Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Itpr2provided by RGD
Full Name: inositol 1,4,5-trisphosphate receptor, type 2provided by RGD
Primary source: RGD:69649
See related: Ensembl:ENSRNOG00000001804 AllianceGenome:RGD:69649
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium ion binding activity; inositol 1,4,5 trisphosphate binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in cellular response to hypoxia and release of sequestered calcium ion into cytosol. Located in axon; endoplasmic reticulum; and myelin sheath. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 267.0), Kidney (RPKM 144.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 62

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (180759325..181165361, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (179028594..179434657, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (180423452..180800088, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inositol 1,4,5-trisphosphate receptor type 2 is associated with the bone-vessel axis in chronic kidney disease-mineral bone disorder.
Title: Inositol 1,4,5-trisphosphate receptor type 2 is associated with the bone-vessel axis in chronic kidney disease-mineral bone disorder.
The findings provide evidence that IP3R2 expression is transcriptionally regulated by cyclic AMP via CREB binding to CRE elements in its promoter.
Title: Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP.
ITPR2 and hypertrophy specific gene expression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin-NFATc signaling pathways.
Title: Calcineurin-NFATc regulates type 2 inositol 1,4,5-trisphosphate receptor (InsP3R2) expression during cardiac remodeling.
Inositol 1,4,5-trisphosphate and IP3 receptors act as inhibitors of autophagic processes in cardiomyocytes.
Title: Regulation of autophagy in cardiomyocytes by Ins(1,4,5)P(3) and IP(3)-receptors.
Pericanalicular calcium signaling mediated InsP3R2 plays an important role in maintaining bile salt secretion through posttranslational regulation of the bile salt export pump.
Title: Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes.
IP(3)R2 selectively associates with AC6, G alpha(s) also associates with the AC x IP(3)R signaling junction.
Title: Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase.
Elevated InsP(3)R2 expression was also detected in hearts from human patients with heart failure after ischemic dilated cardiomyopathy, as well as in aortic-banded hypertrophic mouse hearts.
Title: Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.
In native vascular myocytes, ACh-induced InsP3 production is transient and Ca2+ oscillations depend on a Ca2+ modulation of InsP3R2.
Title: Acetylcholine-induced Ca2+ oscillations are modulated by a Ca2+ regulation of InsP3R2 in rat portal vein myocytes.
apoptosis protection is conferred by enhanced spontaneous [Ca(2+)](i) signaling by Bcl-x(L) interaction with all isoforms of the InsP(3)R
Title: Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.
immobilization stress elevates mRNA of type 1 and 2 IP(3) receptors, mainly through the glucocorticoid responsive element
Title: Immobilization stress elevates IP(3) receptor mRNA in adult rat hearts in a glucocorticoid-dependent manner.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133051 (e-PCR)
- UniSTS:216334

d4mgh12 (e-PCR)
- UniSTS:121916

AU026991 (e-PCR)
- UniSTS:113736

Itpr2 (e-PCR)
- UniSTS:260517

AU046614 (e-PCR)
- UniSTS:111285

BE110085 (e-PCR)
- UniSTS:245180

BE100309 (e-PCR)
- UniSTS:249803

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ethanol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inositol 1,4,5-trisphosphate receptor type 2

Names: IP3 receptor; IP3R 2; inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor, type 2; inositol triphosphate receptor type 2; insP3R2; type 2 InsP3 receptor; type 2 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031046.4 → NP_112308.2 inositol 1,4,5-trisphosphate receptor type 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

Q6W3E4

Related

ENSRNOP00000077641.1, ENSRNOT00000103103.1

Conserved Domains (5) summary

pfam00520
Location:2290 → 2552

Ion_trans; Ion transport protein

pfam01365
Location:473 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 432

MIR; MIR domain

pfam08454
Location:1915 → 2022

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 228

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

180759325..181165361 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108425.1 → XP_038964353.1 inositol 1,4,5-trisphosphate receptor type 2 isoform X1

UniProtKB/TrEMBL

Q6W3E4

Conserved Domains (5) summary

pfam00520
Location:2340 → 2603

Ion_trans; Ion transport protein

pfam01365
Location:523 → 720

RYDR_ITPR; RIH domain

pfam02815
Location:282 → 482

MIR; MIR domain

pfam08454
Location:1965 → 2072

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:82 → 278

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_063286748.1 → XP_063142818.1 inositol 1,4,5-trisphosphate receptor type 2 isoform X1
XM_039108427.2 → XP_038964355.1 inositol 1,4,5-trisphosphate receptor type 2 isoform X2

UniProtKB/TrEMBL

Q6W3E4

Conserved Domains (5) summary

pfam00520
Location:2340 → 2602

Ion_trans; Ion transport protein

pfam01365
Location:523 → 720

RYDR_ITPR; RIH domain

pfam02815
Location:282 → 482

MIR; MIR domain

pfam08454
Location:1965 → 2072

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:82 → 278

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_039108429.2 → XP_038964357.1 inositol 1,4,5-trisphosphate receptor type 2 isoform X4

UniProtKB/TrEMBL

Q6W3E4

Conserved Domains (5) summary

pfam00520
Location:2228 → 2491

Ion_trans; Ion transport protein

pfam01365
Location:411 → 608

RYDR_ITPR; RIH domain

pfam02815
Location:170 → 370

MIR; MIR domain

pfam08454
Location:1853 → 1960

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:1 → 166

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_039108430.2 → XP_038964358.1 inositol 1,4,5-trisphosphate receptor type 2 isoform X4

UniProtKB/TrEMBL

Q6W3E4

Conserved Domains (5) summary

pfam00520
Location:2228 → 2491

Ion_trans; Ion transport protein

pfam01365
Location:411 → 608

RYDR_ITPR; RIH domain

pfam02815
Location:170 → 370

MIR; MIR domain

pfam08454
Location:1853 → 1960

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:1 → 166

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_039108428.2 → XP_038964356.1 inositol 1,4,5-trisphosphate receptor type 2 isoform X3

UniProtKB/TrEMBL

F1LNT1, Q6W3E4

Related

ENSRNOP00000043615.5

Conserved Domains (5) summary

pfam00520
Location:2290 → 2553

Ion_trans; Ion transport protein

pfam01365
Location:473 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 432

MIR; MIR domain

pfam08454
Location:1915 → 2022

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 228

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor