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Bmp1 bone morphogenetic protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83470, updated on 13-Apr-2024

Summary

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Official Symbol
Bmp1provided by RGD
Official Full Name
bone morphogenetic protein 1provided by RGD
Primary source
RGD:620739
See related
Ensembl:ENSRNOG00000010890 AllianceGenome:RGD:620739
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within positive regulation of cartilage development. Located in extracellular space and vesicle. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 13. Orthologous to human BMP1 (bone morphogenetic protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 243.1), Liver (RPKM 137.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51961310..52005597, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45551603..45595862, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52166401..52210786, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene microRNA 320a Neighboring gene uncharacterized LOC120097030 Neighboring gene phytanoyl-CoA 2-hydroxylase interacting protein Neighboring gene uncharacterized LOC134482143 Neighboring gene surfactant protein C Neighboring gene leucine-rich repeat LGI family, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A regulatory role of androgen in ovarian steroidogenesis by rat granulosa cells. Hasegawa T, et al. J Steroid Biochem Mol Biol, 2017 Sep. PMID 28684382
  2. Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid. Berry R, et al. Proc Natl Acad Sci U S A, 2009 May 26. PMID 19429706, Free PMC Article
  3. Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin. Zhang Y, et al. J Biol Chem, 2006 Dec 22. PMID 17071617
  4. bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Jasuja R, et al. Mech Dev, 2006 Jul. PMID 16824737
  5. Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis. Grgurevic L, et al. J Am Soc Nephrol, 2011 Apr. PMID 21415150, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Collectively, the results indicate that androgen and IGF-I mutually interact and accelerate progesterone production, at least in part, by regulating endogenous BMP signaling in rat granulosa cells.
    Title: A regulatory role of androgen in ovarian steroidogenesis by rat granulosa cells.
  2. Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.
    Title: Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.
  3. bone morphogenetic protein 1 is inhibited by native and altered forms of alpha2-macroglobulin
    Title: Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cartilage development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bone morphogenetic protein 1
Names
procollagen C-proteinase
NP_112613.1
XP_006252347.1
XP_038949617.1
XP_038949618.1
XP_063130764.1
XP_063130765.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031323.1 → NP_112613.1  bone morphogenetic protein 1 precursor

    See identical proteins and their annotated locations for NP_112613.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6HTK6, F1M798
    Related
    ENSRNOP00000040287.4, ENSRNOT00000046054.5
    Conserved Domains (4) summary
    cd04281
    Location:125 → 324
    ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
    pfam00431
    Location:439 → 548
    CUB; CUB domain
    pfam01400
    Location:132 → 325
    Astacin; Astacin (Peptidase family M12A)
    pfam14670
    Location:711 → 746
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    51961310..52005597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093690.2 → XP_038949618.1  bone morphogenetic protein 1 isoform X3

    UniProtKB/TrEMBL
    A6HTK7
    Conserved Domains (3) summary
    pfam00431
    Location:205 → 314
    CUB; CUB domain
    pfam14670
    Location:325 → 357
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00064
    Location:13 → 90
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

  2. XM_006252285.3 → XP_006252347.1  bone morphogenetic protein 1 isoform X2

    UniProtKB/TrEMBL
    A6HTK7
    Conserved Domains (3) summary
    pfam00431
    Location:277 → 386
    CUB; CUB domain
    pfam14670
    Location:397 → 429
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00064
    Location:24 → 162
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

  3. XM_039093689.2 → XP_038949617.1  bone morphogenetic protein 1 isoform X1

    Conserved Domains (3) summary
    cd04281
    Location:125 → 324
    ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
    pfam00431
    Location:439 → 548
    CUB; CUB domain
    pfam14670
    Location:559 → 591
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  4. XM_063274694.1 → XP_063130764.1  bone morphogenetic protein 1 isoform X4

  5. XM_063274695.1 → XP_063130765.1  bone morphogenetic protein 1 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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