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ALDH10A9 aldehyde dehydrogenase 10A9 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 823972, updated on 7-Sep-2023

Summary

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Gene symbol
ALDH10A9
Gene description
aldehyde dehydrogenase 10A9
Primary source
Araport:AT3G48170
Locus tag
AT3G48170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
aldehyde dehydrogenase 10A9; BADH; BETAINE ALDEHYDE DEHYDROGENASE
Summary
ALDH10A9 encodes a protein that can function as a betaine aldehyde dehydrogenase in vitro. The C-terminal amino acids of this protein direct GFP to the peroxisome suggesting that ALDH10A9 accumulates in this organelle. ALDH10A9 transcript levels rise in response to ABA, NaCl, chilling, methyl viologen, and dehydration stress. The enzyme can catalyze the formation of glycine betaine in vitro, but there are still questions about whether Arabidopsis makes this protective compound under natural conditions. This enzyme may be involved in oxidizing aminoaldehydes formed through polyamine metabolism.
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Genomic context

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Location:
chromosome: 3
Exon count:
15
Sequence:
Chromosome: 3; NC_003074.8 (17785854..17790026, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene B12D protein Neighboring gene anaphase-promoting complex subunit 8 Neighboring gene DP-E2F-like 1 Neighboring gene CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Roles for ALDH10 enzymes in γ-butyrobetaine synthesis, seed development, germination, and salt tolerance in Arabidopsis. Jacques F, et al. J Exp Bot, 2020 Dec 31. PMID 32845293
  2. Arabidopsis aldehyde dehydrogenase 10 family members confer salt tolerance through putrescine-derived 4-aminobutyrate (GABA) production. Zarei A, et al. Sci Rep, 2016 Oct 11. PMID 27725774, Free PMC Article
  3. Overexpression of ALDH10A8 and ALDH10A9 Genes Provides Insight into Their Role in Glycine Betaine Synthesis and Affects Primary Metabolism in Arabidopsis thaliana. Missihoun TD, et al. Plant Cell Physiol, 2015 Sep. PMID 26169197
  4. Betaine aldehyde dehydrogenase genes from Arabidopsis with different sub-cellular localization affect stress responses. Missihoun TD, et al. Planta, 2011 Feb. PMID 21053011
  5. Proteome analysis of peroxisomes from etiolated Arabidopsis seedlings identifies a peroxisomal protease involved in β-oxidation and development. Quan S, et al. Plant Physiol, 2013 Dec. PMID 24130194, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The pH optima for activity and catalytic efficiency of recombinant AtALDH10A8 with 3-aminopropanal as substrate was 10.5 and 8.5, respectively, whereas the optima for AtALDH10A9 were approximately 9.5.
    Title: Arabidopsis aldehyde dehydrogenase 10 family members confer salt tolerance through putrescine-derived 4-aminobutyrate (GABA) production.
  2. ALDH10A8 and ALDH10A9 are involved in the synthesis of glycine betaine in Arabidopsis.
    Title: Overexpression of ALDH10A8 and ALDH10A9 Genes Provides Insight into Their Role in Glycine Betaine Synthesis and Affects Primary Metabolism in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_114686.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminobutyraldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables betaine-aldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables gamma-guanidinobutyraldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular detoxification of aldehyde IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycine betaine biosynthetic process from choline IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycine betaine biosynthetic process from choline IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in peroxisome HDA PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aldehyde dehydrogenase 10A9
NP_190400.1
  • aldehyde dehydrogenase 10A9 (ALDH10A9); FUNCTIONS IN: 3-chloroallyl aldehyde dehydrogenase activity, oxidoreductase activity; INVOLVED IN: oxidation reduction, glycine betaine biosynthetic process from choline, metabolic process; LOCATED IN: peroxisome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Aldehyde dehydrogenase (InterPro:IPR015590), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Aldehyde dehydrogenase, conserved site (InterPro:IPR016160); BEST Arabidopsis thaliana protein match is: aldehyde dehydrogenase 10A8 (TAIR:AT1G74920.1); Has 62829 Blast hits to 62511 proteins in 3057 species: Archae - 483; Bacteria - 36293; Metazoa - 2617; Fungi - 2126; Plants - 2053; Viruses - 0; Other Eukaryotes - 19257 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    17785854..17790026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_114686.4 → NP_190400.1  aldehyde dehydrogenase 10A9 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190400.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q42237, Q9STS1
    UniProtKB/TrEMBL
    A0A178VGM7, A0A5S9XKJ6
    Conserved Domains (1) summary
    PLN02467
    Location:1 → 503
    PLN02467; betaine aldehyde dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9STS1.1

Gene LinkOut

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