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FZD1 frizzled class receptor 1 [ Homo sapiens (human) ]

Gene ID: 8321, updated on 4-Jan-2025

Summary

Official Symbol
FZD1provided by HGNC
Official Full Name
frizzled class receptor 1provided by HGNC
Primary source
HGNC:HGNC:4038
See related
Ensembl:ENSG00000157240 MIM:603408; AllianceGenome:HGNC:4038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See FZD1 in Genome Data Viewer
Location:
7q21.13
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (91264433..91271326)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (92512278..92519169)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (90893748..90900641)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 14 Neighboring gene uncharacterized LOC124901694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:90661021-90661555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:90690954-90691454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:90691455-90691955 Neighboring gene VISTA enhancer hs1627 Neighboring gene VISTA enhancer hs1628 Neighboring gene VISTA enhancer hs1633 Neighboring gene PTP4A1 pseudogene 3 Neighboring gene VISTA enhancer hs1631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18364 Neighboring gene uncharacterized LOC124901695 Neighboring gene heart enhancer 20 Neighboring gene long intergenic non-protein coding RNA 2932 Neighboring gene NIPA2 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The expression of frizzled class receptor 1 (FZD1) gene is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ95923, DKFZp564G072

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity  
enables PDZ domain binding PubMed 
enables Wnt receptor activity  
enables Wnt receptor activity PubMed 
enables Wnt receptor activity PubMed 
enables Wnt receptor activity PubMed 
enables Wnt-protein binding  
enables Wnt-protein binding PubMed 
enables Wnt-protein binding PubMed 
enables frizzled binding PubMed 
enables protein binding PubMed 
enables signaling receptor binding PubMed 
Items 1 - 25 of 29
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway  
involved_in astrocyte-dopaminergic neuron signaling  
involved_in autocrine signaling PubMed 
involved_in canonical Wnt signaling pathway  
involved_in canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway PubMed 
involved_in cell-cell signaling PubMed 
involved_in endothelial cell differentiation  
involved_in hard palate development  
involved_in membranous septum morphogenesis  
involved_in midbrain dopaminergic neuron differentiation PubMed 
involved_in muscular septum morphogenesis  
involved_in negative regulation of BMP signaling pathway  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of canonical Wnt signaling pathway  
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
involved_in neuron differentiation  
involved_in non-canonical Wnt signaling pathway  
involved_in outflow tract morphogenesis  
involved_in positive regulation of DNA-binding transcription factor activity PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of neuron projection development  
involved_in positive regulation of osteoblast differentiation PubMed 
involved_in presynapse assembly PubMed 
involved_in regulation of mesenchymal stem cell differentiation PubMed 
involved_in regulation of presynapse assembly  
involved_in response to xenobiotic stimulus PubMed 
Items 1 - 25 of 29
Component Evidence Code Pubs
part_of Wnt signalosome PubMed 
located_in cell surface PubMed 
located_in focal adhesion PubMed 
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
frizzled-1
Names
Wnt receptor
frizzled 1, seven transmembrane spanning receptor
frizzled family receptor 1
frizzled homolog 1
frizzled, Drosophila, homolog of, 1
fz-1
fzE1
hFz1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003505.2NP_003496.1  frizzled-1

    See identical proteins and their annotated locations for NP_003496.1

    Status: REVIEWED

    Source sequence(s)
    AB017363, AC084381
    Consensus CDS
    CCDS5620.1
    UniProtKB/Swiss-Prot
    A4D1E8, O94815, Q549T8, Q9UP38
    UniProtKB/TrEMBL
    B2RC95
    Related
    ENSP00000287934.2, ENST00000287934.4
    Conserved Domains (2) summary
    cd07465
    Location:112238
    CRD_FZ1; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 1 (Fz1) receptor
    pfam01534
    Location:310634
    Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    91264433..91271326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    92512278..92519169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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