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tyms thymidylate synthetase [ Danio rerio (zebrafish) ]

Gene ID: 81540, updated on 27-Mar-2024

Summary

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Official Symbol
tymsprovided by ZNC
Official Full Name
thymidylate synthetaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-59
See related
Ensembl:ENSDARG00000042894 AllianceGenome:ZFIN:ZDB-GENE-040426-59
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56465; zgc:77659
Summary
Enables thymidylate synthase activity. Acts upstream of or within dTMP biosynthetic process and retina development in camera-type eye. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including anterior neural tube; blood; nervous system; optic vesicle; and ventral mesoderm. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See tyms in Genome Data Viewer
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71535053..71541333)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71293912..71300192)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene alkaline ceramidase 2 Neighboring gene adenylate cyclase activating polypeptide 1a Neighboring gene methyltransferase 4, N6-adenosine

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos. Zhang Y, et al. PLoS One, 2010 May 12. PMID 20485548, Free PMC Article
  2. Sequence analysis and functional study of thymidylate synthase from zebrafish, Danio rerio. Du C, et al. J Biochem, 2006 May. PMID 16751599
  3. Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders. Frisk JH, et al. BMC Neurosci, 2022 Mar 27. PMID 35346037, Free PMC Article
  4. Dose- and time-dependent expression patterns of zebrafish orthologs of selected E2F target genes in response to serum starvation/replenishment. Sucularli C, et al. Mol Biol Rep, 2011 Aug. PMID 21116857
  5. Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Loponte S, et al. Sci Rep, 2016 Jul 26. PMID 27458029, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study revealed a structural requirement for the interaction of TS RNA with TS protein.
    Title: Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 5,10-methylenetetrahydrofolate-dependent methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables thymidylate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thymidylate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thymidylate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring one-carbon groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dTMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dTMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within dTMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dTTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thymidylate synthase
NP_571835.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131760.2 → NP_571835.2  thymidylate synthase

    Status: VALIDATED

    Source sequence(s)
    EH577904, EH580067, FP016237
    UniProtKB/TrEMBL
    A0A8M1P903, Q6P045
    Related
    ENSDARP00000047068.6, ENSDART00000047069.7
    Conserved Domains (1) summary
    pfam00303
    Location:38 → 318
    Thymidylat_synt; Thymidylate synthase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    71535053..71541333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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