Sctr secretin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sctrprovided by RGD
Official Full Name: secretin receptorprovided by RGD
Primary source: RGD:621342
See related: Ensembl:ENSRNOG00000049766 AllianceGenome:RGD:621342
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables peptide binding activity and secretin receptor activity. Involved in brain development and positive regulation of cAMP-mediated signaling. Predicted to be located in cytoplasmic microtubule. Predicted to be active in plasma membrane. Orthologous to human SCTR (secretin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 66.8), Spleen (RPKM 27.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (33680562..33744049)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (31127781..31190162)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (36039241..36090515)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.
Title: Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.
Secretin receptors are overexpressed in various endocrine tumor cells and play a proproliferative role in pheochromocytoma and adrenocortical carcinoma cells.
Title: Secretin receptor promotes the proliferation of endocrine tumor cells via the PI3K/AKT pathway.
Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.
Title: Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.
Data show that in secretin/secretin receptor binding, the alpha-helix in natural secretin was oriented approximately parallel to the amino-terminal alpha-helix of the receptor.
Title: Importance of each residue within secretin for receptor binding and biological activity.
Model of helical bundle and loop domains of prototypic secretin receptor is consistent with endogenous agonist mechanism for class II G-protein-coupled receptor activation, where ligand binding promotes interaction of a portion of receptor amino terminus.
Title: Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding.
refined model of the intact receptor was also fully consistent with the spatial approximation of the Trp(48)-Asp(49)-Asn(50) endogenous agonist segment with the third extracellular loop region that it has been shown to photolabel
Title: Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues.
This recepetor interacts with secretin at specific binding sites.
Title: Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus.
analysis of the pattern of disulfide bonds in the functional intact secretin receptor
Title: Paired cysteine mutagenesis to establish the pattern of disulfide bonds in the functional intact secretin receptor.
There is a charge-charge interaction between glutamic acid residue at position 351 and amino terminus that is critical to secretin normal docking.
Title: Insights into the structure and molecular basis of ligand docking to the G protein-coupled secretin receptor using charge-modified amino-terminal agonist probes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables secretin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables secretin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables secretin receptor activity	IEA Inferred from Electronic Annotation more info
enables secretin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in diet induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular water homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cAMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal water absorption	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasmic microtubule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secretin receptor

Names: SCT-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031115.1 → NP_112377.1 secretin receptor precursor

See identical proteins and their annotated locations for NP_112377.1

Status: PROVISIONAL

Source sequence(s)

X59132

UniProtKB/Swiss-Prot

P23811

UniProtKB/TrEMBL

M0R5B5

Related

ENSRNOP00000092013.1, ENSRNOT00000119589.1

Conserved Domains (2) summary

smart00008
Location:62 → 132

HormR; Domain present in hormone receptors

pfam00002
Location:139 → 384

7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

33680562..33744049

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091119.2 → XP_038947047.1 secretin receptor isoform X4

UniProtKB/TrEMBL

M0R5B5

Conserved Domains (2) summary

smart00008
Location:80 → 147

HormR; Domain present in hormone receptors

cd15275
Location:154 → 409

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
XM_039091116.2 → XP_038947044.1 secretin receptor isoform X2

UniProtKB/TrEMBL

M0R5B5

Conserved Domains (2) summary

smart00008
Location:80 → 147

HormR; Domain present in hormone receptors

cd15275
Location:154 → 418

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
XM_039091115.2 → XP_038947043.1 secretin receptor isoform X1

UniProtKB/TrEMBL

A0A8I5YBX3, M0R5B5

Related

ENSRNOP00000077594.1

Conserved Domains (2) summary

smart00008
Location:80 → 147

HormR; Domain present in hormone receptors

cd15275
Location:154 → 420

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
XM_039091118.2 → XP_038947046.1 secretin receptor isoform X3

UniProtKB/TrEMBL

M0R5B5

Conserved Domains (2) summary

smart00008
Location:62 → 132

HormR; Domain present in hormone receptors

cd15275
Location:139 → 403

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
XM_039091120.2 → XP_038947048.1 secretin receptor isoform X5

UniProtKB/TrEMBL

M0R5B5

Conserved Domains (2) summary

cd15275
Location:103 → 369

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

cl02422
Location:64 → 90

HRM; Hormone receptor domain