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tyms thymidylate synthetase [ Danio rerio (zebrafish) ]

Gene ID: 81540, updated on 4-Jan-2025

Summary

Official Symbol
tymsprovided by ZNC
Official Full Name
thymidylate synthetaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-59
See related
Ensembl:ENSDARG00000042894 AllianceGenome:ZFIN:ZDB-GENE-040426-59
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56465; zgc:77659
Summary
Enables thymidylate synthase activity. Acts upstream of or within dTMP biosynthetic process and retina development in camera-type eye. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including anterior neural tube; blood; nervous system; optic vesicle; and ventral mesoderm. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; digenic dyskeratosis congenita; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See tyms in Genome Data Viewer
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71535053..71541333)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71293912..71300192)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene alkaline ceramidase 2 Neighboring gene adenylate cyclase activating polypeptide 1a Neighboring gene methyltransferase 4, N6-adenosine

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
is_active_in cytosol  
is_active_in mitochondrion  

General protein information

Preferred Names
thymidylate synthase
NP_571835.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131760.2NP_571835.2  thymidylate synthase

    Status: VALIDATED

    Source sequence(s)
    EH577904, EH580067, FP016237
    UniProtKB/TrEMBL
    A0A8M1P903, Q6P045
    Related
    ENSDARP00000047068.6, ENSDART00000047069.7
    Conserved Domains (1) summary
    pfam00303
    Location:38318
    Thymidylat_synt; Thymidylate synthase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    71535053..71541333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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