Cdh1 cadherin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdh1provided by RGD
Official Full Name: cadherin 1provided by RGD
Primary source: RGD:69279
See related: Ensembl:ENSRNOG00000020151 AllianceGenome:RGD:69279
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including GTPase activating protein binding activity; alpha-catenin binding activity; and ankyrin binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to toxic substance. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 264.9), Lung (RPKM 250.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (51402178..51471572)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (34492371..34561775)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (38768467..38838395)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E-cadherin/beta-catenin expression is conserved in human and rat erythropoiesis and marks stress erythropoiesis.
Title: E-cadherin/β-catenin expression is conserved in human and rat erythropoiesis and marks stress erythropoiesis.
Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema.
Title: Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema.
CDH1 is Identified as A Therapeutic Target for Skin Regeneration after Mechanical Loading.
Title: CDH1 is Identified as A Therapeutic Target for Skin Regeneration after Mechanical Loading.
Hsc70 is required for E-cadherin expression in epithelial-like NRK-52E cells.
Title: Hsc70 is required for E-cadherin expression in epithelial-like NRK-52E cells.
Radiation-induced H3K9 tri-methylation in E-cadherin promoter during lung EMT: in vitro and in vivo approaches using vanillin.
Title: Radiation-induced H3K9 tri-methylation in E-cadherin promoter during lung EMT: in vitro and in vivo approaches using vanillin.
Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood.
Title: Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood.
Study observed increased protein levels of E-cadherin in extracellular vesicles in breast cancer; furthermore, Tspan8 and p120-catenin were co-immunoprecipitated, indicating that they may interact with each other.
Title: Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles.
Cdh1 overexpression exerts a neuroprotective effect by regulating hippocampal neuroplasticity in global cerebral ischemia.
Title: Cdh1 overexpression improves emotion and cognitive-related behaviors via regulating hippocampal neuroplasticity in global cerebral ischemia rats.
Cdh1 overexpression increased the survival rates in animals with transient global cerebral ischemia.
Title: Upregulation of Cdh1 signaling in the hippocampus attenuates brain damage after transient global cerebral ischemia in rats.
Our findings indicate that neuron-derived ADAM10 production stimulates peripheral nerve injury-induced neuropathic pain by cleaving E-cadherin in satellite glial cells.
Title: Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127400 (e-PCR)
- UniSTS:210710

GDB:361098 (e-PCR)
- UniSTS:156729

D19Rat46 (e-PCR)
- UniSTS:118485

Cdh1 (e-PCR), detects polymorphism
- UniSTS:547826

Cdh1 (e-PCR), detects polymorphism
- UniSTS:141303

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activating protein binding	ISO Inferred from Sequence Orthology more info
enables alpha-catenin binding	ISO Inferred from Sequence Orthology more info
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in adherens junction organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to indole-3-methanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lithium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlea development	ISO Inferred from Sequence Orthology more info
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in decidualization	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intestinal epithelial cell development	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IEP Inferred from Expression Pattern more info	PubMed
involved_in pituitary gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in response to Gram-positive bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within salivary gland cavitation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trophectodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in uterine epithelium development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
located_in apical junction complex	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
part_of flotillin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of flotillin complex	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lateral loop	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in node of Ranvier	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin-1

Names: E-cadherin; epithelial cadherin; uvomorulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031334.1 → NP_112624.1 cadherin-1 precursor

See identical proteins and their annotated locations for NP_112624.1

Status: PROVISIONAL

Source sequence(s)

AB017696

UniProtKB/Swiss-Prot

O35794, Q9JIV9, Q9R0T4

UniProtKB/TrEMBL

A0A8I6G230, A6IYX4

Related

ENSRNOP00000027346.1, ENSRNOT00000027346.3

Conserved Domains (5) summary

cd00031
Location:162 → 262

CA_like; Cadherin repeat-like domain

cd11304
Location:270 → 375

Cadherin_repeat; Cadherin tandem repeat domain

pfam00028
Location:608 → 690

Cadherin; Cadherin domain

pfam01049
Location:745 → 881

Cadherin_C; Cadherin cytoplasmic region

pfam08758
Location:31 → 120

Cadherin_pro; Cadherin prodomain like