Pth2r parathyroid hormone 2 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pth2rprovided by RGD
Official Full Name: parathyroid hormone 2 receptorprovided by RGD
Primary source: RGD:620612
See related: Ensembl:ENSRNOG00000015259 AllianceGenome:RGD:620612
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pthr2
Summary: Enables parathyroid hormone receptor activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and positive regulation of cold-induced thermogenesis. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human PTH2R (parathyroid hormone 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 5.2) and Adrenal (RPKM 1.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (74199785..74304326)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (66706050..66810601)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (72052966..72158343)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

specific interactions within the ligand-receptor bimolecular complex mediate distinct postactivation responses of class II G protein- coupled receptors and provide novel insights into the physiological regulation of PTH2R activity
Title: Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.
results suggest that an inhibition of endogenous nitric oxide production unmasks a profound negative inotropic effect of tuberoinfundibular peptide (TIP39) that is mediated by an activation of the parathyroid hormone receptor 2
Title: Tuberoinfundibular peptide of 39 residues: a new mediator of cardiac function via nitric oxide production in the rat heart.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables parathyroid hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables parathyroid hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: parathyroid hormone 2 receptor

Names: PTH2 receptor; parathyroid hormone receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031089.3 → NP_112351.2 parathyroid hormone 2 receptor precursor

Status: REVIEWED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P70555

UniProtKB/TrEMBL

A6IPK1, G3V800

Related

ENSRNOP00000021099.1, ENSRNOT00000021099.3

Conserved Domains (3) summary

smart00008
Location:60 → 133

HormR; Domain present in hormone receptors

cd14964
Location:141 → 166

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:139 → 427

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily