the plasma membrane of the pericryptal fibroblasts which existed in the pericryptal spaces between the basal lamina of the epithelium and the collagenous sheets around the base of the crypt.
Title: Localization of thrombomodulin in pericryptal fibroblasts of the rat duodenum.
In cultured VECs from OLETF rats, the basal mRNA expressions of u-PA and TM were significantly decreased; TM mRNA expression in cultured VECs from OLETF rats was increased 2.1-fold at 24 h after treatment with db-cAMP
Title: Elevation of intracellular cAMP up-regulated thrombomodulin mRNA in cultured vascular endothelial cells derived from spontaneous type-II diabetes mellitus model rat.

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General gene information

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Markers

Thbd (e-PCR), detects polymorphism
- UniSTS:525950

RH128562 (e-PCR)
- UniSTS:211870

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in response to X-ray	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of serine-type endopeptidase complex	ISO Inferred from Sequence Orthology more info
located_in vacuolar membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thrombomodulin

Names: thrombomdulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031771.2 → NP_113959.1 thrombomodulin precursor

See identical proteins and their annotated locations for NP_113959.1

Status: PROVISIONAL

Source sequence(s)

BC070903

UniProtKB/TrEMBL

A6K7B7, F7EK87, O35370

Related

ENSRNOP00000006200.1, ENSRNOT00000006200.4

Conserved Domains (5) summary

pfam06247
Location:346 → 467

Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28

pfam07645
Location:324 → 360

EGF_CA; Calcium-binding EGF domain

pfam09064
Location:405 → 438

Tme5_EGF_like; Thrombomodulin like fifth domain, EGF-like

pfam14670
Location:244 → 279

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl02432
Location:30 → 169

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain