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Adcy2 adenylate cyclase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81636, updated on 11-Apr-2024

Summary

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Official Symbol
Adcy2provided by RGD
Official Full Name
adenylate cyclase 2provided by RGD
Primary source
RGD:619965
See related
Ensembl:ENSRNOG00000032150 AllianceGenome:RGD:619965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AC2
Summary
Enables several functions, including G-protein beta/gamma-subunit complex binding activity; adenylate cyclase binding activity; and metal ion binding activity. Involved in several processes, including cAMP biosynthetic process; cAMP-mediated signaling; and cellular response to forskolin. Located in membrane raft and plasma membrane. Is integral component of plasma membrane. Part of protein-containing complex. Orthologous to human ADCY2 (adenylate cyclase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 209.9), Muscle (RPKM 172.5) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1p11
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (36204054..36650645)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (34375639..34822252)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (37043071..37698390)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit beta 1, pseudogene 1 Neighboring gene proteasome 20S subunit alpha 7, pseudogene 1 Neighboring gene transfer RNA proline (anticodon AGG) 24 Neighboring gene proteasome activator complex subunit 2-like Neighboring gene RNA, U6 small nuclear 783 Neighboring gene cilia and flagella associated protein 90 Neighboring gene FAST kinase domains 3 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source. Shen JX, et al. Biochem J, 2012 Nov 1. PMID 22906005, Free PMC Article
  2. Structure of the adenylyl cyclase catalytic core. Zhang G, et al. Nature, 1997 Mar 20. PMID 9069282
  3. A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. Chen J, et al. Science, 1995 May 26. PMID 7761832
  4. Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Feinstein PG, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1719547, Free PMC Article
  5. Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide. Townsend PD, et al. J Biol Chem, 2009 Jan 9. PMID 19008230, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AC2 is poised to yield both stimulatory and inhibitory outcomes of receptor activation.
    Title: Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source.
  2. AC2 interacts with RXFP1 through AKAP79, whereas the association with PDE4D3 and PKA depends upon beta-arrestin 2 binding to Ser704.
    Title: Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex.
  3. soluble adenylyl cyclase is responsive to both CO(2) and bicarbonate ion
    Title: Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide.
  4. Show that adenylyl cyclases 2 and 5 can form a functional heterodimeric complex in HEK293 cells and mouse myocardium.
    Title: Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables G-protein beta/gamma-subunit complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to forskolin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylate cyclase type 2
Names
ATP pyrophosphate-lyase 2
adenylate cyclase 2 (brain)
adenylate cyclase type II
adenylyl cyclase 2
NP_112269.2
XP_038947960.1
XP_038947965.1
XP_038947966.1
XP_038947972.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031007.3 → NP_112269.2  adenylate cyclase type 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P26769
    UniProtKB/TrEMBL
    A6JV23, F1LV12
    Related
    ENSRNOP00000038994.3, ENSRNOT00000047627.4
    Conserved Domains (3) summary
    pfam00211
    Location:882 → 1081
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:37 → 264
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:499 → 603
    DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    36204054..36650645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092044.2 → XP_038947972.1  adenylate cyclase type 2 isoform X4

    Conserved Domains (3) summary
    pfam00211
    Location:285 → 469
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:37 → 264
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:499 → 603
    DUF1053; Domain of Unknown Function (DUF1053)

  2. XM_039092038.2 → XP_038947966.1  adenylate cyclase type 2 isoform X3

    Conserved Domains (3) summary
    pfam00211
    Location:285 → 469
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:37 → 264
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:499 → 603
    DUF1053; Domain of Unknown Function (DUF1053)

  3. XM_039092032.2 → XP_038947960.1  adenylate cyclase type 2 isoform X1

    UniProtKB/Swiss-Prot
    P26769
    Conserved Domains (3) summary
    pfam00211
    Location:836 → 1035
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:37 → 264
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:499 → 603
    DUF1053; Domain of Unknown Function (DUF1053)

  4. XM_039092037.2 → XP_038947965.1  adenylate cyclase type 2 isoform X2

    UniProtKB/Swiss-Prot
    P26769
    Conserved Domains (3) summary
    pfam00211
    Location:816 → 1015
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:61 → 198
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:433 → 537
    DUF1053; Domain of Unknown Function (DUF1053)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26769.1 GenPept UniProtKB/Swiss-Prot:P26769

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