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Rbl2 RB transcriptional corepressor like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81758, updated on 13-Apr-2024

Summary

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Official Symbol
Rbl2provided by RGD
Official Full Name
RB transcriptional corepressor like 2provided by RGD
Primary source
RGD:3541
See related
Ensembl:ENSRNOG00000012153 AllianceGenome:RGD:3541
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rb2
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of G1/S transition of mitotic cell cycle; and regulation of lipid kinase activity. Predicted to act upstream of or within negative regulation of gene expression. Located in chromatin. Orthologous to human RBL2 (RB transcriptional corepressor like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 174.5), Kidney (RPKM 140.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbl2 in Genome Data Viewer
Location:
19p11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (32049690..32096467, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (15876852..15923632, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (17300088..17346865, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Rpgrip1-like Neighboring gene uncharacterized LOC134483615 Neighboring gene AKT interacting protein Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene chromodomain helicase DNA binding protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes. Galderisi U, et al. Stem Cells Dev, 2009 Sep. PMID 19099372
  2. Role of RB and RB2/P130 genes in marrow stromal stem cells plasticity. Jori FP, et al. J Cell Physiol, 2004 Aug. PMID 15174090
  3. Cloning and characterization of the rat p130, a member of the retinoblastoma gene family. Sawada Y, et al. Biochim Biophys Acta, 1997 Jul 10. PMID 9247086
  4. Cooperation between p53 and p130(Rb2) in induction of cellular senescence. Kapić A, et al. Cell Death Differ, 2006 Feb. PMID 16123778
  5. RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells. Jori FP, et al. Cell Death Differ, 2005 Jan. PMID 15459751

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RB2/P130 could be a marker of senescence or that it even plays a role in triggering the process in MSCs.
    Title: In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes.
  2. PPARalpha trans-repression involved the recruitment of the retinoblastoma (RB) family proteins p107 and p130 to the TERT promoter resulting in impaired E2F-1 binding, an effect that was dependent on p16.
    Title: The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation.
  3. Rb2 was found to have a role in neural differentiation but not in neural determination.
    Title: Role of RB and RB2/P130 genes in marrow stromal stem cells plasticity.
  4. p130-E2F4 complex recruits the chromatin modifiers HDAC1 and Suv39H1 to promote gene silencing and neuron survival.
    Title: Regulation of neuron survival and death by p130 and associated chromatin modifiers.
  5. data indicate that p53 can cooperate selectively with p130(Rb2) to induce cellular senescence, a pathway that may be relevant when the pRb/p16INK4a pathway is defunct
    Title: Cooperation between p53 and p130(Rb2) in induction of cellular senescence.
  6. RB2/p130 plays a role in the early neural differentiation of mysenchymal stem cells through histone deacetylases dependent pathways.
    Title: RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables promoter-specific chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
retinoblastoma-like protein 2
Names
130 kDa retinoblastoma-associated protein
P130
PPAR-alpha-interacting complex protein 128
PRB2
PRIC128
RBR-2
retinoblastoma-like 2
retinoblastoma-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031094.2 → NP_112356.2  retinoblastoma-like protein 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    O55081
    UniProtKB/TrEMBL
    A6KD82
    Related
    ENSRNOP00000088993.1, ENSRNOT00000117469.1
    Conserved Domains (5) summary
    pfam01858
    Location:414 → 606
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:101 → 233
    DUF3452; Domain of unknown function (DUF3452)
    cd00043
    Location:41 → 131
    CYCLIN_SF; Cyclin box fold superfamily
    cd20606
    Location:831 → 1018
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:696 → 834
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    32049690..32096467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255199.5 → XP_006255261.1  retinoblastoma-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O55081
    UniProtKB/TrEMBL
    G3V7P7
    Related
    ENSRNOP00000017361.3
    Conserved Domains (4) summary
    pfam01857
    Location:831 → 1011
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:414 → 606
    RB_A; Retinoblastoma-associated protein A domain
    pfam04518
    Location:323 → 433
    Effector_1; Effector from type III secretion system
    pfam11934
    Location:101 → 233
    DUF3452; Domain of unknown function (DUF3452)

  2. XM_006255200.5 → XP_006255262.1  retinoblastoma-like protein 2 isoform X2

    UniProtKB/Swiss-Prot
    O55081
    Conserved Domains (4) summary
    pfam01857
    Location:831 → 921
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:414 → 606
    RB_A; Retinoblastoma-associated protein A domain
    pfam04518
    Location:323 → 433
    Effector_1; Effector from type III secretion system
    pfam11934
    Location:101 → 233
    DUF3452; Domain of unknown function (DUF3452)

  3. XM_063278309.1 → XP_063134379.1  retinoblastoma-like protein 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55081.1 GenPept UniProtKB/Swiss-Prot:O55081

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