Ctbp2 C-terminal binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctbp2provided by RGD
Official Full Name: C-terminal binding protein 2provided by RGD
Primary source: RGD:68372
See related: Ensembl:ENSRNOG00000017326 AllianceGenome:RGD:68372
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including identical protein binding activity; retinoic acid receptor binding activity; and transcription corepressor binding activity. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in negative regulation of transcription, DNA-templated; synaptic vesicle docking; and white fat cell differentiation. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of chromatin binding activity; and positive regulation of retinoic acid receptor signaling pathway. Predicted to be located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and ribbon synapse. Predicted to be part of transcription repressor complex. Predicted to be active in photoreceptor ribbon synapse; presynaptic active zone cytoplasmic component; and presynaptic cytosol. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 135.0), Kidney (RPKM 116.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (197208536..197348802, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (187782064..187918115, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (205001354..205030565, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dorsal hippocampal CA3 regulates spatial reference memory through the CtBP2/GluR2 pathway.
Title: The dorsal hippocampal CA3 regulates spatial reference memory through the CtBP2/GluR2 pathway.
esults indicated that Brn4 promoted the neuronal differentiation of neural stem cells via inhibition of CtBP2 and is a potential tool for generating neurons in cell replacement therapy of neurodegenerative diseases and brain injury
Title: Brn4 promotes the differentiation of radial glial cells into neurons by inhibiting CtBP2.
Microenvironmental oxygen levels influence the dimerization and acetylation levels, and thereby the activity, of CtBP2 in proliferating neural stem cells.
Title: Oxygen-dependent acetylation and dimerization of the corepressor CtBP2 in neural stem cells.
CtBP2 was expressed in normal sciatic nerve. It gradually decreased, reached minimal levels at 7 days after crush, & returned to normal at 4 weeks. It is expressed in Schwann cells & is downregulated during differentiation. It upregulates p75NTR.
Title: The role of C-terminal binding protein 2 in Schwann cell differentiation after sciatic nerve crush.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130239 (e-PCR)
- UniSTS:213526

RH144529 (e-PCR)
- UniSTS:233774

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of presynaptic active zone	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in maintenance of presynaptic active zone structure	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle docking	ISO Inferred from Sequence Orthology more info
involved_in white fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in white fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in photoreceptor ribbon synapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone cytoplasmic component	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in ribbon synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: C-terminal-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053335.2 → NP_445787.1 C-terminal-binding protein 2

See identical proteins and their annotated locations for NP_445787.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6HX13

Related

ENSRNOP00000023404.3, ENSRNOT00000023404.7

Conserved Domains (2) summary

COG0111
Location:593 → 903

SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:577 → 895

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

197208536..197348802 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275206.1 → XP_063131276.1 C-terminal-binding protein 2 isoform X5
XM_063275168.1 → XP_063131238.1 C-terminal-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q9EQH5

UniProtKB/TrEMBL

A6HX12
XM_063275150.1 → XP_063131220.1 C-terminal-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q9EQH5

UniProtKB/TrEMBL

A6HX12
XM_039092148.2 → XP_038948076.1 C-terminal-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q9EQH5

UniProtKB/TrEMBL

A0A8I6AEI5, A6HX12

Related

ENSRNOP00000090411.1

Conserved Domains (1) summary

cd05299
Location:34 → 352

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_039092175.2 → XP_038948103.1 C-terminal-binding protein 2 isoform X4

UniProtKB/TrEMBL

A0A8I6AEI5

Conserved Domains (1) summary

cd05299
Location:9 → 327

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_039092153.2 → XP_038948081.1 C-terminal-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q9EQH5

UniProtKB/TrEMBL

A0A8I6AEI5, A6HX12

Conserved Domains (1) summary

cd05299
Location:34 → 352

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_039092159.2 → XP_038948087.1 C-terminal-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q9EQH5

UniProtKB/TrEMBL

A0A8I6AEI5, A6HX12

Conserved Domains (1) summary

cd05299
Location:34 → 352

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_039092156.2 → XP_038948084.1 C-terminal-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q9EQH5

UniProtKB/TrEMBL

A0A8I6AEI5, A6HX12

Conserved Domains (1) summary

cd05299
Location:34 → 352

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_063275196.1 → XP_063131266.1 C-terminal-binding protein 2 isoform X4
XM_039092165.2 → XP_038948093.1 C-terminal-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q9EQH5

UniProtKB/TrEMBL

A0A8I6AEI5, A6HX12

Conserved Domains (1) summary

cd05299
Location:34 → 352

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_063275191.1 → XP_063131261.1 C-terminal-binding protein 2 isoform X4
XM_063275154.1 → XP_063131224.1 C-terminal-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q9EQH5

UniProtKB/TrEMBL

A6HX12
XM_039092169.2 → XP_038948097.1 C-terminal-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q9EQH5

UniProtKB/TrEMBL

A0A8I6AEI5, A6HX12

Conserved Domains (1) summary

cd05299
Location:34 → 352

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_063275156.1 → XP_063131226.1 C-terminal-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q9EQH5

UniProtKB/TrEMBL

A6HX12
XM_039092139.2 → XP_038948067.1 C-terminal-binding protein 2 isoform X1

UniProtKB/TrEMBL

A0A8L2QC65

Related

ENSRNOP00000023574.3

Conserved Domains (1) summary

cd05299
Location:53 → 371

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_039092172.2 → XP_038948100.1 C-terminal-binding protein 2 isoform X3

UniProtKB/TrEMBL

A0A8I6AEI5, A0A8I6ALN3

Related

ENSRNOP00000093562.1

Conserved Domains (1) summary

cd05299
Location:21 → 339

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor