Grm7 glutamate metabotropic receptor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grm7provided by RGD
Official Full Name: glutamate metabotropic receptor 7provided by RGD
Primary source: RGD:619857
See related: Ensembl:ENSRNOG00000005662 AllianceGenome:RGD:619857
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including PDZ domain binding activity; calmodulin binding activity; and glutamate binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; negative regulation of glutamate secretion; and negative regulation of neuron apoptotic process. Located in several cellular components, including dendritic shaft; rough endoplasmic reticulum; and synaptic membrane. Part of protein-containing complex. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 123.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q41

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (145286714..146169099)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (143730862..144613230)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (142452616..143368460)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathogenic GRM7 Mutations Associated with Neurodevelopmental Disorders Impair Axon Outgrowth and Presynaptic Terminal Development.
Title: Pathogenic GRM7 Mutations Associated with Neurodevelopmental Disorders Impair Axon Outgrowth and Presynaptic Terminal Development.
Analyses of NMR data suggested that the binding between Ca(2+)-saturated calmodulin (Ca(2+)/CaM) and mGluR7 occurs in some conformational equilibrium manner. The unique CaM-binding properties caused by Met872 may be related to mGluR7's function.
Title: Met872 is the key residue determining the novel binominal binding of metabotropic glutamate receptor 7 to calmodulin.
In control rats, mGluR7 stimulation facilitated pain responses and consistently modulated the rostral ventromedial medulla and dorsal reticular nucleus neuron activity. In neuropathic rats, AMN082 inhibited pain and consistently changed the rostral ventromedial medulla and dorsal reticular nucleus neural activity.
Title: Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats.
Findings demonstrated that the glutamic acid and mGluR7 in hippocampal CA3 region are involved in the modulation of nociceptive information transmission by regulating pain-evoked electric activities of pain-excited neurons and pain-inhibited neurons.
Title: Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for Modulating Pain-evoked Activities of Neurons in the Hippocampal CA3 Region of Rats.
Study indicates that functional activation of accumbal mGluR7 has antinociceptive effects that interfere with relief learning
Title: Metabotropic Glutamate Receptors 7 within the Nucleus Accumbens are Involved in Relief Learning in Rats.
Results suggested that beta-arr1 and 2 may differently modulate mGluR7 signaling in developmental sevoflurane neurotoxicity
Title: Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis.
Study demonstrated that mGluR7 can signal constitutively (in the absence of agonist) when expressed in neurons
Title: Constitutive activity of metabotropic glutamate receptor 7.
Activation of mGluR7 can produce antiparkinsonian-like effects in rats.
Title: Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats: a behavioral study with the selective agonist AMN082.
These results show that levels of mGluR7 in the Nucleus Accumbens regulate responsiveness to alcohol.
Title: Viral-mediated knockdown of mGluR7 in the nucleus accumbens mediates excessive alcohol drinking and increased ethanol-elicited conditioned place preference in rats.
Agonist-induced dephosphorylation of mGluR7 is regulated by PP1.
Title: Regulation of metabotropic glutamate receptor 7 (mGluR7) internalization and surface expression by Ser/Thr protein phosphatase 1.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH144597 (e-PCR)
- UniSTS:233842

AU028744 (e-PCR)
- UniSTS:112029

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate binding	IDA Inferred from Direct Assay more info	PubMed
enables glutamate binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables group III metabotropic glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables group III metabotropic glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables group III metabotropic glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables group III metabotropic glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables group III metabotropic glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables serine binding	IEA Inferred from Electronic Annotation more info
enables serine binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within associative learning	ISO Inferred from Sequence Orthology more info
involved_in axon development	IEA Inferred from Electronic Annotation more info
involved_in axon development	ISO Inferred from Sequence Orthology more info
involved_in axon development	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in behavioral fear response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within conditioned taste aversion	ISO Inferred from Sequence Orthology more info
involved_in glycosylation	IEA Inferred from Electronic Annotation more info
involved_in glycosylation	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal response to stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system process	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within short-term memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metabotropic glutamate receptor 7

Names: glutamate receptor, metabotropic 7; mGluR7; metabotropic glutamate receptor mGluR7; metabotropic glutamate receptor subtype 7b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031040.1 → NP_112302.1 metabotropic glutamate receptor 7 precursor

See identical proteins and their annotated locations for NP_112302.1

Status: PROVISIONAL

Source sequence(s)

D16817

UniProtKB/Swiss-Prot

P35400

UniProtKB/TrEMBL

A6IBL9, F1LZS5

Related

ENSRNOP00000053411.4, ENSRNOT00000056570.4

Conserved Domains (4) summary

cd06376
Location:47 → 511

PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor

pfam00003
Location:602 → 847

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:77 → 484

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:520 → 567

NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

145286714..146169099

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108423.2 → XP_038964351.1 metabotropic glutamate receptor 7 isoform X1

UniProtKB/TrEMBL

A6IBM0, F1LWV8

Related

ENSRNOP00000053829.5

Conserved Domains (3) summary

cd15451
Location:589 → 895

7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_039108424.2 → XP_038964352.1 metabotropic glutamate receptor 7 isoform X2

Conserved Domains (3) summary

cd15286
Location:589 → 827

7tmC_mGluR_group3; metabotropic glutamate receptors in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_039108422.2 → XP_038964350.1 metabotropic glutamate receptor 7 isoform X1

UniProtKB/TrEMBL

A6IBM0, F1LWV8

Conserved Domains (3) summary

cd15451
Location:589 → 895

7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_063286747.1 → XP_063142817.1 metabotropic glutamate receptor 7 isoform X3