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Rxrg retinoid X receptor gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 83574, updated on 11-Apr-2024

Summary

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Symbol
Rxrgprovided by RGD
Full Name
retinoid X receptor gammaprovided by RGD
Primary source
RGD:620046
See related
Ensembl:ENSRNOG00000004537 AllianceGenome:RGD:620046
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; nuclear receptor activity; and retinoic acid-responsive element binding activity. Involved in several processes, including nervous system development; regulation of myelination; and response to retinoic acid. Located in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 248.0), Muscle (RPKM 230.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rxrg in Genome Data Viewer
Location:
13q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (82276330..82318097)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (79743430..79785173)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (85818473..85868555)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352569 Neighboring gene leucine rich repeat containing 52 Neighboring gene uncharacterized LOC102553924 Neighboring gene LIM homeobox transcription factor 1 alpha Neighboring gene uncharacterized LOC134481529 Neighboring gene probable serine/threonine-protein kinase dyrk1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Antiestrogenic activity of vitamin A in in vivo uterotrophic assay. Koda T, et al. Life Sci, 2007 Feb 13. PMID 17161848
  2. Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons. Cimini A, et al. Neuroscience, 2005. PMID 15664689
  3. Regulation of retinoid X receptor-gamma gene transcript levels in rat heart cells. Georgiades P, et al. Cell Biol Int, 1998. PMID 10328854
  4. Differential expression of the rat retinoid X receptor gamma gene during skeletal muscle differentiation suggests a role in myogenesis. Georgiades P, et al. Dev Dyn, 1997 Nov. PMID 9389449
  5. miR‑330‑5p inhibits H2O2‑induced adipogenic differentiation of MSCs by regulating RXRγ. Huang W, et al. Int J Mol Med, 2018 Oct. PMID 30015907, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the results of the present study revealed that miR3305p acts as a critical regulator of RXRgamma, and is able to determinate the fate of MSCs to differentiate into adipocytes. This suggests that miR3305p and RXRgamma may be target molecules for controlling metabolic diseases.
    Title: miR‑330‑5p inhibits H2O2‑induced adipogenic differentiation of MSCs by regulating RXRγ.
  2. RXRgamma was absent in the female rat brain, while it was observed in some regions in the male.
    Title: Expression of retinoic acid receptors and retinoid X receptors in normal and vitamin A deficient adult rat brain.
  3. These results suggest that HIF-1 may be involved in hypoxia-induced suppression of fatty acid metabolism in cardiomyocytes by reducing the DNA binding activity of PPARalpha/RXR.
    Title: Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor.
  4. Ectopic expression of PPARgamma/RXRalpha increases fatty acid uptake and deposition as triacylglycerides.
    Title: Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC109416

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular condensate scaffold activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables retinoic acid-responsive element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neuron differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in peripheral nervous system development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of myelination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to retinoic acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in retinoic acid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
retinoic acid receptor RXR-gamma
Names
RXR gamma-1
nuclear receptor subfamily 2 group B member 3
retinoic X receptor gamma-1
retinoic acid receptor RXR-gamma-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031765.1 → NP_113953.1  retinoic acid receptor RXR-gamma

    See identical proteins and their annotated locations for NP_113953.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091363
    UniProtKB/Swiss-Prot
    Q5BJR8
    UniProtKB/TrEMBL
    A0A0G2JZ22, A6IDL7
    Related
    ENSRNOP00000070882.2, ENSRNOT00000077227.2
    Conserved Domains (3) summary
    cd06943
    Location:233 → 441
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:137 → 213
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:25 → 133
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    82276330..82318097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091122.2 → XP_038947050.1  retinoic acid receptor RXR-gamma isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZ22, A0A8L2Q373
    Related
    ENSRNOP00000006117.5
    Conserved Domains (3) summary
    cd06943
    Location:233 → 442
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:137 → 213
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:25 → 133
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

  2. XM_039091123.2 → XP_038947051.1  retinoic acid receptor RXR-gamma isoform X2

    UniProtKB/TrEMBL
    Q64116
    Conserved Domains (2) summary
    cd06943
    Location:110 → 319
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:14 → 90
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BJR8.1 GenPept UniProtKB/Swiss-Prot:Q5BJR8

Gene LinkOut

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