Atf2 activating transcription factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81647, updated on 3-Apr-2024

Summary

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Official Symbol: Atf2provided by RGD
Official Full Name: activating transcription factor 2provided by RGD
Primary source: RGD:621862
See related: Ensembl:ENSRNOG00000001597 AllianceGenome:RGD:621862
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cAMP response element binding activity. Involved in several processes, including amelogenesis; positive regulation of neuron apoptotic process; and regulation of transcription by RNA polymerase II. Located in nucleus. Used to study hypertension and transient cerebral ischemia. Biomarker of glaucoma and transient cerebral ischemia. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 253.5), Thymus (RPKM 196.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Atf2 in Genome Data Viewer

Location:: 3q23

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (79125814..79202896, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (58718323..58795280, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (60721137..60795951, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that ATF2 participates in nerve injury-induced tactile allodynia and thermal hyperalgesia in rats.
Title: ATF2, but not ATF3, participates in the maintenance of nerve injury-induced tactile allodynia and thermal hyperalgesia.
The results suggest that the increase in uncoupling protein 1 (UCP1) content may occur via p38 MAPK and ATF2.
Title: A Low-Protein, High-Carbohydrate Diet Stimulates Thermogenesis in the Brown Adipose Tissue of Rats via ATF-2.
Following unilateral intracochlear stimulation, study quantified an increase of Fos expression with a simultaneous and locally corresponding decrease of pATF2 expression in major auditory brainstem regions of both hearing and deaf rats
Title: Counter-regulation of the AP-1 monomers pATF2 and Fos: Molecular readjustment of brainstem neurons in hearing and deaf adult rats after electrical intracochlear stimulation.
Caspase-3 is a target gene of c-Jun:ATF2 heterodimers during apoptosis induced by activity deprivation in cerebellar granule neurons.
Title: Caspase-3 is a target gene of c-Jun:ATF2 heterodimers during apoptosis induced by activity deprivation in cerebellar granule neurons.
phosphorylation of ATF-2 by c-Jun N-terminal kinase is associated with retinal ganglion cell death after axon damage.
Title: Early c-Jun N-terminal kinase-dependent phosphorylation of activating transcription factor-2 is associated with degeneration of retinal ganglion cells.
JNK/ATF2 pathway is involved in iodinated contrast media-induced apoptosis
Title: JNK/ATF2 pathway is involved in iodinated contrast media-induced apoptosis.
These results indicate that induced ATF-2/JunD association following polyamine depletion represses CDK4 transcription, thus contributing to the inhibition of intestinal epithelial cell growth.
Title: Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletion.
Results suggest that potassium deprivation-induced neuronal apoptosis is mediated by concurrent upregulation of c-Jun/ATF2 heterodimerization and downregulation of c-Fos expression.
Title: Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis.
Each member of AP-1 is expressed differently and that ATF-2 is more active than c-Jun and Fra-2 in physiological conditions in healthy rat jejunum.
Title: c-Jun, Fra-2, and ATF-2 immunoreactivity in the jejunal tissues of the healthy rat.
TGFbeta activates ATF2 phosphorylation and Csrp2 gene expression via a CRE promoter element.
Title: Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE107846 (e-PCR)
- UniSTS:247090

Atf2 (e-PCR), detects polymorphism
- UniSTS:515957

RH142313 (e-PCR)
- UniSTS:231560

AU028215 (e-PCR)
- UniSTS:112544

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables cAMP response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding	IDA Inferred from Direct Assay more info	PubMed
enables cAMP response element binding	IEA Inferred from Electronic Annotation more info
enables cAMP response element binding	ISO Inferred from Sequence Orthology more info
enables cAMP response element binding protein binding	IEA Inferred from Electronic Annotation more info
enables cAMP response element binding protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone H2B acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2B acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables leucine zipper domain binding	IEA Inferred from Electronic Annotation more info
enables leucine zipper domain binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in NK T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in NK T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in abducens nucleus development	IEA Inferred from Electronic Annotation more info
involved_in abducens nucleus development	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in amelogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process involved in development	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process involved in development	ISO Inferred from Sequence Orthology more info
involved_in brainstem development	IEA Inferred from Electronic Annotation more info
involved_in brainstem development	ISO Inferred from Sequence Orthology more info
involved_in cellular lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to anisomycin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to anisomycin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leucine starvation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect cellular response to leucine starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leucine starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in detection of cell density	IEA Inferred from Electronic Annotation more info
involved_in detection of cell density	ISO Inferred from Sequence Orthology more info
involved_in facial nucleus development	IEA Inferred from Electronic Annotation more info
involved_in facial nucleus development	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in growth plate cartilage chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in growth plate cartilage chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in hypoglossal nucleus development	IEA Inferred from Electronic Annotation more info
involved_in hypoglossal nucleus development	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in liver development	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic intra-S DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic intra-S DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neurofilament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in neurofilament cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta2 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription initiation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in vacuole organization	IEA Inferred from Electronic Annotation more info
involved_in vacuole organization	ISO Inferred from Sequence Orthology more info
involved_in white fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within white fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in white fat cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CCAAT-binding factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of H4 histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of H4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-2

Names: cAMP response element-binding protein CRE-BP1; cAMP-dependent transcription factor ATF-2

NP_112280.1

EC 2.3.1.48

XP_038961844.1

EC 2.3.1.48

XP_063140694.1

EC 2.3.1.48

XP_063140695.1

EC 2.3.1.48

XP_063140696.1

EC 2.3.1.48

XP_063140697.1

EC 2.3.1.48

XP_063140698.1

EC 2.3.1.48

XP_063140699.1

EC 2.3.1.48

XP_063140700.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031018.2 → NP_112280.1 cyclic AMP-dependent transcription factor ATF-2

See identical proteins and their annotated locations for NP_112280.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q00969, Q62870

UniProtKB/TrEMBL

A6HMA9, A6HMB2

Related

ENSRNOP00000002174.6, ENSRNOT00000002174.8

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:336 → 396

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

79125814..79202896 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284626.1 → XP_063140696.1 cyclic AMP-dependent transcription factor ATF-2 isoform X2

UniProtKB/TrEMBL

A0A8L2Q100, A6HMB1
XM_063284629.1 → XP_063140699.1 cyclic AMP-dependent transcription factor ATF-2 isoform X4
XM_039105916.2 → XP_038961844.1 cyclic AMP-dependent transcription factor ATF-2 isoform X3

Related

ENSRNOP00000046001.3

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:238 → 298

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_063284625.1 → XP_063140695.1 cyclic AMP-dependent transcription factor ATF-2 isoform X1

UniProtKB/Swiss-Prot

Q00969, Q62870

UniProtKB/TrEMBL

A6HMA9
XM_063284630.1 → XP_063140700.1 cyclic AMP-dependent transcription factor ATF-2 isoform X4
XM_063284628.1 → XP_063140698.1 cyclic AMP-dependent transcription factor ATF-2 isoform X3
XM_063284627.1 → XP_063140697.1 cyclic AMP-dependent transcription factor ATF-2 isoform X2

UniProtKB/TrEMBL

A0A8L2Q100, A6HMB1
XM_063284624.1 → XP_063140694.1 cyclic AMP-dependent transcription factor ATF-2 isoform X1

UniProtKB/Swiss-Prot

Q00969, Q62870

UniProtKB/TrEMBL

A6HMA9