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Slc7a7 solute carrier family 7 member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83509, updated on 11-Apr-2024

Summary

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Official Symbol
Slc7a7provided by RGD
Official Full Name
solute carrier family 7 member 7provided by RGD
Primary source
RGD:619902
See related
Ensembl:ENSRNOG00000010296 AllianceGenome:RGD:619902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
y+LAT1
Summary
Predicted to enable L-amino acid transmembrane transporter activity and basic amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and regulation of arginine metabolic process. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in lysinuric protein intolerance. Orthologous to human SLC7A7 (solute carrier family 7 member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 446.1), Spleen (RPKM 61.8) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p13
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (31792122..31852732, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (27822088..27873121, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33013346..33059733, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352920 Neighboring gene OXA1L, mitochondrial inner membrane protein Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene matrix metallopeptidase 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene. Torrents D, et al. Nat Genet, 1999 Mar. PMID 10080182
  2. Up-regulation of L type amino acid transporter 1 after spinal cord injury in rats. Toyooka T, et al. Acta Neurochir Suppl, 2008. PMID 19388351
  3. Five novel SLC7A7 variants and y+L gene-expression pattern in cultured lymphoblasts from Japanese patients with lysinuric protein intolerance. Shoji Y, et al. Hum Mutat, 2002 Nov. PMID 12402335
  4. Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets. Böhme E, et al. Adv Cyclic Nucleotide Res, 1978. PMID 27075
  5. Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance. Sperandeo MP, et al. Am J Physiol Cell Physiol, 2007 Jul. PMID 17376816

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-arginine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables basic amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables basic amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-arginine transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-leucine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-leucine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within basic amino acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of arginine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of arginine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Y+L amino acid transporter 1
Names
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
y(+)L-type amino acid transporter 1
y+LAT-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031341.2 → NP_112631.1  Y+L amino acid transporter 1

    See identical proteins and their annotated locations for NP_112631.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    Q9QZ66, Q9R0S5
    UniProtKB/TrEMBL
    A6KGS5, A6KGT1
    Related
    ENSRNOP00000014391.3, ENSRNOT00000014391.6
    Conserved Domains (1) summary
    TIGR00911
    Location:24 → 496
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    31792122..31852732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274696.1 → XP_063130766.1  Y+L amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ66, Q9R0S5
    UniProtKB/TrEMBL
    A6KGT1

  2. XM_008770705.4 → XP_008768927.1  Y+L amino acid transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_008768927.1

    UniProtKB/Swiss-Prot
    Q9QZ66, Q9R0S5
    UniProtKB/TrEMBL
    A6KGS5, A6KGT1
    Conserved Domains (1) summary
    TIGR00911
    Location:24 → 496
    2A0308; L-type amino acid transporter

  3. XM_039093692.2 → XP_038949620.1  Y+L amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ66, Q9R0S5
    UniProtKB/TrEMBL
    A6KGS5, A6KGT1
    Conserved Domains (1) summary
    TIGR00911
    Location:24 → 496
    2A0308; L-type amino acid transporter

  4. XM_039093693.2 → XP_038949621.1  Y+L amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ66, Q9R0S5
    UniProtKB/TrEMBL
    A6KGS5, A6KGT1
    Conserved Domains (1) summary
    TIGR00911
    Location:24 → 496
    2A0308; L-type amino acid transporter

  5. XM_039093695.1 → XP_038949623.1  Y+L amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ66, Q9R0S5
    UniProtKB/TrEMBL
    A6KGS5, A6KGT1
    Conserved Domains (1) summary
    TIGR00911
    Location:24 → 496
    2A0308; L-type amino acid transporter

  6. XM_039093696.2 → XP_038949624.1  Y+L amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ66, Q9R0S5
    UniProtKB/TrEMBL
    A6KGS5, A6KGT1
    Conserved Domains (1) summary
    TIGR00911
    Location:24 → 496
    2A0308; L-type amino acid transporter

  7. XM_039093694.2 → XP_038949622.1  Y+L amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ66, Q9R0S5
    UniProtKB/TrEMBL
    A6KGS5, A6KGT1
    Conserved Domains (1) summary
    TIGR00911
    Location:24 → 496
    2A0308; L-type amino acid transporter

  8. XM_006252020.5 → XP_006252082.1  Y+L amino acid transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006252082.1

    UniProtKB/Swiss-Prot
    Q9QZ66, Q9R0S5
    UniProtKB/TrEMBL
    A6KGS5, A6KGT1
    Conserved Domains (1) summary
    TIGR00911
    Location:24 → 496
    2A0308; L-type amino acid transporter

  9. XM_006252023.5 → XP_006252085.1  Y+L amino acid transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006252085.1

    UniProtKB/Swiss-Prot
    Q9QZ66, Q9R0S5
    UniProtKB/TrEMBL
    A6KGS5, A6KGT1
    Conserved Domains (1) summary
    TIGR00911
    Location:24 → 496
    2A0308; L-type amino acid transporter

  10. XM_039093698.2 → XP_038949626.1  Y+L amino acid transporter 1 isoform X2

    Conserved Domains (1) summary
    TIGR00911
    Location:2 → 269
    2A0308; L-type amino acid transporter

  11. XM_039093699.2 → XP_038949627.1  Y+L amino acid transporter 1 isoform X3

    Conserved Domains (1) summary
    TIGR00911
    Location:27 → 263
    2A0308; L-type amino acid transporter

  12. XM_063274698.1 → XP_063130768.1  Y+L amino acid transporter 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0S5.1 GenPept UniProtKB/Swiss-Prot:Q9R0S5

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