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FLS1 flavonol synthase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830765, updated on 14-Feb-2024

Summary

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Gene symbol
FLS1
Gene description
flavonol synthase 1
Primary source
Araport:AT5G08640
Locus tag
AT5G08640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATFLS1; FLAVONOL SYNTHASE; flavonol synthase 1; FLS; T2K12.5
Summary
Encodes a flavonol synthase that catalyzes formation of flavonols from dihydroflavonols. Co-expressed with CHI and CHS (qRT-PCR).
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Genomic context

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Location:
chromosome: 5
Exon count:
4
Sequence:
Chromosome: 5; NC_003076.8 (2803833..2805606)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DEA(D/H)-box RNA helicase family protein Neighboring gene DDT domain-containing protein Neighboring gene Small GTP-binding protein Neighboring gene D-lactate dehydrogenase (DUF668) Neighboring gene ATP synthase alpha/beta family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Arabidopsis thaliana FLAVONOL SYNTHASE 1 (FLS1) -overexpression plants in response to abiotic stress. Nguyen NH, et al. Plant Physiol Biochem, 2016 Jun. PMID 26990404
  2. In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana. Prescott AG, et al. Phytochemistry, 2002 Jul. PMID 12126705
  3. Drastic anthocyanin increase in response to PAP1 overexpression in fls1 knockout mutant confers enhanced osmotic stress tolerance in Arabidopsis thaliana. Lee WJ, et al. Plant Cell Rep, 2016 Nov. PMID 27562381
  4. Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana. Chapman JM, et al. J Biol Chem, 2021 Jan-Jun. PMID 33839683, Free PMC Article
  5. Förster resonance energy transfer demonstrates a flavonoid metabolon in living plant cells that displays competitive interactions between enzymes. Crosby KC, et al. FEBS Lett, 2011 Jul 21. PMID 21669202

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives.
    Title: Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives.
  2. Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana.
    Title: Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana.
  3. double mutant plants that harbor fls1kknock out in the pap1-D background (i.e., pap1-D/fls1ko plants) were generated, to examine whether anthocyanins can be further enhanced by blocking flavonol biosynthesis under PAP1 overexpression.
    Title: Drastic anthocyanin increase in response to PAP1 overexpression in fls1 knockout mutant confers enhanced osmotic stress tolerance in Arabidopsis thaliana.
  4. Overexpression of FLS1 (FLS1-OX) not only altered seed coat color (resulting in a light brown color), but also affected flavonoid accumulation. Whereas fls1-3 mutants accumulated higher anthocyanin levels, FLS1-OX seedlings had lower levels than those of the wild-type.
    Title: Characterization of Arabidopsis thaliana FLAVONOL SYNTHASE 1 (FLS1) -overexpression plants in response to abiotic stress.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001203337.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables flavonol synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables naringenin 3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within flavonoid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to auxin IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
flavonol synthase 1
NP_001190266.1
  • flavonol synthase 1 (FLS1); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: flavonol synthase 3 (TAIR:AT5G63590.1).
NP_196481.1
  • flavonol synthase 1 (FLS1); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: flavonol synthase 3 (TAIR:AT5G63590.1); Has 8476 Blast hits to 8432 proteins in 992 species: Archae - 0; Bacteria - 1104; Metazoa - 92; Fungi - 925; Plants - 4948; Viruses - 0; Other Eukaryotes - 1407 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    2803833..2805606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120951.3 → NP_196481.1  flavonol synthase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196481.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04730, O04731, O04732, O04830, O04831, O04832, Q96330
    UniProtKB/TrEMBL
    A0A178UE53, A0A384L0E6, B1GV57, B1GV59, B7SFQ1
    Conserved Domains (1) summary
    PLN02704
    Location:1 → 335
    PLN02704; flavonol synthase

  2. NM_001203337.1 → NP_001190266.1  flavonol synthase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190266.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04730, O04731, O04732, O04830, O04831, O04832, Q96330
    UniProtKB/TrEMBL
    A0A178UE53, A0A384L0E6, B1GV57, B1GV59, B7SFQ1
    Conserved Domains (1) summary
    PLN02704
    Location:1 → 335
    PLN02704; flavonol synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96330.1

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