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Celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83465, updated on 30-Mar-2024

Summary

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Official Symbol
Celsr2provided by RGD
Official Full Name
cadherin, EGF LAG seven-pass G-type receptor 2provided by RGD
Primary source
RGD:69237
See related
Ensembl:ENSRNOG00000020058 AllianceGenome:RGD:69237
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Megf3
Summary
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in dendrite morphogenesis; regulation of cell-cell adhesion; and spermatogenesis. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 129.6), Brain (RPKM 79.5) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198717333..198741689, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (196029206..196053848, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (211183410..211207458, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene myosin binding protein H-like Neighboring gene uncharacterized LOC134485672 Neighboring gene proline and serine rich coiled-coil 1 Neighboring gene uncharacterized LOC108350091 Neighboring gene seryl-tRNA synthetase 1 Neighboring gene small nucleolar RNA SNORA70

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Silencing Celsr2 inhibits the proliferation and migration of Schwann cells through suppressing the Wnt/β-catenin signaling pathway. Zhou X, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 32988580
  2. Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1. Lahousse SA, et al. Toxicol Sci, 2006 May. PMID 16484285
  3. Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity. Beall SA, et al. J Androl, 2005 Jul-Aug. PMID 15955893
  4. Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Shima Y, et al. Dev Cell, 2004 Aug. PMID 15296717
  5. Opposing roles in neurite growth control by two seven-pass transmembrane cadherins. Shima Y, et al. Nat Neurosci, 2007 Aug. PMID 17618280

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing Celsr2 inhibits the proliferation and migration of Schwann cells through suppressing the Wnt/beta-catenin signaling pathway.
    Title: Silencing Celsr2 inhibits the proliferation and migration of Schwann cells through suppressing the Wnt/β-catenin signaling pathway.
  2. The Celsr2 enhanced neurite growth of neuron in hippocampus of rat.
    Title: Opposing roles in neurite growth control by two seven-pass transmembrane cadherins.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebrospinal fluid secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebrospinal fluid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in motor neuron migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within motor neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in neural plate anterior/posterior regionalization IEA
Inferred from Electronic Annotation
more info
  
involved_in neural plate anterior/posterior regionalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in ventricular system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ventricular system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cadherin EGF LAG seven-pass G-type receptor 2
Names
Flamingo1
cadherin EGF LAG seven-pas G-type receptor 2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
flamingo-like protein celsr2
multiple EGF-like domains protein 3
multiple epidermal growth factor-like domains 3
multiple epidermal growth factor-like domains protein 3
seven-pass transmembrane cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191110.1 → NP_001178039.1  cadherin EGF LAG seven-pass G-type receptor 2 precursor

    See identical proteins and their annotated locations for NP_001178039.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HV01, G3V8P3
    Conserved Domains (10) summary
    smart00303
    Location:2315 → 2368
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:404 → 501
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:1972 → 2034
    HormR; Domain present in hormone receptors
    smart00180
    Location:1924 → 1969
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00054
    Location:1289 → 1324
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1369 → 1552
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01500
    Location:1806 → 1956
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam16489
    Location:2052 → 2287
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl19567
    Location:1819 → 1866
    DSL; Delta serrate ligand
    cl21561
    Location:2374 → 2605
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    198717333..198741689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103241.2 → XP_038959169.1  cadherin EGF LAG seven-pass G-type receptor 2 isoform X3

    UniProtKB/TrEMBL
    G3V8P3

  2. XM_006233192.5 → XP_006233254.1  cadherin EGF LAG seven-pass G-type receptor 2 isoform X1

    UniProtKB/TrEMBL
    G3V8P3
    Related
    ENSRNOP00000027263.6
    Conserved Domains (10) summary
    smart00303
    Location:2315 → 2368
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:404 → 501
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:1972 → 2034
    HormR; Domain present in hormone receptors
    smart00180
    Location:1924 → 1969
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00054
    Location:1289 → 1324
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1369 → 1552
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01500
    Location:1806 → 1956
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam16489
    Location:2052 → 2287
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl19567
    Location:1819 → 1866
    DSL; Delta serrate ligand
    cl21561
    Location:2374 → 2605
    7tm_4; Olfactory receptor

  3. XM_017591134.3 → XP_017446623.1  cadherin EGF LAG seven-pass G-type receptor 2 isoform X2

    UniProtKB/TrEMBL
    G3V8P3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031319.1: Suppressed sequence

    Description
    NM_031319.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYP2.1 GenPept UniProtKB/Swiss-Prot:Q9QYP2

Gene LinkOut

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