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Aplnr apelin receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 83518, updated on 7-Jan-2025

Summary

Official Symbol
Aplnrprovided by RGD
Official Full Name
apelin receptorprovided by RGD
Primary source
RGD:621645
See related
EnsemblRapid:ENSRNOG00000009227 AllianceGenome:RGD:621645
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Apj; Agtrl1
Summary
Predicted to enable apelin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of body fluid levels. Located in plasma membrane. Orthologous to human APLNR (apelin receptor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Aplnr in Genome Data Viewer
Location:
3q24
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90624055..90627700)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (70217407..70221052)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72540538..72544183)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 3 Neighboring gene structure specific recognition protein 1 Neighboring gene tankyrase 1 binding protein 1 Neighboring gene leucine rich repeat containing 55 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 39
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway PubMed 
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway PubMed 
involved_in adult heart development  
involved_in angiogenesis  
involved_in aorta development  
involved_in apelin receptor signaling pathway  
involved_in atrioventricular valve development  
involved_in blood vessel development  
involved_in coronary vasculature development  
involved_in coronary vasculature development  
involved_in endocardial cushion formation  
involved_in gastrulation  
involved_in heart development  
involved_in heart development  
involved_in heart looping  
involved_in negative regulation of cAMP-mediated signaling  
involved_in negative regulation of cAMP-mediated signaling  
involved_in negative regulation of cAMP-mediated signaling  
acts_upstream_of negative regulation of gene expression  
involved_in positive regulation of G protein-coupled receptor internalization  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
involved_in positive regulation of release of sequestered calcium ion into cytosol  
involved_in positive regulation of release of sequestered calcium ion into cytosol  
involved_in regulation of body fluid levels PubMed 
acts_upstream_of_or_within regulation of gap junction assembly  
involved_in regulation of gene expression  
involved_in vascular associated smooth muscle cell differentiation  
involved_in vasculature development  
involved_in vasculogenesis  
involved_in vasculogenesis  
involved_in venous blood vessel development  
involved_in ventricular septum morphogenesis  
Items 1 - 25 of 39
Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
apelin receptor
Names
B78
G-protein coupled receptor APJ
GPCR34
angiotensin receptor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031349.2NP_112639.1  apelin receptor

    See identical proteins and their annotated locations for NP_112639.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072494
    UniProtKB/Swiss-Prot
    Q9ESK2, Q9JHG3
    UniProtKB/TrEMBL
    A6HMT5
    Related
    ENSRNOP00000012379.4, ENSRNOT00000012379.6
    Conserved Domains (1) summary
    cd15190
    Location:17318
    7tmA_Apelin_R; apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    90624055..90627700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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