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F3H flavanone 3-hydroxylase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824287, updated on 14-Feb-2024

Summary

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Gene symbol
F3H
Gene description
flavanone 3-hydroxylase
Primary source
Araport:AT3G51240
Locus tag
AT3G51240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F3'H; flavanone 3-hydroxylase; FLAVANONE 3-HYDROXYLASE; TRANSPARENT TESTA 6; TT6
Summary
Encodes flavanone 3-hydroxylase that is coordinately expressed with chalcone synthase and chalcone isomerases. Regulates flavonoid biosynthesis. Not responsive to auxin or ethylene stimulus (qRT-PCR).
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Genomic context

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Location:
chromosome: 3
Exon count:
3
Sequence:
Chromosome: 3; NC_003074.8 (19025192..19026872)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene WEB family protein (DUF827) Neighboring gene chalcone-flavanone isomerase family protein Neighboring gene ncRNA Neighboring gene Senescence/dehydration-associated protein-like protein Neighboring gene 20S proteasome alpha subunit PAD1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemical and genetic characterization of Arabidopsis flavanone 3beta-hydroxylase. Owens DK, et al. Plant Physiol Biochem, 2008 Oct. PMID 18657430
  2. Knock-out mutants from an En-1 mutagenized Arabidopsis thaliana population generate phenylpropanoid biosynthesis phenotypes. Wisman E, et al. Proc Natl Acad Sci U S A, 1998 Oct 13. PMID 9770503, Free PMC Article
  3. Analysis of flavanone 3-hydroxylase in Arabidopsis seedlings. Coordinate regulation with chalcone synthase and chalcone isomerase. Pelletier MK, et al. Plant Physiol, 1996 May. PMID 8685272, Free PMC Article
  4. Arabidopsis Flavonoid Mutants Are Hypersensitive to UV-B Irradiation. Li J, et al. Plant Cell, 1993 Feb. PMID 12271060, Free PMC Article
  5. Interactions among enzymes of the Arabidopsis flavonoid biosynthetic pathway. Burbulis IE, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10536025, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives.
    Title: Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives.
  2. experiments indicate that the absence of F3H in these lines enables the synthesis of uncommon 3-deoxy flavonoids in the Arabidopsis seed coat
    Title: Biochemical and genetic characterization of Arabidopsis flavanone 3beta-hydroxylase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001203121.1
NM_114983.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables naringenin 3-dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables naringenin 3-dioxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within flavonoid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in flavonoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within flavonoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within flavonoid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within response to UV-B IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
flavanone 3-hydroxylase
NP_001190050.1
  • flavanone 3-hydroxylase (F3H); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (TAIR:AT4G10490.1).
NP_190692.1
  • flavanone 3-hydroxylase (F3H); FUNCTIONS IN: naringenin 3-dioxygenase activity; INVOLVED IN: response to UV-B, response to sucrose stimulus, flavonoid biosynthetic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (TAIR:AT4G10500.1); Has 8311 Blast hits to 8276 proteins in 982 species: Archae - 0; Bacteria - 1082; Metazoa - 105; Fungi - 917; Plants - 4933; Viruses - 0; Other Eukaryotes - 1274 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    19025192..19026872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_114983.3 → NP_190692.1  flavanone 3-hydroxylase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190692.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q38877, Q9C526, Q9C528, Q9C530, Q9C563, Q9C5V7, Q9S818
    UniProtKB/TrEMBL
    A0A5S9XJS4, Q5DWW0
    Conserved Domains (1) summary
    PLN02515
    Location:1 → 358
    PLN02515; naringenin,2-oxoglutarate 3-dioxygenase

  2. NM_001203121.1 → NP_001190050.1  flavanone 3-hydroxylase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190050.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4J3A5
    Conserved Domains (3) summary
    PLN02515
    Location:1 → 274
    PLN02515; naringenin,2-oxoglutarate 3-dioxygenase
    pfam03171
    Location:110 → 210
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
    cl21672
    Location:1 → 36
    DIOX_N; non-haem dioxygenase in morphine synthesis N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9S818.1

Gene LinkOut

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