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Pde1a phosphodiesterase 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 81529, updated on 3-Apr-2024

Summary

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Symbol
Pde1aprovided by RGD
Full Name
phosphodiesterase 1Aprovided by RGD
Primary source
RGD:68329
See related
Ensembl:ENSRNOG00000054212 AllianceGenome:RGD:68329
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
3-RACEclone8phosphodiesterase1A; 3'-RACEclone8phosphodiesterase1A
Summary
Enables calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process; regulation of smooth muscle cell apoptotic process; and regulation of smooth muscle cell proliferation. Located in cytoplasm; neuronal cell body; and nucleus. Orthologous to human PDE1A (phosphodiesterase 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 227.2), Brain (RPKM 205.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (85152053..85432289, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (64745140..65025178, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (66803247..67263658, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ITPR interacting domain containing 2 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1C Neighboring gene uncharacterized LOC134486399 Neighboring gene uncharacterized LOC103691836 Neighboring gene DnaJ heat shock protein family (Hsp40) member C10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries. Khammy MM, et al. Br J Pharmacol, 2017 Nov. PMID 28910498, Free PMC Article
  2. Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1. Giachini FR, et al. Hypertension, 2011 Mar. PMID 21282562, Free PMC Article
  3. Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells. Jeon KI, et al. FEBS J, 2010 Dec. PMID 21078118, Free PMC Article
  4. Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock. Cho CH, et al. Exp Mol Med, 2000 Sep 30. PMID 11048640
  5. Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Miller CL, et al. Circ Res, 2009 Nov 6. PMID 19797176, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pde1a is the dominant PDE1 isoform present in vascular smooth muscle cells, and relaxation mediated by PDE1A inhibition is predominantly driven by enhanced cGMP signalling.
    Title: PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.
  2. These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis
    Title: Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
  3. We conclude that PDE1 activation reduces cGMP bioavailability in arteries from Ang II, contributing to increased contractile responsiveness.
    Title: Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1.
  4. findings provide direct evidence for the first time that PP2A B56gamma is a critical mediator for PDE1A in the regulation of beta-catenin signaling in proliferating VSMCs
    Title: Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells.
  5. Expression mRNA levels of PDE1A (male > female) and PDE3B (male < female) were sex dependent in microvascular endothelial cells.
    Title: Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases.
  6. The PDE1A-PKCalpha signaling pathway is involved in the upregulation of alpha-smooth muscle actin by TGF-beta1 in adventitial fibroblasts.
    Title: The PDE1A-PKCalpha signaling pathway is involved in the upregulation of alpha-smooth muscle actin by TGF-beta1 in adventitial fibroblasts.
  7. a novel role for Ca(2+)/CaM-stimulated PDE1, particularly PDE1A, in regulating pathological cardiomyocyte hypertrophy via a cGMP/PKG-dependent mechanism, thereby demonstrating Ca(2+) and cGMP signaling cross-talk during cardiac hypertrophy.
    Title: Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.
  8. PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis.
    Title: Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of smooth muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Names
3'-RACE clone 8 phosphodiesterase 1A
3-RACE clone 8 phosphodiesterase 1A
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
phosphodiesterase 1A, calmodulin-dependent
NP_110498.1
XP_038961835.1
XP_038961836.1
XP_038961837.1
XP_038961838.1
XP_063140682.1
XP_063140683.1
XP_063140684.1
XP_063140686.1
XP_063140687.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030871.1 → NP_110498.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

    See identical proteins and their annotated locations for NP_110498.1

    Status: PROVISIONAL

    Source sequence(s)
    AF327838
    UniProtKB/TrEMBL
    A0A8I5Y792, Q9EPR9
    Related
    ENSRNOP00000087351.1, ENSRNOT00000099888.1
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    85152053..85432289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284612.1 → XP_063140682.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1

  2. XM_039105908.2 → XP_038961836.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y792, A0A8I6A416, A6HMM1
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  3. XM_039105909.2 → XP_038961837.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4

    UniProtKB/TrEMBL
    A0A0G2K2K1, A0A8I6A5M3
    Related
    ENSRNOP00000086595.1
    Conserved Domains (2) summary
    pfam00233
    Location:202 → 418
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:61 → 117
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  4. XM_039105910.2 → XP_038961838.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X7

    UniProtKB/TrEMBL
    A0A0G2JZX9, A0A8I6GJQ6
    Related
    ENSRNOP00000091537.1
    Conserved Domains (2) summary
    pfam00233
    Location:184 → 400
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:43 → 99
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  5. XM_063284613.1 → XP_063140683.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2

  6. XM_063284617.1 → XP_063140687.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5

    UniProtKB/TrEMBL
    A6HMM2

  7. XM_039105907.2 → XP_038961835.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y792, A6HMM2
    Related
    ENSRNOP00000077769.1
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  8. XM_063284614.1 → XP_063140684.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y879, A6HMM4

  9. XM_063284616.1 → XP_063140686.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X8

Nucleotide Protein Strain
Heading Accession and Version

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