U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Psmd4 proteasome 26S subunit ubiquitin receptor, non-ATPase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83499, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Psmd4provided by RGD
Official Full Name
proteasome 26S subunit ubiquitin receptor, non-ATPase 4provided by RGD
Primary source
RGD:621109
See related
Ensembl:ENSRNOG00000021042 AllianceGenome:RGD:621109
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 474.1), Heart (RPKM 414.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185287941..185297238, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182598934..182608250, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196198303..196207569, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase beta Neighboring gene uncharacterized LOC102547008 Neighboring gene zinc finger protein 687 Neighboring gene uncharacterized LOC134485649 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons. Huang Q, et al. J Biol Chem, 2013 Apr 26. PMID 23508964, Free PMC Article
  2. Distribution and immunoregulatory properties of antisecretory factor. Davidson TS, et al. Lab Invest, 2004 Mar. PMID 14767482
  3. Molecular cloning and expression of rat antisecretory factor and its intracellular localization. Tateishi K, et al. Biochem Cell Biol, 1999. PMID 10505793
  4. [Expression of antisecretory factor and aquaporin 1, 2 in the rat inner ear and their interaction]. Li MN, et al. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2007 Apr. PMID 17628981
  5. The interaction of angiocidin with tissue transglutaminase. L'Heureux DZ, et al. Exp Mol Pathol, 2010 Feb. PMID 19931242, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons.
    Title: Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons.
  2. Antisecretory factor was widely distributed in the inner ear. Interaction between AQP1, AQP2 and AF might be possible.
    Title: [Expression of antisecretory factor and aquaporin 1, 2 in the rat inner ear and their interaction].
  3. data suggest that antisecretory factor may have a previously unsuspected role in regulating the immune system
    Title: Distribution and immunoregulatory properties of antisecretory factor.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fluid transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome accessory complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
26S proteasome non-ATPase regulatory subunit 4
Names
antisecretory factor
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
proteasome 26S subunit, non-ATPase 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031331.1 → NP_112621.1  26S proteasome non-ATPase regulatory subunit 4

    See identical proteins and their annotated locations for NP_112621.1

    Status: PROVISIONAL

    Source sequence(s)
    AB017188
    UniProtKB/TrEMBL
    A0A8I6A4A3, A6K2U1, F7FEE4, O88321
    Related
    ENSRNOP00000028589.1, ENSRNOT00000028589.5
    Conserved Domains (2) summary
    cd01452
    Location:1 → 187
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    cd22297
    Location:324 → 366
    PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185287941..185297238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232924.5 → XP_006232986.1  26S proteasome non-ATPase regulatory subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006232986.1

    UniProtKB/TrEMBL
    A0A8I6A4A3, Q9ESH1
    Conserved Domains (2) summary
    cd01452
    Location:1 → 187
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    cd22297
    Location:321 → 363
    PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous