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Csnk2b casein kinase 2 beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 81650, updated on 22-Apr-2024

Summary

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Official Symbol
Csnk2bprovided by RGD
Official Full Name
casein kinase 2 betaprovided by RGD
Primary source
RGD:619978
See related
Ensembl:ENSRNOG00000000847 AllianceGenome:RGD:619978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ck2
Summary
Enables ribonucleoprotein complex binding activity. Involved in liver regeneration; postsynaptic modulation of chemical synaptic transmission; and response to testosterone. Located in several cellular components, including chromatin; cilium; and nuclear matrix. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Biomarker of myocardial infarction. Orthologous to human CSNK2B (casein kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 741.5), Heart (RPKM 387.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3704833..3709999)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3700363..3705331)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5108692..5113675, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein M Neighboring gene G4 protein Neighboring gene G patch domain and ankyrin repeats 1 Neighboring gene lymphocyte antigen 6 family member G5B Neighboring gene lymphocyte antigen 6 family member G5C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Quantitative proteome profiling of human myoma and myometrium tissue reveals kinase expression signatures with potential for therapeutic intervention. Lemeer S, et al. Proteomics, 2015 Jan. PMID 25327614
  2. Protein kinase CK2 associates to lipid rafts and its pharmacological inhibition enhances neurotransmitter release. Gil C, et al. FEBS Lett, 2011 Jan 21. PMID 21187092
  3. Protein kinase CK2 modulates synaptic plasticity by modification of synaptic NMDA receptors in the hippocampus. Kimura R, et al. J Physiol, 2008 Jul 1. PMID 18483072, Free PMC Article
  4. A role for CK2 upon interkinetic nuclear migration in the cell cycle of retinal progenitor cells. Carneiro AC, et al. Dev Neurobiol, 2008 Apr. PMID 18278803
  5. Protein kinase CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling: activation of Akt and inactivation of SGK1. Chao CC, et al. J Neurosci, 2007 Jun 6. PMID 17553997, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation.
    Title: Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation.
  2. CK2 Phosphorylation Is Required for Regulation of Syntaxin 1A Activity in Ca(2+)-Triggered Release in Neuroendocrine Cells.
    Title: CK2 Phosphorylation Is Required for Regulation of Syntaxin 1A Activity in Ca(2+)-Triggered Release in Neuroendocrine Cells.
  3. Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic beta-Cells of the Line INS-1.
    Title: Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1.
  4. NADPH oxidase activity is decreased by 5d, a novel analogue of 3-n-butylphthalide, through the positive regulation of CK2 after ischemia/reperfusion injury
    Title: 5d, a novel analogue of 3-n-butylphthalide, decreases NADPH oxidase activity through the positive regulation of CK2 after ischemia/reperfusion injury.
  5. alphaB-crystallin protects rat articular chondrocytes against CK2 inhibition-induced apoptosis.
    Title: Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis.
  6. ANXA1 promotes microglial activation and migration during oxygen-glucose deprivation/reperfusion via FPR, and CK2 target alpha-E-catenin phosphorylation is involved in this process.
    Title: Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion.
  7. Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2.
    Title: Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2.
  8. CK2-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance.
    Title: CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.
  9. our data show that CK2 induces the expression of the antiapoptotic gene Mcl-1 through activation of the SRF-mediated pathway in hippocampal CA1 neurons
    Title: Protein kinase CK2 enhances Mcl-1 gene expression through the serum response factor-mediated pathway in the rat hippocampus.
  10. Peroxynitrite activates Nrf2 via CK2 signaling, leading to the upregulation of HO-1 in primary chondrocytes.
    Title: Protein kinase CK2 mediates peroxynitrite-induced heme oxygenase-1 expression in articular chondrocytes.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adiponectin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adiponectin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial tube morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral life cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in symbiont-mediated disruption of host cell PML body IEA
Inferred from Electronic Annotation
more info
  
involved_in symbiont-mediated disruption of host cell PML body ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
is_active_in PML body ISO
Inferred from Sequence Orthology
more info
  
part_of PcG protein complex IEA
Inferred from Electronic Annotation
more info
  
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of PcG protein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IEA
Inferred from Electronic Annotation
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein kinase CK2 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
casein kinase II subunit beta
Names
CK II beta
Csnk2b-Ly6g5b
casein kinase 2, beta polypeptide
casein kinase 2, beta subunit
casein kinase II beta subunit
phosvitin
NP_001030315.1
NP_112283.1
XP_006256143.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035238.2 → NP_001030315.1  casein kinase II subunit beta

    See identical proteins and their annotated locations for NP_001030315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC078807, BX883045
    UniProtKB/Swiss-Prot
    P67874
    UniProtKB/TrEMBL
    N0E459, Q68G11
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  2. NM_031021.3 → NP_112283.1  casein kinase II subunit beta

    See identical proteins and their annotated locations for NP_112283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BX883045, EV778558
    UniProtKB/Swiss-Prot
    P67874
    UniProtKB/TrEMBL
    N0E459, Q68G11
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    3704833..3709999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256081.4 → XP_006256143.1  casein kinase II subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006256143.1

    UniProtKB/TrEMBL
    A0A8L2UP98, A6KTU1
    Related
    ENSRNOP00000068429.2
    Conserved Domains (1) summary
    smart01085
    Location:28 → 211
    CK_II_beta; Casein kinase II regulatory subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P67874.1 GenPept UniProtKB/Swiss-Prot:P67874

Gene LinkOut

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