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Gyg1 glycogenin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81675, updated on 5-Mar-2024

Summary

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Official Symbol
Gyg1provided by RGD
Official Full Name
glycogenin 1provided by RGD
Primary source
RGD:621785
See related
Ensembl:ENSRNOG00000011146 AllianceGenome:RGD:621785
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gyg
Summary
Enables glucose binding activity and glycogenin glucosyltransferase activity. Involved in glycogen biosynthetic process. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease XV. Orthologous to human GYG1 (glycogenin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 1259.3), Heart (RPKM 551.6) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (104540927..104583038, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (102611888..102653916, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104916734..104958219, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485607 Neighboring gene helicase-like transcription factor Neighboring gene eukaryotic translation initiation factor 4 gamma 1, pseudogene 1 Neighboring gene carboxypeptidase A3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. No limiting role for glycogenin in determining maximal attainable glycogen levels in rat skeletal muscle. Hansen BF, et al. Am J Physiol Endocrinol Metab, 2000 Mar. PMID 10710493
  2. Molecular cloning and developmental expression of rat glycogenin in cardiac tissue. Pak BJ, et al. Mol Cell Biochem, 1999 Apr. PMID 10391131
  3. Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis. Bilyard MK, et al. Nature, 2018 Nov. PMID 30356213
  4. Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis. Chaikuad A, et al. Proc Natl Acad Sci U S A, 2011 Dec 27. PMID 22160680, Free PMC Article
  5. Glycogenin-1 deficiency and inactivated priming of glycogen synthesis. Moslemi AR, et al. N Engl J Med, 2010 Apr 1. PMID 20357282

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycogenin glucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycogenin glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycogenin glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glycogenin-1
Names
GN-1
GN1
NP_112305.1
XP_017446621.1
XP_038959150.1
XP_063138695.1
XP_063138696.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031043.2 → NP_112305.1  glycogenin-1

    See identical proteins and their annotated locations for NP_112305.1

    Status: PROVISIONAL

    Source sequence(s)
    AF021343
    UniProtKB/Swiss-Prot
    O08730
    UniProtKB/TrEMBL
    A6IHC8, F8WFR6
    Conserved Domains (2) summary
    cd02537
    Location:4 → 254
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    COG1442
    Location:9 → 221
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    104540927..104583038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591132.3 → XP_017446621.1  glycogenin-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXP1, F8WFR6
    Related
    ENSRNOP00000070350.2

  2. XM_063282626.1 → XP_063138696.1  glycogenin-1 isoform X3

  3. XM_063282625.1 → XP_063138695.1  glycogenin-1 isoform X2

  4. XM_039103222.2 → XP_038959150.1  glycogenin-1 isoform X4

    Conserved Domains (1) summary
    cl11394
    Location:1 → 96
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RNA

  1. XR_010063663.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08730.4 GenPept UniProtKB/Swiss-Prot:O08730

Gene LinkOut

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