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Rbm5 RNA binding motif protein 5 [ Mus musculus (house mouse) ]

Gene ID: 83486, updated on 25-Apr-2024

Summary

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Official Symbol
Rbm5provided by MGI
Official Full Name
RNA binding motif protein 5provided by MGI
Primary source
MGI:MGI:1933204
See related
Ensembl:ENSMUSG00000032580 AllianceGenome:MGI:1933204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D030069N10Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of apoptotic process; regulation of alternative mRNA splicing, via spliceosome; and spliceosomal complex assembly. Predicted to act upstream of or within RNA splicing; apoptotic process; and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Is expressed in central nervous system; lung; sensory organ; and testis. Orthologous to human RBM5 (RNA binding motif protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 44.1), CNS E11.5 (RPKM 42.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 59.07 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107617694..107648228, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107740495..107771007, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F Neighboring gene STARR-seq mESC enhancer starr_25187 Neighboring gene predicted gene, 51690 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107637781-107637982 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107638598-107638781 Neighboring gene predicted gene, 34605 Neighboring gene STARR-seq mESC enhancer starr_25188 Neighboring gene RNA binding motif protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E6802 Neighboring gene MON1 homolog A, secretory traffciking associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Novel Targets of RBM5 in the Healthy and Injured Brain. Jackson TC, et al. Neuroscience, 2020 Aug 1. PMID 32335213, Free PMC Article
  2. RBM5-AS1 participates in fracture healing and inhibits apoptosis of bone cells through the up-regulation of β-catenin. Huang YZ, et al. Eur Rev Med Pharmacol Sci, 2018 Aug. PMID 30178827
  3. Distinct orientation of the alloreactive monoclonal CD8 T cell activation program by three different peptide/MHC complexes. Auphan-Anezin N, et al. Eur J Immunol, 2006 Jul. PMID 16761314
  4. The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice. Jackson TC, et al. J Cereb Blood Flow Metab, 2015 Mar 31. PMID 25586139, Free PMC Article
  5. RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility. O'Bryan MK, et al. PLoS Genet, 2013. PMID 23935508, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice.
    Title: Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice.
  2. Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease.
    Title: Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease.
  3. RBM5 can inhibit the apoptosis of bone cells by promoting the expression of beta-catenin and can be used as a biomarker for fracture healing.
    Title: RBM5-AS1 participates in fracture healing and inhibits apoptosis of bone cells through the up-regulation of β-catenin.
  4. Expression of Rbm5 and Rbm10 RNA remained constant during C2C12 myogenesis, but protein levels significantly decreased.
    Title: Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels.
  5. The RBM5/10 staining was higher 48 to 72 hours after traumatic brain injury and appeared to be increased in neuronal nuclei of the hippocampus.
    Title: The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice.
  6. Our findings also suggest that the second RRM of RBM5 is pivotal for appropriate pre-mRNA splicing.
    Title: RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Chemically induced (ENU) (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA-binding protein 5
Names
putative tumor suppressor LUCA15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359524.1 → NP_001346453.1  RNA-binding protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC152718
    Consensus CDS
    CCDS90660.1
    Related
    ENSMUSP00000035199.7, ENSMUST00000035199.13
    Conserved Domains (6) summary
    cd12752
    Location:93 → 179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229 → 314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185 → 204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:181 → 210
    zf-RanBP; Zn-finger in Ran binding protein and others
    cd16168
    Location:455 → 509
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam01585
    Location:742 → 786
    G-patch; G-patch domain

  2. NM_001359525.1 → NP_001346454.1  RNA-binding protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC152718
    Consensus CDS
    CCDS23506.1
    UniProtKB/Swiss-Prot
    Q3UZ19, Q91YE7, Q99KV9
    Conserved Domains (6) summary
    cd12752
    Location:93 → 179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229 → 314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185 → 204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:455 → 510
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:183 → 210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:743 → 785
    G-patch; G-patch domain

  3. NM_001359526.1 → NP_001346455.1  RNA-binding protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC152718
    Consensus CDS
    CCDS23506.1
    UniProtKB/Swiss-Prot
    Q3UZ19, Q91YE7, Q99KV9
    Conserved Domains (6) summary
    cd12752
    Location:93 → 179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229 → 314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185 → 204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:455 → 510
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:183 → 210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:743 → 785
    G-patch; G-patch domain

  4. NM_148930.3 → NP_683732.1  RNA-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_683732.1

    Status: VALIDATED

    Source sequence(s)
    AK146880, AW047301, BY140862
    Consensus CDS
    CCDS23506.1
    UniProtKB/Swiss-Prot
    Q3UZ19, Q91YE7, Q99KV9
    Related
    ENSMUSP00000138379.2, ENSMUST00000182659.8
    Conserved Domains (6) summary
    cd12752
    Location:93 → 179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229 → 314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185 → 204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:455 → 510
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:183 → 210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:743 → 785
    G-patch; G-patch domain

RNA

  1. NR_153190.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC152718

  2. NR_153191.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC152718
    Related
    ENSMUST00000182371.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107617694..107648228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511872.3 → XP_006511935.1  RNA-binding protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006511935.1

    UniProtKB/Swiss-Prot
    Q3UZ19, Q91YE7, Q99KV9
    Conserved Domains (6) summary
    cd12752
    Location:93 → 179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229 → 314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185 → 204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:455 → 510
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:183 → 210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:743 → 785
    G-patch; G-patch domain

  2. XM_006511875.3 → XP_006511938.1  RNA-binding protein 5 isoform X4

    See identical proteins and their annotated locations for XP_006511938.1

    Conserved Domains (3) summary
    cd16168
    Location:208 → 263
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam01585
    Location:496 → 538
    G-patch; G-patch domain
    cl17169
    Location:1 → 67
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_030244735.2 → XP_030100595.1  RNA-binding protein 5 isoform X3

    Conserved Domains (5) summary
    cd12755
    Location:57 → 142
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:13 → 32
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:283 → 337
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:11 → 38
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:570 → 612
    G-patch; G-patch domain

  4. XM_030244732.2 → XP_030100592.1  RNA-binding protein 5 isoform X2

    Conserved Domains (5) summary
    cd12755
    Location:57 → 142
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:13 → 32
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:283 → 338
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:11 → 38
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:571 → 613
    G-patch; G-patch domain

  5. XM_030244734.2 → XP_030100594.1  RNA-binding protein 5 isoform X2

    Conserved Domains (5) summary
    cd12755
    Location:57 → 142
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:13 → 32
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:283 → 338
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:11 → 38
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:571 → 613
    G-patch; G-patch domain

  6. XM_030244733.2 → XP_030100593.1  RNA-binding protein 5 isoform X2

    Conserved Domains (5) summary
    cd12755
    Location:57 → 142
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:13 → 32
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:283 → 338
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:11 → 38
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:571 → 613
    G-patch; G-patch domain

  7. XM_006511876.1 → XP_006511939.1  RNA-binding protein 5 isoform X4

    See identical proteins and their annotated locations for XP_006511939.1

    Related
    ENSMUST00000194801.6
    Conserved Domains (3) summary
    cd16168
    Location:208 → 263
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam01585
    Location:496 → 538
    G-patch; G-patch domain
    cl17169
    Location:1 → 67
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_001779079.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YE7.1 GenPept UniProtKB/Swiss-Prot:Q91YE7

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