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Dlat dihydrolipoamide S-acetyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 81654, updated on 11-Apr-2024

Summary

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Official Symbol
Dlatprovided by RGD
Official Full Name
dihydrolipoamide S-acetyltransferaseprovided by RGD
Primary source
RGD:619859
See related
Ensembl:ENSRNOG00000009994 AllianceGenome:RGD:619859
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables dihydrolipoyllysine-residue acetyltransferase activity. Involved in acetyl-CoA biosynthetic process from pyruvate and sleep. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1086.2), Muscle (RPKM 713.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q23
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (59875537..59900947, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (50979151..51004435, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55062549..55087832, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 8 homolog B Neighboring gene NKAP domain containing 1 Neighboring gene PIH1 domain containing 2 Neighboring gene DIX domain containing 1 Neighboring gene uncharacterized LOC120094337 Neighboring gene similar to human chromosome 11 open reading frame 52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Changes in brain gene expression after long-term sleep deprivation. Cirelli C, et al. J Neurochem, 2006 Sep. PMID 16923172
  2. Halothane metabolism: the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts. Christen U, et al. Biochemistry, 1993 Feb 16. PMID 8431428
  3. Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis. Gershwin ME, et al. J Immunol, 1987 May 15. PMID 3571977
  4. Molecular cloning of dihydrolipoamide acetyltransferase of the rat pyruvate dehydrogenase complex: sequence comparison and evolutionary relationship to other dihydrolipoamide acyltransferases. Matuda S, et al. Biochim Biophys Acta, 1992 May 7. PMID 1581353
  5. Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains. Yu X, et al. Structure, 2008 Jan. PMID 18184588, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables dihydrolipoyllysine-residue acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydrolipoyllysine-residue acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydrolipoyllysine-residue acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyllysine-residue acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables dihydrolipoyllysine-residue acetyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding TAS
Traceable Author Statement
more info
 PubMed 
contributes_to pyruvate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA biosynthetic process from pyruvate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
involved_in acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of pyruvate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pyruvate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
  
part_of pyruvate dehydrogenase complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Names
70 kDa mitochondrial autoantigen of primary biliary cirrhosis
E2
PBC
PDC-E2
PDCE2
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
pyruvate dehydrogenase complex component E2
NP_112287.1
XP_063122274.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031025.1 → NP_112287.1  dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

    See identical proteins and their annotated locations for NP_112287.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107440
    UniProtKB/Swiss-Prot
    P08461, Q3B7V7
    UniProtKB/TrEMBL
    A0A8I6B5J2, A6J4E7
    Related
    ENSRNOP00000032890.4, ENSRNOT00000032152.5
    Conserved Domains (4) summary
    cd06849
    Location:209 → 283
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    TIGR01349
    Location:211 → 632
    PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
    pfam00198
    Location:421 → 632
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    pfam02817
    Location:342 → 375
    E3_binding; e3 binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    59875537..59900947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266204.1 → XP_063122274.1  dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08461.3 GenPept UniProtKB/Swiss-Prot:P08461

Gene LinkOut

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