bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bambiaprovided by ZNC
Official Full Name: BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010416-1
See related: Ensembl:ENSDARG00000055381 AllianceGenome:ZFIN:ZDB-GENE-010416-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nma; Zfnma; bambi; cb998; fc44c12; id:ibd5020; wu:fc44c12; wu:fe01e03
Summary: Predicted to enable frizzled binding activity. Acts upstream of or within dorsal/ventral pattern formation; negative regulation of BMP signaling pathway; and platelet activation. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; germ ring; optic cup; and pectoral fin bud. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BAMBI (BMP and activin membrane bound inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (23424126..23430352)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (23302907..23309133)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study shows that upregulation of bigh3 and bambia mRNA correlated with the process of fin regeneration and regulation of TGF-b signaling, suggesting a new role for these proteins.
Title: Bigh3 is upregulated in regenerating zebrafish fin.

Submit: New GeneRIF Correction

General gene information

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Markers

AW165100 (e-PCR)
- UniSTS:205882

fc44c12.x1 (e-PCR)
- UniSTS:203922

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a

Names: etID64300.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131784.2 → NP_571859.1 BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a precursor

See identical proteins and their annotated locations for NP_571859.1

Status: PROVISIONAL

Source sequence(s)

AF239925

UniProtKB/TrEMBL

F6PDX7, Q6PCA4, Q9DFZ0

Related

ENSDARP00000072198.4, ENSDART00000077732.5

Conserved Domains (1) summary

pfam06211
Location:1 → 107

BAMBI; BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain